synovioblasts |
Synoviolin |
PSI |
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[synoviocyte]
These cells are fibroblasts and/or fibroblast-like cells that are found between the cartilaginous fibers in the synovial membrane of joints. The cells produce synovial fluid components and are responsible for absorption from the joint cavity, and for blood/synovial fluid exchanges. The expansion of fibroblast-like synoviocytes and the invasion of these cells into adjacent cartilage and bone, are considered a hallmark of rheumatoid arthritis. These cells proliferate, show anchorage-independent growth, and also secrete a variety of effector molecules that promote inflammation and joint destruction and, themselves are part of a complex network of autocrine and paracrine
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