|COPE Homepage||Bottom of page||Previous entry:
TIMP metallopeptidase inhibitor 4
cytoplasmic antiproteinase 3
please show your appreciation
by donating what you can afford.
abbr. TBM cells. tingible body macrophages are unique, large phagocytic cells that reside in germinal centers of secondary lymphoid tissues in close proximity to antigen-retaining follicular dendritic cells (Flemming, 1885). This cell type contains many phagocytized, apoptotic cells (referred to as tingible bodies) (Flemming, 1885) in various states of degradation (Swartzendruber and Congdon, 1963; Tabe et al, 1996). These cells have been referred to as type 1 phagocytes by Kotani et al (1977).
Tingible body macrophages also act as regulatory cells and endocytose immune-complex coated bodies derived from dendritic cells and thus may be involved in the downregulation of the germinal center reaction.
Tingible body macrophages strongly express MFG-E8, which binds to apoptotic cells by recognizing phosphatidylserine and enhances the engulfment of apoptotic cells. Knock-out mice lacking expression of MFG-E8 carry many unengulfed apoptotic cells in the germinal centers of the spleen, and develop a lupus-like autoimmune disease Hanayama et al (2004, 2006). Baumann et al (2002) have reported that apoptotic cells are not properly cleared by tingible body macrophages of the germinal centers in a sub-group of patients with systemic lupus erythematosus.
For related information of interest see also: Cell types.
Copyright © 2012 by H IBELGAUFTS. All rights reserved.
ENTRY LAST MODIFIED: June 2008
See REFERENCES for entry tingible body macrophages.
Click BACKLINKS to see which COPE entries contain the term tingible body macrophages .
|COPE Homepage||Top of Page|
|SUPPORT COPE | Santa Claus | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials|
|COPE is looking for long-term support from a company appreciating and committed to communication biology|
| Access to COPE is free only for academic institutions and non-profit organizations. |
OTHER USERS: must contact COPE and pay a site licence fee.