tribbles |
tribbles 2 |
EC2.7.7.49 |
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approved gene symbol TRIB1 [tribbles pseudokinase 1; tribbles homolog 1], abbr. also TRB1. Tribbles 1 is one of three mammalian homologs of Drosophila melanogaster tribbles (gene: CG5408). Tribbles 1 has been identified independently as SKIP1 (Wu et al, 2003), and C8FW (an acronym for clone 8 Françoise Wilkin; Wilkin et al, 1997).
Kiss-Toth et al (2004) have identified tribbles 1 as a gene that represses the basal activity of the IL8 promoter.
Satoh et al (2013) have reported that tribbles 1 is critical for the differentiation of certain types of tissue macrophages
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