vav-2 |
vav-3.1 |
DC-SIGN-1 |
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[vav guanine nucleotide exchange factor 3; guanine nucleotide exchange factor vav3] vav-3 shares a high degree of sequence similarity with vav-1 and vav-2 (Trenkle et al, 2000). An N-terminally truncated splice variant of vav-3, termed vav-3.1, has been identified by Trenkle et al (2000). The full-length protein is sometimes being referred to as vav-3-alpha. Vav-3 and the related genes vav-1, and vav-2 share a conserved domain structure: an amino-terminal calponin homology domain, followed by an acidic region, a catalytic Dbl homology domain involved in the guanine nucleotide exchange reaction, a pleckstrin homology domain, a
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