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vIRS

[viral inhibitor of RIP-mediated signaling] This protein, named by Brune et al (2001), is encoded by open reading frame M45 of MCMV [murine cytomegalovirus] (MCMV M45; murine cytomegalovirus M45). Upton et al (2008) have referred to the protein as vIRA [viral inhibitor of RIP1 activation].

Mutant viruses lacking expression of vIRS rapidly induce apoptosis in cultured endothelial cells and macrophages thereby precluding viral spread (Brune et al, 2001). vIRS interacts with RIP1 [receptor interacting protein-1] and blocks necroptosis induced by TNFR1 and ... ... ... ... ... Subscribe to continue reading! ... ...

 

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