tissue plasminogen activator

abbr. tPA (a term with multiple meanings); also: tissue-type plasminogen activator. The human gene has been cloned by Browne et al (1985). The approved gene symbol is PLAT [plasminogen activator, tissue].

Tissue plasminogen activator is known mainly for its activity as a serine protease (EC3.4.21.68) expressed by vascular endothelial cells. The enzyme plays a key role in fibrinolysis by activating the proenzyme plasminogen to plasmin (for a review of its pharmacological application in the treatment of ischemic stroke see: Frey, 2005).

Apart from its well-known pharmacological activities as a thrombolytic agent, tissue plasminogen activator can be seen as an extracellular ... ... ... ...
 
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Entry last modified: July 2005