STAI4 |
stalkokines |
ubiquitin conjugating enzyme E2 E2 |
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[stalk cell]
These cells are specialized endothelial cells present in the stalk of vascular sprouts (Gerhardt et al, 2003) (see also subentry: endothelial cell sprouting in entry angiogenesis). Together with tip cells and phalanx cells these cells are important for sprouting angiogenesis (Ribatti and Crivellato, 2012). VEGF induces the membrane-bound Notch ligand delta-like-4 in the tip cells, which leads to the induction of the stalk cell phenotype in adjacent endothelial cells through the activation of Notch-1 (Kaipainen et al, 1995; Hellström et al, 2007; Suchting et al, 2007; Roca and Adams, 2007).
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