SLO |
slowly renewing mesenchymal stem cells |
NT-7 |
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This is a mutagenized cell line derived from HT1080 cells (highly metastatic human fibrosarcoma) and characterized by a failure to degrade certain cytokine mRNAs (GM-CSF, TNF-alpha, IL2, IL3 and IL6) (Stoecklin et al, 2000, 2001). The underlying defect has been shown to be due to mutations in the BRF1 gene that encodes an RNA-binding protein that binds to AU-rich elements present in short-lived RNAs and is involved in mRNA decay (Stoecklin et al, 2002).
For related information of interest see also: Cell types Dictionary, Cell lines in Cytokine Research, Cell culture.
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