Search results for IFN-gamma

1767 matches found in 855 out of 54954 COPE entries.

... activation of NK-cells has been shown to induce cytokine (IFN-gamma) and matrix metalloproteinase production (MMP-2) and NK- ...

... as evident from increased cytolytic function, induction of IFN-gamma production, and NK-cell invasiveness (Garni-Wagner et al, ...

... is inducible on these cells by IL2, IL12 or IL15 but not by IFN-gamma. For additional information on CD antigens see also: CD ...

... with human IL2, IL3, IL4, IL5, IL6, or rat or human IFN-gamma, all of which do not have an effect on rat astrocytes. ...

... . Stimulation of 2D6 cells with IL12 induces production of IFN-gamma and IL10. The 2D6 clone also responds vigorously to IL2, ...

... . 2D6 lines maintained with IL12 produce large amounts of IFN-gamma when restimulated with IL12 after starvation of either ...

... . 2D6 lines maintained with IL2 produce small amounts of IFN-gamma when restimulated with IL2 after starvation of either ...

... et al, 1998). In the presence of IL12 2D6 cells produce IFN-gamma in response to IGIF. The cells also express the receptor ...

... with IL12 or addition of IGIF does not lead to IFN-gamma production. Simultaneous stimulation of these 2D6 cells ...

... with both cytokines dramatically increases IFN-gamma production. Overnight exposure of cells maintained in the ...

... by Däubener et al (1994) as a sensitive bioassay for IFN-gamma. The amount of kynurenine produced appears to be directly ...

... proportional to the amount of IFN-gamma used to activate cells. The detection limit for IFN-gamma ...

... 2D9 cells. Knüpfer et al (2000) have reported that IFN-gamma markedly decreases the viability and proliferation of ...

... Colony formation assay) has been shown to be unaffected by IFN-gamma, which partially or completely inhibits the replication of ...

... results in the efficient induction of tissue factor. IFN-gamma upregulates the efficiency of calcium ion mobilization in ...

... 7TD1 cells driven by IL6. Murine IFN-alpha, IFN-beta, and IFN-gamma strongly inhibit proliferation of 7TD1 cells in a dose- ...

... beta1 and extrinsic (porcine) beta-2 subunits. They produce IFN-gamma in response to human and porcine IL12, which appears to be ...

... to cell death by apoptosis. Treatment of 32D cells with IFN-gamma (but not IFN-alpha or IFN-beta) inhibits cell death by ...

... of syngeneic accessory cells. The addition of IL1-alpha or IFN-gamma, or incubation of T-cells with IL2, IL4, IL1-alpha, IFN- ...

... human diploid fibroblasts. 160 SF is not identical with IFN-gamma, IFN-alpha, TNF, or TGF-beta. Copyright © 1997-2021. ...

... including IL2, IL3, G-CSF, GM-CSF, and M-CSF. IFN-alpha or IFN-gamma upregulate the expression of Class 1 antigens and ICAM-1 ( ...

... A20 protects islets from apoptosis induced by IL1-beta and IFN-gamma (Grey et al, 1999). Expression of A20, mediated by binding ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... protein 1-8U) (Marroqui L et al, 2015) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... Actimmune: a recombinant form of IFN-gamma. The drug has been approved for the treatment of Chronic ...

... in the stimulation of cytokines, most markedly with IFN-gamma. Homologs of CDT have been found in a variety of bacterial ...

... monocytes is enhanced by GM-CSF and to a lesser degree by IFN-gamma. Its synthesis in bone marrow stromal cells is induced by ...

... synergistically (Benigni et al, 1996). IL1 and also IFN-gamma reduce some of the effects of IL6. Some of the effects of ...

... keratinocytes or peripheral blood T-cells treated with IFN-gamma, and inhibits the binding of IFN-gamma-treated human thymic ...

... information about interferons, and IFN-alpha, IFN-beta, IFN-gamma), TNF-alpha, TNF-beta and IL4. ADCC defects in combination ...

... of the Th1 cytokines and proimmflamatory cytokines IFN-gamma, TNF-alpha, and IL6. Adenosine deaminase acts as a ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... Ge D and You Z, 2008) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... Sun et al, 2009) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... 2010) • PUMA-G (protein upregulated in macrophages by IFN-gamma, HM74, HM74B, GPR109B, G-protein-coupled receptor-109B; ...

... , 1999). Thrombin, VIP (vasoactive intestinal peptide) and IFN-gamma also inhibit Adrenomedullin production, while angiotensin-2 ...

... and endothelin-1 secretion but to a lesser extent. IFN-gamma inhibits adrenomedullin secretion from endothelial cells, ...

... phorbol-13-acetate, retinoic acid, lipopolysaccharides, and IFN-gamma. IFN-gamma completely suppresses Adrenomedullin production ...

... adrenomedullin into the conditioned medium in response to IFN-gamma, TNF-alpha, and IL1-beta (Takahashi et al, 2000). ...

... secretion by fibroblasts, whereas TGF-beta-1 and IFN-gamma suppress it (Isumi et al, 1998). Adrenomedullin inhibits ...

... pathogen Listeria monocytogenes. Production of IFN-gamma and TNF-alpha by NK-cells and macrophages is significantly ...

... T-cell repertoire in vivo. These high avidity AFP-specific IFN-gamma producing T-cells can recognize tumor cells and can be ...

... IL2, IL3, IL4, IL5, IL6, IL7, GM-CSF, TNF-alpha, TNF-beta, IFN-gamma, and TGF-beta. AGF shows some activities similar to IL1; ...

... . The expression of AIF-1 transcripts is upregulated by IFN-gamma in rat macrophages (Autieri et al, 1998). AIF-1 is ...

... smooth muscle cells synthesis of AIF-1 is induced by IFN-gamma, IL1-beta, and conditioned medium of T-cells. ...

... . Production of IL18 and NK-cell dependent production of IFN-gamma, events critical in the early control of virus replication ...

... AK155 gene maps to chromosome 12q15 in the vicinity of the IFN-gamma gene and the gene encoding IL22 (IL-TIF) (Dumoutier et al, ...

... receptors, 2B4. Alloferon also increases the production of IFN-gamma and TNF-alpha and granule exocytosis from NK-cells. Lastly ...

... inhibits NO synthesis induced by a combination of LPS and IFN-gamma. NO synthesis inhibition is associated with decreased ...

... kinase activity and to be up-regulated by EGF, TNF-alpha, IFN-gamma, and IL1-beta. Kloth et al (2008) have reported that ...

... . They express high levels of IL1R1 and IL23R and secrete IFN-gamma, IL17, and GM-CSF in response to canonically restricted ...

... role in that in vivo administration of ALR in rats reduces IFN-gamma production by liver-resident NK-cells (Polimeno et al, 2000 ...

... and several putative regulatory sequences for IL4 and IFN-gamma dependent transcriptional pathways, including STAT6 and ...

... IL4, IL13, and IL10. Expression of AMAC-1 is inhibited by IFN-gamma. Glucocorticoids exert a slightly positive synergistic ...

... multiple ligands of TLR receptors (TLR2, TLR4, TLR9) and IFN-gamma. In databanks the protein is being referred to also as ...

... differentiation whereas the anti-fibrotic cytokines IFN-gamma and IL12 inhibit fibrocyte differentiation. The fibrocyte- ...

... , Heart derived inhibitor of vascular cell proliferation, IFN-gamma, IL1, LDGF (Leiomyoma-derived growth factor), MCP-1 (see ...

... activity for vascular endothelial cells), HBNF, HGF, HUAF, IFN-gamma, IL1, K-FGF, LIF, MD-ECI, MECIF, NPY, Oncostatin M, PD-ECGF ...

... , Endostatin, PF4 (platelet factor-4), IFN-alpha and IFN-gamma, PRP (proliferin-related protein), Thrombospondin isolated ...

... bull; IFI16-beta • Ifi202 • IFN-alpha • IFN-gamma • IFN-gamma-inducible protein gamma-2 • IFP53 ...

... cytokine receptor constructs (IL1 receptor, IL5 receptor, IFN-gamma receptor) are being considered for the treatment of a wide ...

... induced interferon: This interferon is identical with IFN-gamma. See also: IFN for general information about interferons. ...

... and iNOS expression in response to stimulation with IFN-gamma is not inhibited. The effect is due to direct binding of ...

... IL8 and CCL2 but has no effect on CXCL10, CXCL9, IL12-p70, IFN-gamma, IL10. The peptide also augments PGE2 biosynthesis in the ...

... CXCL1 (KC), CXCL5 (LIX), CXCL9 (mig), CXCL10 (IP10), G-CSF, IFN-gamma, IL1-alpha, IL1-beta, IL13, IL17, IL6, M-CSF, TNF-alpha) ...

... ; Monajemi et al, 2002). APOL1 expression is inducible by IFN-gamma and TNF-alpha in human umbilical vein endothelial cells, ...

... both apoptosis and autophagy in smooth muscle cells. IFN-gamma treatment strongly induces expression of APOL6 in smooth ...

... of the pro-inflammatory cytokines TNF-alpha, IL6, IL12, and IFN-gamma are upregulated to a significantly greater extent in knock- ...

... bowel disease (Kontoyiannis et al, 1999). In the case of IFN-gamma, the removal of the ARE sequence leads to serologic and ...

... proteins including the Epo receptor and the JAK2 kinase. IFN-gamma and TNF-alpha induce expression of FAS antigen and ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... et al, 2003; Farina et al, 2005; Rubio et al, 2010) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Lau and ...

... Simone et al, 1998; Villalba M et al, 2012) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ) (Nichols et al, 2009) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... Y et al, 2014) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... (2012) have reported that the direct antiviral activity of IFN-gamma against murine norovirus infection requires the ATG12 / ...

... ATG5 / ATG16L complex, but not induction of autophagy. IFN-gamma, via this complex, inhibits the formation of the membranous ...

... cytokines and growth factors, including GM-CSF, IFN-alpha, IFN-gamma, IL1-alpha, IL6, IL8, IL10, LIF, NGF, S100, TNF-alpha. ...

... shown that treatment of fibroblast-like synoviocytes with IFN-gamma reduces the expression of Autotaxin (Santos et al, 1996). ...

... also show a significantly diminished capacity to express IFN-gamma. Role in cancer O'Bryan et al (1991) have identifed ...

... -bound B7RP-1 co-stimulate T-cell proliferation in vitro. IFN-gamma, IL10 and other cytokines, are induced by B7H co- ...

... to allogenic T-cell proliferation and production of IL2 and IFN-gamma. Expression on dendritic cells and monocytes is ...

... and CD8(+) T-cells and selectively increases expression of IFN-gamma (Chapoval et al, 2001; Sun et al, 2002). Hashiguchi et al ( ...

... B7-H3 preferentially up-regulates the proliferation and IFN-gamma production of CD8(+) T-cells. Transduction of TLT-2 into T- ...

... cells results in enhanced IL2 and IFN-gamma production via interactions with B7-H3. Blockade of the ...

... of a spectrum of inflammatory cytokines and chemokines (IFN-gamma, TNF-alpha, IL17, CCL2, CCL11, CXCL9, CXCL10). Enhanced T- ...

... particular in naIve and activated T-cells, unstimulated and IFN-gamma stimulated bone marrow derived dendritic cells, as well as ...

... of B7-H6 on target cells with NKp30 on NK-cells leads to IFN-gamma production and target cell killing (Brandt et al, 2009). ...

... CD4(+) T-cell proliferation and cytokine production (IL2, IFN-gamma, TNF-alpha and IL10) via an AKT-dependent signaling cascade ...

... and is induced on B-cells after stimulation with LPS and IFN-gamma. These authors have reported that B7-H7 inhibits rather ...

... reduces cytokine production by T-cells, including IFN-gamma, TNF-alpha, IL5, IL10, IL13, IL17A, and IL22. Janakiram et ...

... similarity to the extracellular binding domain of cellular IFN-gamma receptors and binds IFN-gamma. Expression of the B8R gene ...

... reduction in immunogenicity (Verardi et al, 2001). The IFN-gamma soluble receptors encoded by vaccinia virus, cowpox virus, ...

... the biological activity of human, bovine, rat, chicken IFN-gamma but not mouse IFN-gamma (Alcami and Smith, 1995; Puehler et ...

... of B9 cells driven by IL6. Murine IFN-alpha, IFN-beta, and IFN-gamma strongly inhibit proliferation of B9 cells in a dose- ...

... 2004) have reported that exogenous IFN-alpha, IFN-beta, and IFN-gamma can rescue human macrophages from cell death induced by ...

... to apoptosis induced by TNF-alpha-, anti-FAS antibodies and IFN-gamma. The transgenic mice have been found to be resistant to ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... IFN, F-IFN, IFF) receptors (Chen et al, 2003) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... MacGlashan D Jr, 2012) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... Z et al, 2018) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) (Wang Z ...

... and differentiation of B-cells are IL1, IL2, IL4, IL5, IL6, IFN-gamma, TNF-alpha and TNF-beta. The term BCDF is still used, ...

... : BSF-1; B-cell stimulating factor-1); IL5 (see: BCGF-2), IFN-gamma, or TGF. B-BCGF acts on activated B-cells, but not on ...

... are IL2, IL5 (see: BCGF-2, B-cell growth factor-2), and IFN-gamma. The aberrant expression of a B-cell maturation factor is ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... al, 2004; Pogue et al, 2004; Bauvois et al, 1999) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Airoldi ...

... et al, 2000; Yoshimoto et al, 1998) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ; Yuan J et al, 2010) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... H et al, 2018) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) (Zhang H ...

... of B-cells are CD23, IL1, IL2, IL4, IL5, IL6, IL10, IL12, IFN-gamma, TNF-alpha and TNF-beta. In combination with IL5 and other ...

... cells is abrogated by TGF-beta and to a lesser extent by IFN-gamma. BCL1 cells also constitutively secrete IL10 into the ...

... -55-specific Th9 cells decreases IL9 production and induces IFN-gamma, causing an exacerbation of the clinical disease. Liao W ...

... 145 amino acids that specifically inhibits the synthesis of IFN-gamma. BCRF-1 closely resembles IL10 and, therefore, is called ...

... mediate Th1 cell response, including T-cell proliferation, IFN-gamma production, and CD4(+) CCR5(+) Th1 development. In the ...

... by osteoblasts and its production is enhanced by IFN-gamma (Canalis et al, 1980, 1986, 1987; Canalis and Centrella, ...

... is not necessary for their development. Be1 cells produce IFN-gamma and also express IFN-gamma receptors, which provides an ...

... genetic background of B-cells influences the magnitude of IFN-gamma produced by Be1 cells. Expression of the T-box ...

... transcription factor T-bet and of IFN-gamma receptors is necessary for the development of Be1 cells. ...

... signals and/or cytokines to the developing Be1 cells. IFN-gamma produced by Th1 effector cells is required for the ...

... For a cell type that may correspond to Be1 cells see also: IFN-gamma-producing innate B-cells. de Goër de Herve MG et al ( ...

... that a sequential and coordinated action of IFN-alpha, IFN-gamma and IL12, via the action of STAT4 and T-bet is necessary ...

... for their development. IFN-alpha primes naive B-cells for IFN-gamma production and increases IFN-gamma gene responsiveness to ...

... IL12. IFN-gamma continues this polarization by re-inducing T-bet and up- ...

... regulating IL12R-beta-2 expression. IFN-alpha and IFN-gamma therefore pave the way for the action of IL12. For related ...

... a concomitant down-regulation of T-bet, IL12R-beta-2, and IFN-gamma. Up-regulation of IL4 in the Be2 cells is dependent on both ...

... -expressing effector cells that down-regulate expression of IFN-gamma and do not, unlike Be1 cells, terminally differentiate into ...

... factor production. They make higher levels of both IL2 and IFN-gamma in response to mitogen stimulation (Tarleton et al, 1992). ...

... -7 can also modulate cytokine secretion (IL4, IL13, IFN-gamma) in peripheral blood mononuclear cells (Fiedorowicz et al, ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... ; Coomans de Brachène A et al, 2018) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... been reported to stimulate splenocyte proliferation and IFN-gamma production in vitro. Hydrolysis of these peptides with L. ...

... stimulation, up-regulate IL10 production, and down-regulate IFN-gamma and IL4 secretion (Prioult et al, 2004). For the ...

... same inhibitory action on bFGF activities is shown also by IFN-gamma which is itself induced by different forms of FGF. In ...

... , 1992; Hangoc G et al, 1989). This activity is mediated by IFN-gamma and the effect is, in turn, reversible by Epo (Means RT and ...

... itself does not display IL2 or IL1 activity and IFN-alpha, IFN-gamma, TNF, IL4, IL5, IL6 do not display BGEF-2 activity. BGEF-2 ...

... in many tissues. Downregulation of BGP-1a expression by IFN-gamma is associated with resistance to infection by mouse ...

... is seen in peripheral blood mononuclear cells activated by IFN-gamma (but not by LPS), in monocytes activated by adherence to ...

... plastic or IFN-gamma, and in subsets of dendritic cells. Enforced expression of ...

... 12-myristate 13-acetate. Cytokines such as IL4, IL6, and IFN-gamma do not upregulate expression. For additional information ...

... bleb-matured dendritic cells induce the production of IL2, IFN-gamma, and IL17, suggesting a Th1 cell / Th17 cell response ...

... cells derived from monocytes require stimulation with IFN-gamma for surface expression of the protein. The release of ...

... soluble BLyS is regulated by IFN-gamma and to a lesser extent IL10. Gorelik et al (2004) have ...

... antibody production, induces both of Th1 cell (IL2 and IFN-gamma) and Th2 cell (IL4 and IL10) cytokines, increases ...

... that Brp39 has an inhibitory role in the expression of IFN-gamma but up-regulates pro-inflammatory mediators, CCL2, CXCL2 ...

... immune effector functions with increased production of IFN-gamma and decreased CCL2, CXCL2 and MMP-9 expression. In vivo ...

... concentrations. In vitro bryostatins induce the release of IFN-gamma, Interleukins, and hematopoietins (Hematopoietic growth ...

... virus, enhancing antibody production, stimulating IL4 and IFN-gamma, and inducing T-cell and lymphocyte proliferation. For ...

... types following stimulation with type 1 interferons and IFN-gamma. Blasius et al (2006) have shown also that BST-2 resides ...

... class 2 antigens are induced in BT-20 cells by IFN-alpha, IFN-gamma, and IL1 (IL1-alpha). BT-20 cells are used to detect ...

... activities, which induce cell death by apoptosis. Human IFN-gamma appears to be the only other cytokine showing greater than ...

... cell activation marker CD25, and inhibits the production of IFN-gamma, IL2, IL4, and IL10. Sedy et al (2005) have identified ...

... lymphoma cells. This is mediated in part by IL12 and IFN-gamma. The authors have suggested that immune activation may ...

... also secrete C1INH, often in response to cytokines such as IFN-gamma IFN-alpha, M-CSF, IL6, and TNF-alpha (Prada et al, 1998). ...

... the activation of T-cells. C1q is required for optimal IFN-gamma production by T-cells. Liu et al (2008) have reported that ...

... by virtue of its ability to inhibits the production of IFN-gamma by murine splenocytes in response to treatment with IL12 ( ...

... vaccinia virus infection and promotes virulence by reducing IFN-gamma production and NK-cell and T-cell activity. Falivene et al ...

... by 1 Alpha,25-dihydroxyvitamine D3 (but not by TNF-alpha or IFN-gamma), and in human THP-1 leukemia cells (monocytes) by phorbol ...

... . CARD4 stimulation does not induce TNF-alpha, IL12, and IFN-gamma, suggesting that its primary role is to induce the ...

... susceptible to this infection and show a strongly reduced IFN-gamma production at the innate phase of infection, which can be ...

... and innate lymphoid cell responses. Reduced levels of IL6, IFN-gamma, and Th17 cytokines are found in colon tissues and ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... 2, IFN-alphaR2, IFNABR) (Lau SL et al, 2012) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... MF and de Bold, 2009) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... et al, 2006) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) (Murray ...

... expression in response to bacterial lipopolysaccharides and IFN-gamma requires NF-kappa-B and the signal transducer STAT1 ( ...

... -11 deficient mice are deficient in the production of IFN-gamma. IL1-beta responses are normal with intravenous ...

... activation through bacterial lipopolysaccharides and IFN-gamma. Nitric oxide (NO) is the major autocrine mediator in this ...

... resistant to cell death by apoptosis induced by LPS and IFN-gamma. Inhibition of NO synthesis and Caspase-11 completely ...

... blocks LPS and IFN-gamma induced cytotoxicity. (Lee et al, 2001; Suk et al, 2002). ...

... 1 caspases include the zymogen form of IL1-beta and IGIF [IFN-gamma inducing factor], which are substrates that play a role in ...

... with inflammatory myopathies and on myoblasts stimulated by IFN-gamma. This process is independent of the degradation of the MHC ...

... of reactive oxygen species, which is also involved in IFN-gamma production that upregulates Cathepsin S expression. Burden ...

... by augmenting expression of the T-cell effector molecules IFN-gamma, TNF-alpha, granzyme B, and perforin. CCDC134 facilitates ...

... differentiation and secretion of its key effector molecules IFN-gamma and IL17A via regulation of JAK-STAT signaling. Role ...

... the small intestinal epithelial cell line, mIC(c12), with IFN-gamma, IL4 or TNF-alpha. The chemokine has been shown to possess ...

... cytotoxic activity against TSA parent cells and to secrete IFN-gamma and IL2 when restimulated by TSA parent cells. Copyright & ...

... have been shown to secrete IL6 (but not IL1, TNF-alpha or IFN-gamma) into the conditioned medium in response to treatment with ...

... 1995. Treatment of CCL-185 cells with low concentrations of IFN-gamma significantly increases the plating efficiency in soft agar ...

... trafficking of antigen presenting cells capable of inducing IFN-gamma production by T-cells and produce markedly less IFN-gamma ...

... be regulated by cytokines such as IL1-alpha, TNF-alpha, and IFN-gamma. Lack or low expression of CCX-CKR correlates with a poor ...

... (+) and CD8(-) produce factors such as IL4, IL5, IL10 and IFN-gamma (see also: T-helper cells). CD4 functions as an effector ...

... synovium, and cartilage, and its expression is enhanced by IFN-gamma. Oliveira et al (2012) have reported that CD6, which is ...

... result in degranulation but induces secretion of cytokines (IFN-gamma, TNF-alpha) and chemokines (CXCL10, CXCL1). CD6 has been ...

... death of microglia and astrocytes induced by LPS or LPS / IFN-gamma, and suppresses glial neurotoxicity in a coculture of glia ...

... In monocytes they are induced by IL3, IL4, and GM-CSF, and IFN-gamma. In IL4-stimulated B-cells the synthesis of sCD23 is ...

... inhibited by IFN-gamma. IFN-gamma also promotes the release of sCD23 in epidermal Langerhans ...

... cells. The synthesis of sCD23 mediated by IFN-gamma or IL4 can be inhibited by IFN-alpha. The membrane form of ...

... activation site and that IFN-alpha, IFN-beta, and IFN-gamma can induce the expression of CD26 in malignant B-cells ( ...

... that most Gamma-Delta T-cells express CD27 and secrete IFN-gamma, whereas IL17 production is restricted to CD27(-) Gamma- ...

... synthesis and secretion of IL2, IL13, TNF-alpha, GM-CSF, IFN-gamma and TNF-beta. CD28 is a receptor for costimulatory ...

... in the serum and a nearly complete impairment of IFN-gamma secretion in response to TSST-1 injection. CD28 ...

... by IP-10, a factor the expression of which is induced by IFN-gamma. The proliferation of human CD34(+) cells is stimulated ...

... ) cytokines (IL1ra, IL1-beta, IL6, TNF-alpha TNF-beta, IFN-gamma, IFN-beta) are defective in monocyte-derived macrophages ...

... monocytes is observed after treatment with GM-CSF, IL3, or IFN-gamma. CD40 has been proposed to play a role in the development ...

... as evident from increased cytolytic function, induction of IFN-gamma production, and NK-cell invasiveness (Garni-Wagner et al, ...

... receptor ICAM-1 [intercellular adhesion molecule 1] IFN-gamma regulated human melanoma-associated antigen Ly47 MALA-2 ( ...

... vascular endothelial cells is upregulated by TNF-alpha and IFN-gamma and these cytokines also reduce complement 3 (C3) ...

... 29 cells IL1-beta is a weak inducer and IL6, IL8, IL10, and IFN-gamma have no effect (Andoh et al, 1996, 1997; Nasu et al, 1998 ...

... -H596 cells) is increased by IL1-alpha and TNF-alpha, and IFN-gamma (Varsano et al, 1998, 2000). In the human bronchial ...

... cell line BEAS-2B CD55 expression is upregulated by IFN-gamma, TNF-alpha (Varsano et al, 1998, 2000). In human hepatoma ...

... release of soluble CD58 is highly responsive to IL1-beta, IFN-gamma, and TNF-alpha. This modulation is cell-specific, ...

... particularly with regard to IFN-gamma, which up-regulates soluble CD58 release by A431 cells but ...

... TNF-alpha, IL1-beta and low (but not high) concentrations IFN-gamma (Bjorge et al, 1995). In human hepatoma cells the ...

... on mononuclear phagocytes. Its expression is induced by IFN-gamma. The receptor can be released by cells and circulates in ...

... R1 expression in these animals is regulated in vivo by IFN-gamma and IL10 (Heijnen et al, 1995). For additional information ...

... functioning as a homophilic adhesion molecule and enhancing IFN-gamma secretion in human lymphocytes. For additional ...

... cytokines that support T-cell expansion and function (IL2, IFN-gamma, and IL13) (Saverino et al, 2002). Young et al (2008) have ...

... proliferation and synthesis of pro-inflammatory cytokines IFN-gamma and IL17A. CD85l: This is another designation for ILT9 ...

... induces the production of the Th1 cytokines TNF-alpha and IFN-gamma but not that of the Th2 cytokines IL4 or IFN-gamma ( ...

... CD119: [CD119(+), CD119(-)] New designation for IFN-gamma receptor-1, the type 1 receptor of IFN-gamma (IFN-gamma ...

... receptor-1, IFN-gamma-R1, interferon-gamma receptor 1; approved gene symbol: ...

... Substantial proportions of CD137(+) T-cells do not produce IFN-gamma, suggesting that CD137 detects a broader repertoire of ...

... in a unique profile of cytokine secretion (TNF-alpha, IFN-gamma, IL6) by cytotoxic CD56(dim) CD16(+) NK-cells (Barakonyi et ...

... on target cells inhibits NK-cell mediated cytotoxicity and IFN-gamma secretion. Binding of LLT1 to CD161 in the presence of a ...

... TCR signal enhances IFN-gamma production by T-cells. Kleinschek et al (2009) have ...

... from patients with Crohn's disease readily produce IL17 and IFN-gamma upon stimulation with IL23, whereas, in healthy subjects, ...

... pro-inflammatory mediators IL4, IL13, TNF-alpha, and LPS / IFN-gamma. The protein acts as an endocytic receptor but does not ...

... . Expression on monocytes is minimal but can be induced by IFN-gamma. For additional information on CD antigens see also: CD ...

... antibodies directed against CD3. The antibody also inhibits IFN-gamma, IL2, IL4 and IL10 production in these activated T-cells. ...

... induced transmembrane protein 1] • Ifitm like • IFN-gamma receptor-1 • IFN-gamma regulated human melanoma- ...

... inhibits cell death by apoptosis caused in HeLa cells by IFN-gamma. The authors have suggested that CDIR may inhibit apoptosis ...

... of HeLa cells to these death-inducing ligands induced by IFN-gamma. CDIR abrogates sensitization to FAS, and enhances the ...

... sensitization to TRAIL. CDIR mediates IFN-gamma-induced apoptosis, at least in part, by reducing the level ...

... is also severely impaired. Cytokines such as TNF and IFN-gamma, known to be involved in cell activation of macrophages, ...

... to IL2, IL4, IL7 • 2D9 (glioblastoma) (detection of IFN-gamma) • 2E8 (B-cells) (detection of human IL7, murine IL7 ...

... bull; HL-60 (promyelocytic leukemia cells) (detection of IFN-gamma, LIF, Activin A, human G-CSF) • HM1-SV40 (human ...

... of IL4) • RAW264.7 (macrophages) (detection of murine IFN-gamma) • RBL-2H3 (rat mast cell / basophil cell line) & ...

... ; WISH (amnion epithelial cells) (detection of IFN-alpha, IFN-gamma) • XG-1 (myeloma cells) (detection of IL6) & ...

... Gamma-cells • Gamma-Delta T-cells • gamma-IMCs [IFN-gamma-producing immature myeloid cells] • Gamma-Kenyon ...

... cells] • IEL [Intraepithelial lymphocytes] • IFN-gamma-producing B-cells • IFN-gamma-producing immature ...

... myeloid cells • IFN-gamma-producing innate B-cells • IFN-producing cells &bull ...

... ; IFNgamma-MdC [IFN-gamma-stimulated monocyte-derived cells] • IG cells &bull ...

... cells • Tc10 cells • Tc17 cells • Tc17/IFN-gamma cells • Tc2 cells • Tc22 cells • Tc9 ...

... by IL4. G-CSF-stimulated growth of CFU-G is inhibited by IFN-gamma, and this effect is counteracted by IL4. IL4 inhibits ...

... treated with IL2 produce and release TNF-alpha and IFN-gamma, which suppress CFU-G. Colony formation from CFU-G is ...

... have reported that MIP-1-alpha, MIP-2, TGF-beta, TNF-alpha, IFN-gamma and Tbeta(4), inhibit the growth of CFU-GM when murine WEHI ...

... of which is inducible by bacterial lipopolysaccharides, IFN-gamma, and TNF-alpha has been identified as a specific ...

... , CD38 and HLA-DR. The cells respond to IL3, IL4, IL34, IFN-gamma, SCF, and colony stimulating factors (see: CSF). CFU-M is ...

... to colony stimulating factors is stimulated further by IFN-gamma and this effect is reversed by IL4. Colony formation from ...

... accumulation of mRNA coding for TNF-alpha, TNF-beta, and IFN-gamma. CGRP also appears to act on murine F9 teratocarcinoma ...

... of CD56(+) cells. Antibodies directed against IL2, IFN-gamma, but not those directed against IL1-beta, TNF-alpha, IL8, ...

... bet for specification. These cells coproduce high levels of IFN-gamma and TNF-alpha and protect against infections with the ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... IFN, IFF) (Harada et al, 2007; Mohanty et al, 2013) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Yang CY ...

... ; Huang YH et al, 2007; Barnes et al, 2009) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... ) (Palmer et al, 2004; Liu X et al, 2015) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... Tanigawa S et al, 2011) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... X et al, 2015) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... Tachikawa et al, 1997; Douglas et al, 2009) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) (Samal et ...

... human peripheral blood mononuclear cells in the presence of IFN-gamma, anti-CD3 monoclonal antibody, IL1, and IL2. The timing of ...

... IFN-gamma treatment is critical and optimal results are obtained when ...

... IFN-gamma is added before IL2 treatment. CIK cells depend on ...

... A et al, 2005, 2009; Tomita et al, 2009) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... , IFN-kappa, IFN-tau and IFN-omega), the type 2 interferon (IFN-gamma), and the type 3 interferons (IFN-lambda) (IL28A, IL28B, ...

... , for example, the genes encoding IL2, IL3, IL4 IL5, IFN-gamma, G-CSF and GM-CSF. CLE serves as a binding site for ...

... , unlike their wild-type counterparts that expressed IFN-gamma and especially granzyme B. The almost complete absence of ...

... derived from human kidney fibroblasts. TNF-alpha, IL6, and IFN-gamma upregulate expression of CLF-1 mRNA in primary cell ...

... ) which is not identical with IL1, IL2, IL4, IFN-alpha or IFN-gamma also appears to be identical with IL12. Copyright © ...

... -inflammatory cytokines TNF-alpha, IL6, and IL8 and also of IFN-gamma. The antioxidant N-acetyl-L-cysteine counteracts these ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... shock protein 70-1) (Kojima et al, 2003) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ; Stevens et al, 1997) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... of TNF-alpha, and suppresses IL10 production mediated by IFN-gamma, suggesting that deficiency of C5 leads to an anti- ...

... IL1-beta in a process depending on caspase-1. This promotes IFN-gamma production and differentiation of T-helper 1 cells in an ...

... suppresses the production of Th1 cytokines, such as IL2, IFN-gamma, and TNF-alpha, in murine spleen cells. The administration ...

... complement factor H in various cell types is upregulated by IFN-gamma (Schlaf et al, 2002; Friese et al, 1999; Luo and Vic, 1999 ...

... H mRNA. Expression in these cells is not inducible by IFN-gamma but expression is inducible in U937 cells by TNF-alpha. ...

... -I results in the significantly increased production of IFN-gamma, TGF-beta-1, and TNF-alpha but not IL10 and IL4. The ...

... are not seen in knock-out mice lacking expression of IFN-gamma, showing that the induction of FOXP3 is mediated through ...

... the ability of Copolymer-I to produce IFN-gamma. Chen et al (2009) have reported that the treatment ...

... IL10 by Th2 cells and inhibits the antitumor Th1 cytokines (IFN-gamma and IL2) (Chen et al, 2011; Markosyan et al, 2011). ...

... after cell activation with LPS and IL1 but not TNF-alpha or IFN-gamma (Yen et al, 1997). Copyright © 1997-2021. All rights ...

... and members of the interferon family, IFN-alpha, IFN-beta, IFN-gamma, as well as type 3 interferons (IFN-lambda-1 = IL29, IFN- ...

... of murine RAW264.7 cells (derived from macrophages) with IFN-gamma or the conditioned medium of a mitogen-stimulated spleen ...

... acids. Its synthesis is induced by IFN-alpha, IFN-beta, IFN-gamma, and bacterial lipopolysaccharides. It is identical with, ...

... CRH inhibits proliferation of keratinocytes and enhances IFN-gamma stimulated expression of adhesion molecules. An inhibitory ...

... the growth inhibitory effects of IFN-alpha, IFN-beta, and IFN-gamma on primary hematopoietic progenitor cells (BFU-E, CFU-GM) ( ...

... , 2002; Szalai et al, 2002) and represses the synthesis of IFN-gamma (Szalai et al, 2002). Pentameric CRP has been shown to ...

... . This interaction promotes cytotoxicity of NK-cells and IFN-gamma secretion of CD8(+) T-cells in vitro as well as rejection ...

... defects. T-cells from these mice produce lower amounts if IFN-gamma, IL22, and IL17, but show increased T-cell receptor- ...

... other things, inhibits the release of IL2, IL3, IL4, IL5, IFN-gamma, GM-CSF and TNF-alpha. CsA does not act directly but exerts ...

... to IL1, IL3, IL6, IL7, IL10, IL12, GM-CSF, G-CSF, M-CSF or IFN-gamma. and are used in sensitive and specific bioassays for IL4. ...

... 1) (Memili et al, 2007) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... blood mononuclear cells stimulated with dsRNA and IFN-gamma and fibroblasts stimulated with dsRNA, IFN-gamma, and LPS ...

... RAW264.7 macrophages expression of CXCL11 is induced by IFN-gamma or bacterial polysaccharides. IFN-alpha or IFN-beta are ...

... weak inducers of gene expression. The effect of IFN-gamma is enhanced markedly by costimulation with LPS or IL1-beta ...

... strongly attenuates expression of CXCL11 induced by IFN-gamma in RAW264.7 cells and by endotoxemia in lung and small ...

... some degree by stimulation of these cells with IL1-beta and IFN-gamma. Upregulation is seen also after bacterial exposure. ...

... some degree by stimulation of these cells with IL1-beta and IFN-gamma. Upregulation is seen also after bacterial exposure. ...

... on human NK-cells is upregulated by TGF-beta-1, but not by IFN-gamma, MIP-3-beta, MDC, TARC or I-309 (Inngjerdingen et al, 2001 ...

... on human NK-cells is upregulated by TGF-beta-1, but not by IFN-gamma, MIP-3-beta, MDC, TARC or I-309 (Inngjerdingen et al, 2001 ...

... by adherence and moderately by exposure to TNF-alpha and IFN-gamma. Shimizu et al (2005) have reported expression of CyCAP in ...

... . In response to endotoxin, these mice overproduce IL12 and IFN-gamma systemically and TNF-alpha locally. These pro-inflammatory ...

... , and its levels are modulated by TSH, insulin, IGF-1, and IFN-gamma. Increased expression of the protein is observed after ...

... is expressed in both dermal fibroblasts and keratinocytes. IFN-gamma increases CyCAP expression in cultured rat fibroblasts. ...

... -alpha through its binding with CCR5 and the production of IFN-gamma and IL6 in a CCR5-independent manner. Treatment of ...

... (-) NK-cells and monocytes. CySF-L2 induces the release of IFN-gamma from CD3(+) T-cells and CD56(+) CD3(-) NK-cells and of TNF- ...

... alpha and prostaglandin E2 from monocytes. Induction of IFN-gamma release appears to be the crucial step during CySF-L2 ...

... of NK-cell activity is completely blocked when anti-IFN-gamma antibodies are present during treatment of human peripheral ...

... ) have reported that Cystatin SA induces the production of IFN-gamma (but not IL4) in human CD4(+) T-cells, suggesting an ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... IFN-gamma (IFNG, Gamma-Interferon, gIFN) • serum concentrations ...

... IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4) & ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) • ...

... pg/mL IL33 concentration strongly correlated with levels of IFN-gamma, TNF-alpha, and IL17-alpha. (Voloshyna et al, 2015) &bull ...

... , IL4, IL6, IL7, JE, GM-CSF, G-CSF, TNF-alpha, IFN-alpha, IFN-gamma. It has been shown also that vaccination with cells ...

... expressing IFN-gamma, IL2, IL4, IL6, IL7 or TNF-alpha increases systemic ...

... . The assay has been established for the detection of IFN-gamma and is also suitable for the early detection of IL1 and IL4 ...

... . Under optimal conditions IFN-gamma concentrations are higher (3-20-fold) than in conventional ...

... cultures, IFN-gamma production is detectable as early as 2 hours and IFN-gamma ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) • ...

... IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... D7L (Esteban et al, 2004) • human factor induces IFN-gamma production in bovine T-cells (Shoda et al, 1999) • ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) • ...

... are the transient lymphopenias induced by IFN-alpha, IFN-gamma, IL2 and TNF-alpha, transient monocytopenias induced by IFN ...

... receptor family includes receptors for IFN-alpha, IFN-beta, IFN-gamma, IL10, TF (tissue factor), and IL-TIF. One member has been ...

... of murine RAW264.7 cells (derived from macrophages) with IFN-gamma or the conditioned medium of a mitogen-stimulated spleen ...

... by Th2 T-helper cells. Type 1 cytokines include IL2, IFN-gamma, IL12 and TNF-beta, while Type 2 cytokines include IL4, IL5 ...

... beta, IL2, IL4, IL5, IL6, IL8, IL10, IL12, IL15, IFN-alpha, IFN-gamma, and TNF-alpha share 93 to 99 % homology at the nucleic ...

... . IL2, IL4, IL7, IL9, IL13, IL3, IL5, GM-CSF, M-CSF, SCF, IFN-gamma form short chain 4 helix bundles. So-called beta-trefoil ...

... HepG2 cells, depending upon concentration. The interferon IFN-gamma can stimulate the proliferation of B-cells prestimulated ...

... antagonist (see: IL1ra). Several cytokines, including TNF, IFN-gamma, IL2 and IL4, are inhibited by soluble receptors (see also ...

... activation by antigens, capture of a secreted cytokine (IFN-gamma), by an artificial cytokine-specific cell surface affinity ...

... is distinct from IL1, IL2, IL3, IL4, IL5, IL6, IL7, IL9, IFN-gamma, GM-CSF, TGF-beta, TNF, Lymphotoxin. CSIF can inhibit the ...

... production of IL2, IL3, TNF-beta, IFN-gamma, and GM-CSF by Th1 T-helper cells responding to antigen and ...

... is not identical with IL1, IL2, IL3, IL4, IL5, IL6 or IFN-gamma. Copyright © 1997-2021. All rights reserved by Dr H ...

... production of several pro-inflammatory cytokines, including IFN-gamma and IL17A, and there is a marked increase in the lamina ...

... in response to bacterial endotoxins, human or murine IFN-gamma, TNF-alpha, TNF-beta, or GM-CSF. D10 cells also ...

... , antigens, and immobilized anti-CD3 antibody is blocked by IFN-gamma, which does not, however, block IL4 production. An ...

... for their ability to survive in the continuous presence of IFN-gamma (Levy-Strumpf and Kimchi, 1998). DAP-1 is a small proline- ...

... as a mediator of cell death by apoptosis induced by IFN-gamma (Deiss et al, 1995). The human gene maps to chromosome 5p12 ...

... for their ability to survive in the continuous presence of IFN-gamma (Kissil et al, 1995; Kissil and Kimchi, 1998). In some ...

... as a mediator of cell death by apoptosis induced by IFN-gamma. The mRNA for DAP-3 is expressed ubiquitously in human ...

... a marked reduction in the number of cells resistant to IFN-gamma. DAP-3 has been identified as a component of the ...

... for their ability to survive in the continuous presence of IFN-gamma (Kissil and Kimchi, 1998). DAP-5 (Levy-Strumpf et al, 1997 ...

... as a mediator of cell death by apoptosis induced by IFN-gamma (Levy-Strumpf et al, 1997). For other entries pertaining ...

... kinase 4] mediate cell death by apoptosis elicited by IFN-gamma in microglial cells. IFN-gamma upregulates the expression ...

... Depletion of Daxx or STK4 attenuates cell death induced by IFN-gamma. The extent of IFN-gamma-induced death of microglia in the ...

... (Zavros et al, 2004), whereas it is inhibited directly by IFN-gamma (Zavros et al, 2004). D cells have been shown to ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... A et al, 2010; Kumar et al, 2011) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... of downstream effector cytokines (TNF-alpha, IL1-beta, IFN-gamma, and IL12-p70) implicated in shock pathogenesis, and ...

... RNA helicase, has been shown to be produced in response to IFN-gamma and virus infection in primary human hepatocytes. It is ...

... cytokines, including TNF-alpha, IL6, IL17, IL1-beta, IFN-gamma and MCP-1 (Zhang et al, 2018). Copyright © 1997-2021 ...

... (I:C) and by pro-inflammatory stimuli e.g. TNF-alpha and IFN-gamma. Its expression seems to be regulated by activation of the ...

... . In vitro, HNPs significantly increase the levels of IFN-gamma, IL6, and IL10, but not IL4 or IL5, from both Peyer’s ...

... cells, which can be enhanced upon stimulation with IFN-gamma, LPS, or CD40L. The conditioned medium of these cells has ...

... containing TNF-alpha, IL1-beta, poly-I:C, IFN-alpha, and IFN-gamma (Mailliard et al, 2004). Gustafsson et al (2008) have ...

... , and secrete IL12 upon CD40 ligation in the presence of IFN-gamma. The cells possess full T-cell stimulatory capacity and can ...

... antigens to naive antigen-specific T-cells, and produce IFN-gamma in response to IL4 plus either IL2 or CpG (see also: ...

... killer dendritic cells). CpG, but not IL2, induces IFN-gamma secretion via the autocrine effects of IL12. In vivo, CpG ...

... induces murine natural killer dendritic cells to produce IFN-gamma and inhibit tumor growth. In vivo overexpression of flt-3 ...

... their potent lytic capacity, secrete an abundant amount of IFN-gamma, inhibit melanoma lung metastases in a tumor prevention ...

... , characterized as CD11c(int) B220(+) NK1.1(+) produces IFN-gamma and efficiently reduce the tumor size of transplanted ...

... in mice. The rapid and strong expression of IFN-gamma by NK dendritic cells after alpha-galactosylceramide ...

... dendritic cells, elicit Th2 cell responses, produce IFN-gamma but no IL12 (Siegal et al, 1999; Cella et al, 1999). Hata ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... , IFNABR) (Gauzzi et al, 2002; Zhang et al, 2009) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Hochrein ...

... ; Lapteva N et al, 2001; Remondo et al, 2009) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... Yamaguchi et al, 2007) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... HJ et al, 2009) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... induced by IL7, but inhibits proliferation induced by IL2. IFN-gamma produced by dendritic epidermal T-cells inhibits ...

... ligands. Cross-linking of NKG2D on these cells induces IFN-gamma production. For related information of interest see also: ...

... of IL10 and IL17, inhibit IL4 production, and do not alter IFN-gamma production. For related information of interest see also: ...

... that of wild-type mice. Production of IL2 and IL4, but not IFN-gamma, in transgenic T-cells is augmented after engagement of the ...

... death triggered by various stimuli, such as TNF-alpha and IFN-gamma (Inbal et al, 2000, 2002). Shani G et al (2001) have ...

... ) • IFN-alpha(9-28) • IFN-beta(150-187) • IFN-gamma-inducible protein gamma-2 • IFN-tau(156-195) • ...

... of the gene in ovine fibroblasts treated with IFN-alpha or IFN-gamma protects the unrelated Semliki Forest virus from the ...

... ) are markedly reduced and these cells produce less IL4 and IFN-gamma. Omata et al (2001) have reported that the expression of ...

... footpads as compared with wild-type mice. Antigen-specific IFN-gamma production of lymph node cells from these mice shows little ...

... 2005) • PUMA-G (protein upregulated in macrophages by IFN-gamma, HM74, HM74B, GPR109B, G-protein-coupled receptor-109B; ...

... endothelial cell apoptosis in response to TNF-alpha / /IFN-gamma, etoposide, and anoikis, but has no effect on proliferation ...

... (RLK [resting lymphocyte kinase]). This complex regulates IFN-gamma gene transcription in Th1 cells. Schulz et al (2014) have ...

... , but also produce pro-inflammatory cytokines, such as IL6, IFN-gamma and GM-CSF in contrast to other subsets, usually termed ...

... that binds to the same receptor, induce the synthesis of IFN-gamma. In several in vitro systems murine and human TGF-alpha ...

... /mL. NOB-1 cells are not responsive to TNF-alpha, TNF-beta, IFN-gamma, and bacterial lipopolysaccharides. Both cell lines are ...

... is biased toward a type 1 response (production of IL12, IFN-gamma, and IgG2a). Thus, elafin has significant potential in ...

... (2005) have shown that VGVAPG favors a Th1 cytokine (IL2, IFN-gamma) cell responses in T-cells. Péterszegi G et al ( ...

... inflammatory agents such as bacterial lipopolysaccharides, IFN-gamma, and TNF-alpha. Reape et al (1999) have shown that ELC is ...

... in aortic smooth muscle cells stimulated with TNF-alpha and IFN-gamma. Muller et al (2001) have described the development of ...

... expression of ENA-78 is induced by IL1 and downregulated by IFN-gamma. Synovial fluid and blood of patients with rheumatoid ...

... in response to TNF-alpha or IL1-beta, but not with IL4 or IFN-gamma. Analysis of ESM-1 expression in normal human tissues by ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... 2, IFN-alphaR2, IFNABR) (Davidson et al, 1994) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Jones et ...

... al, 1997) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ; Kitaya et al, 2000) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... et al, 2005) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... and cell activation increases production and secretion of IFN-gamma and VEGF-A, with the latter supporting vascular sprouting ...

... the expression of CD36 receptor and modulats TNF-alpha IFN-gamma release from lipid-laden macrophages and thus has anti- ...

... -1 T-cell proliferation is impaired, and less IL12 and IFN-gamma are produced in the culture supernatant. Role in ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... -IFN, F-IFN, IFF) receptors (da Silva et al, 2002) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Li et al ...

... , 2000, 2004) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ) (Yang RB et al, 2003) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) (Zhang W ...

... et al, 2011) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... to the toxic activity of TNF-alpha. It has been shown that IFN-gamma is a central mediator in the development of LPS ...

... resistant to LPS due to an impairment in the production of IFN-gamma. A recently developed monoclonal anti-LPS antibody has ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... beta) (Malago et al, 2003; Hershko et al, 2003) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Parlesak ...

... et al, 2004) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... WL and Lee YK, 2008) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... activate eosinophils that have been primed with IL5 or IFN-gamma to release mitochondrial DNA in a reactive oxygen species- ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... 2, IFN-alphaR2, IFNABR) (Aldebert et al, 1996) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Hatano et ...

... ; Spencer et al, 2009; Kobayashi et al, 2010) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... PF et al, 2008) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... by IL1-alpha or TNF-alpha within 6 hrs and modulated by IFN-gamma. Induction by IL1-alpha is transient while long-term ...

... upregulated by IL13 or IL4 but not by TNF-alpha, IL1-beta, IFN-gamma or a combination of TNF-alpha plus IFN-gamma. Eotaxin-3 ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... Chen R et al, 2017) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) (Mishra ...

... T-cell proliferation, with concomitant augmentation of IFN-gamma but not IL2 or IL4 secretion. The activity of cytotoxic T- ...

... Lymphoid Cell also express NK-cell markers and secrete IFN-gamma upon stimulation. For related information of interest see ...

... immune-responsive genes like IL10, IL1-beta, TNF-alpha, and IFN-gamma. Protection against Vibrio vulnificus and enhanced ...

... marker for antigen-presenting cells) is seen in response to IFN-gamma (Lu et al, 1994). Singhrao et al (1999) have reported that ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... -alpha. This synthesis is not affected by IL6, TGF-beta and IFN-gamma. PROTEIN CHARACTERISTICS Epo is a relatively heat- and pH ...

... specificity, and its expression is strongly upregulated by IFN-gamma. Reducing the expression of ERAAP prevents the trimming of ...

... antibody responses. CD71(+) cells ablation induces IL17 and IFN-gamma in the lungs and spleen upon re-infection or vaccination. ...

... (+) regulatory T-cells, regulate cytokine responses (IL6, IFN-gamma, and IL4, IL10) mounted by myeloid cells in the presence of ...

... ), and syndecan; GM-CSF binds to extracellular matrix HSPG; IFN-gamma binds to extracellular matrix HSPG; IL3 binds to ...

... -CSF, IL3 (multi-CSF), stem cell inhibitor (see: SCI), LIF, IFN-gamma, PF4 (platelet factor-4) and amphiregulin, can be bound to ...

... by antibodies directed against TNF, TGF-beta, IFN-alpha and IFN-gamma. See also: F-1. Copyright © 1997-2021. All rights ...

... expression of FAM26F, whereas the number of cells producing IFN-gamma is decreased markedly in the early phase. Lack of FAM26F in ...

... cells and macrophages, leads to a robust decrease in IFN-gamma production. FAM26F effectively suppresses lung metastasis ...

... melanoma cells, which is controlled by NK1.1(+) cells and IFN-gamma. Copyright © 1997-2021. All rights reserved by Dr H ...

... cells. In some cells FAT10 expression is induced by IFN-gamma or TNF-alpha. FAT10 has been shown to associate with MAD2, ...

... Raasi et al, 2001). Lukasiak et al (2008) have shown that IFN-gamma and TNF-alpha synergistically upregulate FAT10 expression ...

... in both cancer tissues correlates with expression of the IFN-gamma and TNF-alpha dependent proteasome subunit LMP2, strongly ...

... extent the cells also respond to IL4, IGF-1 (see: IGF), and IFN-gamma, with IL4 and IFN-gamma mainly prolonging survival for ...

... the same treatment (Hirayama et al, 1993). TNF-alpha and IFN-gamma increase the amount of cellular mRNA for H-Ferritin, but ...

... . H-Ferritin markedly increases production of IL10 and IFN-gamma by anti-CD3-stimulated lymphocytes (Gray et al, 2001). H- ...

... -derived monocytic cells is induced by M-CSF, GM-CSF, and IFN-gamma. fgr has been implicated in regulation of the behavior of ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... , 1991; Li et al, 2002; Huleihel et al, 1990) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ; Qiu Z et al, 2009) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... Ferretti M et al, 2005) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... a Th2 cytokine profile with decreased production of IL2 and IFN-gamma and increased production of IL4 and IL10. Exposure of ...

... ) with TGF-beta-1 increases synthesis of Fibronectin and IFN-gamma inhibits it (Ramadori et al, 1992). Varga et al (1990) have ...

... fibroblasts induced by TGF-beta is augmented further by IFN-gamma. By conducting studies employing antisense Fibronectin RNA ...

... , 1987), and TGF-beta, bacterial lipopolysaccharides, and IFN-gamma (Pendino et al, 1994). M-CSF renders mononuclear phagocytes ...

... integrin-beta-1 (Molossi et al, 1995). TNF-alpha, IL1, and IFN-gamma act as inhibitors of migration of microvascular endothelial ...

... infection in vivo, stimulaties the secretion of IFN-gamma, IL17, IL6, TNF-alpha, and nitric oxide production by ...

... (PHA) blasts, induce PHA blasts to secrete IFN-gamma, and enhances the killing of K562 target cells by ...

... is not neutralized by antibodies against FGF, IL4, IL6, IFN-gamma, TGF-beta and TNF-alpha. See also: Fibroblast proliferation ...

... and concentrations of IL1, IL6, TNF-alpha, TNF-beta, IFN-gamma, TGF-beta-2. Copyright © 1997-2021. All rights ...

... . Its expression is upregulated in enterocytes by IL13 and IFN-gamma (Gronert et al, 1998). Sodin-Semrl et al (2000) have ...

... The protein neutralizes the biological activity of chicken IFN-gamma. The FPV016 protein also neutralizes the activity of duck ...

... and human IFN-gamma but not that of mouse and rat IFN-gamma. For other relevant entries see also the Pathogenicity/ ...

... endothelial cells produce Fractalkine in response to IFN-gamma (Imaizumi et al, 2000). Yoneda et al (2000) have reported ...

... with the pro-inflammatory cytokines TNF-alpha and IFN-gamma (Yoshida et al, 2001). Zujovic et al (2000) have found that ...

... and CD107a, and an increased ratio of NK-cells producing IFN-gamma versus IL10. Frenatin 2.1S enhances recruitment, activation ...

... GAIT complex: [IFN-gamma-activated inhibitor of translation complex] GAIT is a ...

... complex formed in human myeloid cells following exposure to IFN-gamma (for an overview see: Mukhopadhyay et al, 2009). The GAIT ...

... requires their phosphorylation, which is induced by IFN-gamma (Arif et al, 2009, 2011). EPRS has been shown to recognize ...

... et al, 2003). Mukhopadhyay et al (2008) have shown that IFN-gamma activates a kinase cascade in which DAPK1 [death-associated ...

... Galectin-3 knock-down dendritic cells also produce more IFN-gamma and less IL10 than control cells. The percentage of T-cells ...

... reported that galectin-7 inhibits the expression of IL2 and IFN-gamma in the T-cell line Jurkat cells, suggesting that galectin-7 ...

... gamma-IMCs: see: IFN-gamma-producing immature myeloid cells. For related information ...

... Gamma-Interferon: see: IFN-gamma. See also: IFN for general information about interferons. ...

... expression) specifically induced by treatment of cells with IFN-gamma (see also: IFN). GAF exists in the cytoplasm in a latent ...

... activated by phosphorylation immediately after binding of IFN-gamma to its receptor. Phosphorylation of GAF is mediated by a ...

... region of genes the expression of which is induced by IFN-gamma. This site overlaps with the interferon-stimulated response ...

... by various pro-inflammatory (TNF-alpha, IL1-beta, IL6, IFN-gamma) in human gastrointestinal epithelial cells, and ...

... of inflammatory cytokines such as IL6, IL8, MCP-1, and IFN-gamma (Zhu S et al, 2017). For other proteins (or fragments ...

... , hepatotropin) (La Rosa et al, 2000) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... expression of GCP-2 is induced by IL1 and downregulated by IFN-gamma. GCP-2 expression is induced in MG-63 cells (but not A549 ...

... by CD3 antibodies and suppresses production of IL2 and IFN-gamma by Th1 cells and IL4 and IL10 expression by Th2 cells. ...

... gIFN: abbr. for Gamma-Interferon. See: IFN-gamma. See also: IFN for general information about interferons. ...

... The supernatant of stimulated cells contain high levels of IFN-gamma and low levels of IL4 (Toledo et al, 1999). GK-1 peptide ...

... as causing increases in the levels of CD8 T-cells producing IFN-gamma, leading to tumor cell death (Piñón-Zá ...

... that has the ability to inhibit the secretion of TNF-alpha, IFN-gamma), IL6, and IL10 induced by lipopolysaccharide (LPS) in ...

... and necrosis induced by cytokines (IL1-beta, TNF-alpha and IFN-gamma) in beta-cells, which involves a signaling pathway that ...

... , endogenous pyrogens (see: EP), bacterial endotoxins, or IFN-gamma. Copyright © 1997-2021. All rights reserved by Dr H ...

... identified as a component of the so-called GAIT complex [IFN-gamma-activated inhibitor of translation complex]. In response to ...

... IFN-gamma, the enzyme is phosphorylated and released from the ...

... of the cells with Lactoferrin, prostaglandin E2, or IFN-gamma. GM-EF is not identical with IL1, IL4 or IL6 which are ...

... with a GNRH1 agonist leads to a marked increase in IFN-gamma and inhibition of IL4 production from lymphocytes of ...

... the agonist. The responsiveness of lymphocytes to produce IFN-gamma is increased markedly in cells cultured ex vivo from ...

... -proliferative factor] (Lavagna et al, 2002) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... of GOLPH2 has been shown to be regulated by cytokines, with IFN-gamma upregulating and TNF-alpha downregulating expression ( ...

... of IL12A, and inhibits the expression of TNF-alpha and IFN-gamma. Zhang W et al (2018) have reported that GOLPH2 is a ...

... IL12 production by dendritic cells and production of IFN-gamma produced by activated T-cells in response to IL12. GOLPH2 ...

... . Gu et al (2003) have shown that gp49B1 regulates the IFN-gamma responses of T-cells and NK-cells during viral infections ...

... cells stimulated with gp120 produce IFN-alpha and IFN-gamma, as well as several markers of IFN activity, such as Beta-2 ...

... cells expression of GPL is upregulated strongly by IFN-gamma. The ligand for this receptor is IL31. Dreuw et al (2004) ...

... immune responses characterized by the production of IFN-gamma (Supply et al, 1999). Lin et al (2010) have demonstrated ...

... . M-GRAM is not identical with IL1, IL2, IFN-alpha, IFN-gamma, G-CSF, or M-CSF, all of which do not induce a ...

... and Nilsen-Hamilton, 1998). They produce cytokines such as IFN-gamma, IL18 and IL27 (Croy et al, 2003). It has been suggested ...

... increased levels of type 1 interferons, TNF-alpha, and IFN-gamma, but are impaired with repect to phagocytosis. These cells ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... , F-IFN, IFF) receptors (Spicer and Alpizar, 1994) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Sarapik ...

... et al, 2012) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ) (Koks et al, 2010) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... et al, 2012) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) (Brannian ...

... 1993) • PUMA-G (protein upregulated in macrophages by IFN-gamma, HM74, HM74B, GPR109B, G-protein-coupled receptor-109B; ...

... GRMFT does not appear to be identical with IL1, IL2, IL3, IFN-gamma. The factor is probably not identical with various T-cell ...

... improves the clinical joint score and lowers serum IL6 and IFN-gamma levels. Chang et al (2017) have reported protective ...

... al (1989). HC11 expression in macrophages is inducible by IFN-gamma. HC11 (76 amino acids) belongs to the family of ...

... et al (1989). Its expression in macrophages is inducible by IFN-gamma. HC14 belongs to the family of chemotactic cytokines known ...

... stimulation by bacterial lipopolysaccharides, poly(I:C), IFN-gamma or CD40L. HCR is expressed also in CD34(+) cells in the ...

... ; growth hormone • IFN-alpha • IFN-beta • IFN-gamma • IFN-kappa • IFN-omega • IFN-tau &bull ...

... ] Some short-chain helical cytokines are • IFN-gamma • IL2 [interleukin-2] • IL3 [interleukin-3] & ...

... , produce significantly more of the chemokine CCL3 and IFN-gamma compared with Helios(+) nTregs. Despite increased cytokine ...

... and Helios(-) nTreg clones had an equal ability to produce IFN-gamma. Thus, lack of Helios expression does not exclusively ...

... , TNF-alpha, GM-CSF, G-CSF, IL1-alpha, and the interferons IFN-gamma, IFN-alpha, IFN-beta), various chemokines, as well as JAK- ...

... (IL6, TNF-alpha, IL12 and GM-CSF, IL2, IL4, IL10 and IFN-gamma), through NF-kappa-B) signaling, which probably promote ...

... cells • Tc10 cells • Tc17 cells • Tc17/IFN-gamma cells • Tc22 cells • T-cells • Tconv [ ...

... for CNTF, Epo, G-CSF, GM-CSF, IFN-alpha, IFN-beta, IFN-gamma, IL10, IL11, IL12, IL15, IL2, IL3, IL4, IL5, IL6, IL7, IL9 ...

... producer cells. They include IL1, IL2, TNF-beta and IFN-gamma. Some factors negatively regulate processes of ...

... T-cell NK1 receptors with high affinity and stimulates IFN-gamma production with a potency equal to that of Substance P ...

... availability in lymphocytes, modulates responsiveness to IFN-gamma and, hence, autoimmune responses. Tolosano et al (1999) ...

... ) (Pediaditakis et al, 2002; Zhou et al, 1999) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Fernandez ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... 2, IFN-alphaR2, IFNABR) (Rao HY et al, 2007) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... -induced co-stimulation also enhances the production of IFN-gamma and IL4 and causes increased TCR down-regulation, ...

... that NS4B contributes to immune evasion by blocking IFN-gamma receptor signal transduction-related genes. Einav S et ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... et al, 2007; Oie et al, 2006; Wolber et al, 2002) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Kvale and ...

... Brandtzaeg, 1993) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... T) (Yamaji et al, 2006) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... Lee et al, 2002) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... 2, IFN-alphaR2, IFNABR) (Radaeva et al, 2002) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Lord et ...

... al, 2001) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... (Sparna T et al, 2010) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... do not appear to proliferate in response to IL1, IL2, or IFN-gamma. They respond to LMW-BCGF (low molecular weight B-cell ...

... effect is greatly reduced by pretreatment of the cells with IFN-gamma. In the same cell line, expression of HIN-1 is upregulated ...

... induced selectively by bacterial lipopolysaccharides and/or IFN-gamma in alveolar macrophages. Rat Histogranin inhibits ...

... -2], purified from murine macrophages stimulated with IFN-gamma. MUMP-1 and MUMP-2 are active against Salmonella ...

... -3], purified from murine macrophages stimulated with IFN-gamma. MUMP-3 is active against Salmonella typhimurium, ...

... HIV1 replication. It is also not identical with IFN-beta, IFN-gamma, or TNF-alpha, which do not possess blocking activity. See ...

... receptor on T-cells, enhances the release of TNF-alpha and IFN-gamma from peripheral blood mononuclear cells stimulated by IL2. ...

... enhances the cytokine-induced production of TNF-alpha and IFN-gamma by NK-cells. IL4 downregulates IFN-gamma and TNF-alpha ...

... on resting monocytes but slightly enhances TNF-alpha and IFN-gamma secretion induced by IL15 monocyte stimulation. The viral ...

... medium but do not secrete IL1-beta, IL2, IL4, IL10, IL12 or IFN-gamma (Wagner et al, 1998). For an overview of other cell lines ...

... as a model of the functions of neutrophils. Interferon IFN-gamma, but not other interferons (see also: IFN), and also LIF, ...

... derived factor, which appears to be distinct from IL1, IL2, IFN-gamma, IFN-alpha, IL3, EPA, and GM-CSF, induces differentiation ...

... G is expressed by trophoblasts and macrophages activated by IFN-gamma (Chu et al, 1998). Yang et al (1996) have reported that ...

... macrophages express HLA-G, and that IFN-gamma increases expression. Blaschitz et al (1997) have reported ...

... membrane-bound HLA-G stimulates the release of TNF-alpha, IFN-gamma, and IL10 but reduces the release of IL3. Membrane-bound, ...

... by trophoblasts decreases the amounts of TNF-alpha and IFN-gamma released by decidual mononuclear cells, but does not affect ...

... of human peripheral blood mononuclear cells and inhibits IFN-gamma and IL6 production by these cells. For other proteins/ ...

... interferon, LyIFN-alpha, IFL) (Bulmer et al, 1990) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Berkowitz ...

... stimulating effect is potentiated strongly by TNF-alpha and IFN-gamma. Montemurro et al (2001) have reported that HP-NAP ...

... receptors on activated T-cells, causing decreased T-cell IFN-gamma release and altered T-cell-dependent inhibition of ...

... . These activities are not blocked by heparin or IFN-gamma. Gorgani et al (1997) have shown that human HRGP binds ...

... S100, myosin, and lactoferrin. Treatment of HSG cells with IFN-gamma results in the increased expression of the cell surface ...

... by diminishing the amount of EGF in the conditioned medium. IFN-gamma also increases MMP-2 and MMP-9 levels, which is blocked ...

... partially by an antibody against the IFN-gamma receptor. This effect is associated with a complete ...

... inhibition of the antiproliferative effect exerted by IFN-gamma. BB94, a synthetic MMP inhibitor does not alleviate this ...

... antiproliferative effect. IFN-gamma causes a concentration-dependent decrease in HSG cell ...

... alone has little effect but increases the expression of the IFN-gamma receptors. The two factors act synergistically to block ...

... cell growth reversibly. The antiproliferative effect of IFN-gamma alone and that of IFN-gamma and TNF-alpha in combination ...

... are blocked completely using an antibody to the IFN-gamma receptor. IGF-1, EGF, and insulin promote cell growth and ...

... the production of IGFBP3 and probably IGFBP4. TNF-alpha and IFN-gamma cause increased accumulation of IGFBP3, IGFBP4, and IGFBP5 ...

... in response to heat shock. The protein is acid-sensitive as IFN-gamma and temperature labile, unlike bovine IFN-alpha, IFN-beta ...

... and IFN-gamma. HSIF induces 2',5'-oligoadenylate synthetase activity and ...

... monoclonal antibodies), cytokine production (TNF-alpha, IFN-gamma, IL2, and IL4), and expression of cell activation markers ( ...

... with CD4(+) cells, but not by CD8(+) cells. HSF suppresses IFN-gamma activity produced by mitogen-stimulated peripheral blood ...

... monocytes. Expression is induced by IL4 or IL13 but not by IFN-gamma or IL2. IFN-gamma efficiently blocks Lsk induction by IL4 ...

... factor described by Giedlin et al (1986) is identical with IFN-gamma. Walker et al (1984) have described an Ia inducing ...

... tumor cell line P-388D1 after treatment with cloned murine IFN-gamma that induces the cell surface expression of Ia antigen on ...

... WEHI-3 cells (monocytes). This factor is not identical with IFN-gamma. Various pro-inflammatory cytokines are known to possess ...

... various extents. These factors include IL2, IL3, IL4, IL6, IFN-gamma, GM-CSF. TNF-alpha has been found both to enhance and also ...

... to inhibit MHC class 2 expression induced by IFN-gamma. Copyright © 1997-2021. All rights reserved by Dr H ...

... on dermal fibroblasts is increased by either IL1 or IFN-gamma. ICAM-1 monoclonal antibody interferes with the adhesion of ...

... shown that ICEBERG blocks secretion of IL1-beta induced by IFN-gamma or bacterial lipopolysaccharides in a monocytic cell line ...

... B-cell help in vivo. ICOS co-induces IL4, IL5, IL6, IFN-gamma, TNF-alpha, GM-CSF, and superinduces IL10. IL2 is typically ...

... IL13. Th1 cell-mediated inflammation of the lung mucosa and IFN-gamma secretion are not affected (Coyle et al, 2000, Tesciuba et ...

... in the production of IL4, but not in the production of IFN-gamma (McAdam et al, 2001, Dong et al, 2001). Shilling et al ( ...

... those of wild-type mice due to an impaired production of IFN-gamma (Holtschke et al, 1996). ICSBP may play a role in ...

... oxygen intermediates, all of which are inducible by IFN-gamma (Ko et al, 2002). Copyright © 1997-2021. All rights ...

... cells, and enhances the secretion of TNF-alpha, MCP-1 and IFN-gamma by human peripheral blood mononuclear cells compared with ...

... (2014) have reported that IE1 disrupts type 2 interferon (IFN-gamma) signaling. A complex role of IE1 has been reported by ...

... IFGR2: [IFN-gamma receptor 2] see: IFNGR2. Copyright © 1997-2021. All ...

... , but is strongly inducible in HL-60 and U937 with IFN-gamma (Trapani et al, 1992, 1994). IFI16 is expressed in cells ...

... is inducible on tumor cell lines by IFN-alpha and IFN-gamma. IFI17 expression appears to be correlated with the ...

... expression is observed in keratinocytes stimulated with IFN-gamma, TNF-alpha, or TGF-beta-1. Retinoids and vitamin D ...

... , macrophages, monocytes, and epithelial cells with IFN-gamma, IFN-alpha, or IFN-beta and is translocated to the nucleus ...

... cells. IRF1 also activates IFI35 expression in response to IFN-gamma. The protein has been shown to form heterodimers with B- ...

... with Nmi. CKIP-1 can be up-regulated dramatically by IFN-gamma and IL2 and form homodimer and homotrimer in vivo. The ...

... et al (1983), is induced by IFN-alpha, IFN-beta, and IFN-gamma in human fibroblasts and lymphoblastoid cells. The protein ...

... of IFIT3 induced by IFN-alpha, but not induced by IFN-gamma. Li Y et al (2015) have reported that porcine IFIT3 ...

... 1] IFITM1 has been identified by Young et al (2007) as an IFN-gamma induced gene that plays a key role in the antiproliferative ...

... action of IFN-gamma (Yang et al, 2007). The gene has been identified ...

... of IFITM1 blocks the antiproliferative effect of IFN-gamma, accelerates the cell growth rate, and confers ...

... reduces the growth-inhibitory capacity of both IFITM1 and IFN-gamma (Yang et al, 2007). Lickert et al (2005) have implicated ...

... of IFITM2 is inducible by IFN-alpha, IFN-beta, and IFN-gamma. The gene has been identified independently as fragilis3. ...

... site but most subtypes are not glycosylated. In contrast to IFN-gamma IFN-alpha proteins are stable at pH2. For a bioactive ...

... 30 % homology with other IFN-alpha subtypes. In contrast to IFN-gamma IFN-beta is stable at pH2. For a bioactive fragment of IFN- ...

... blocks the expression of HLA class 2 antigens stimulated by IFN-gamma. IFN-beta stimulates the activity of NK-cells and hence ...

... ] This type 1 interferon protein is co-expressed with IFN-gamma by the trophectoderm of the pig conceptus between day 12 ...

... , which is enhanced significantly in the presence of IFN-gamma. On pig cells IFN-delta binds to the same type I receptor ...

... IFNG: approved gene symbol for IFN-gamma [Interferon-gamma]. See also: IFN for general information ...

... IFN-gamma: Gamma-Interferon, abbr. gIFN. Approved gene symbol IFNG ...

... factor) or TRF (T-cell replacing factor) are due to IFN-gamma. SOURCES IFN-gamma is produced mainly by T-cells and ...

... the surface antigens CD4 and CD8. The synthesis of IFN-gamma is induced, among other things, by IL2, bFGF, and EGF. The ...

... synthesis of IFN-gamma is inhibited by 1-alpha,25-Dihydroxy vitamin D3, ...

... and CsA (Cyclosporin A). B-cells also produce IFN-gamma, and constitutive synthesis has been observed in many ...

... human B-cell lines. PROTEIN CHARACTERISTICS IFN-gamma is a dimeric protein with subunits of 146 amino acids. The ...

... protein is glycosylated at two sites. The pI is 8.3-8.5. IFN-gamma is synthesized as a precursor protein of 166 amino acids ...

... at position 97. The observed differences of natural IFN-gamma with respect to molecular mass and charge are due to ...

... under non-denaturing conditions are dimers and tetramers of IFN-gamma. Recombinant IFN-gamma isolated from Escherichia coli is ...

... for biological activity (see also: Recombinant cytokines). IFN-gamma contains two cysteine residues that are not involved in ...

... . At least six different variants of naturally occurring IFN-gamma have been described. They differ from each other by ...

... activities of these variants do not differ from recombinant IFN-gamma obtained from Escherichia coli. It has been proposed that ...

... artifacts. In contrast to IFN-alpha and IFN-beta IFN-gamma is labile at pH 2. IFN-gamma can exist in a form ...

... and may, therefore, exert juxtacrine growth control. IFN-gamma does not display significant homology with the other two ...

... interferons, IFN-alpha and IFN-beta. Murine and human IFN-gamma show approximately 40 % sequence homology at the protein ...

... masses between 70 and 160 kDa have been described for IFN-gamma. They are expressed on all types of human cells with the ...

... is observed in other cell types. The expression of the IFN-gamma receptor on human peripheral blood monocytes is ...

... significantly increased by GM-CSF. IFN-gamma receptors are N- and O-glycosylated and bind IFN-gamma with ...

... and the human receptor show a sequence homology of 52 %. IFN-gamma/ receptor complexes are rapidly internalized by endocytosis ...

... human chromosome 6 and therefore expressing the receptor IFN-gamma binds to this receptor without eliciting any biological ...

... responses. The cells respond to IFN-gamma if human chromosome 21 is also introduced into these cells ...

... molecule, is also species-specific. A soluble form of the IFN-gamma receptor has been described also. Soluble receptors have ...

... or act as transport proteins. BIOLOGICAL ACTIVITIES IFN-gamma has antiviral and antiparasitic activities and also ...

... proliferation of a number of normal and transformed cells. IFN-gamma synergises with TNF-alpha and TNF-beta in inhibiting the ...

... of various cell types. The growth inhibitory activities of IFN-gamma are more pronounced than those of the other interferons ( ...

... see: IFN). However, the main biological activity of IFN-gamma appears to be immunomodulatory in contrast to the other ...

... antiviral. In T-helper cells IL2 induces the synthesis of IFN-gamma and other cytokines. IFN-gamma acts synergistically with ...

... by specific antibodies also inhibits the synthesis of IFN-gamma. IFN-gamma thus influences cell mediated mechanisms of ...

... cytotoxicity. IFN-gamma is a modulator of T-cell growth and functional ...

... -60 can be induced to differentiate by a number of stimuli. IFN-gamma, but not other interferons (see: IFN), specifically induces ...

... differentiation of these cells into monocytes. IFN-gamma inhibits the growth of B-cells induced by IL4. IFN-gamma ...

... proliferation of human B-cells but not of murine B-cells. IFN-gamma also inhibits the production of IgG1 and IgE elicited by ...

... IL4 in B-cells stimulated by bacterial lipopolysaccharides. IFN-gamma regulates the expression of MHC class 2 genes and is the ...

... that stimulates the expression of these proteins. IFN-gamma also stimulates the expression of Ia antigens on the cell ...

... , neutrophils, and monocytes. In monocytes and macrophages IFN-gamma induces the secretion of TNF-alpha and the transcription of ...

... genes encoding G-CSF and M-CSF. In macrophages IFN-gamma stimulates the release of reactive oxygen species. IFN- ...

... by partial inhibition of the formation of osteoclasts. IFN-gamma inhibits the proliferation of smooth muscle cells of the ...

... such as stenosis following injuries of arteries. IFN-gamma inhibits the proliferation of endothelial cells and the ...

... and fibroblast growth factors (see: FGF) and PDGF. IFN-gamma specifically induces the transcription of a number of genes ...

... , KNOCK-OUT, AND ANTISENSE STUDIES The expression of IFN-gamma in the pancreas of transgenic mice has been shown to ...

... precipitate autoimmune diabetes. IFN-gamma produced locally in the pancreas of transgenic animals ...

... islet cells are formed continuously from duct cells. The IFN-gamma induced islet neogenesis is similar to embryonic islet ...

... islet development. Mice with a targeted disruption of the IFN-gamma gene have been developed by homologous recombination in ES ...

... major histocompatibility complex class 2 antigens. IFN-gamma deficient mice are killed by normally sublethal doses of ...

... cell activity is reduced in these mice. Mice lacking the IFN-gamma receptor have been created also by homologous recombination ...

... virus. Immunoglobulin isotype analysis reveals that IFN-gamma is required for a normal antigen-specific immunoglobulin ...

... G2a response. DETECTION AND ASSAY METHODS IFN-gamma can be detected by sensitive immunoassays. A specific ELISA ...

... test allows detection of individual cells producing IFN-gamma. Minute amounts of IFN-gamma can be detected indirectly by ...

... of the synthesis of IP-10 has been used also to measure IFN-gamma concentrations. A new bioassay employs induction of ...

... . NO production by RAW264.7 cells in response to murine IFN-gamma can be used also as a bioassay. Schein describes a ...

... quantitative rapid assay for IFN-gamma that is based on its ability to stimulate the activity of ...

... an immunoassay allowing rapid determination of the rate of IFN-gamma production under conditions preventing consumption/ ...

... USE AND SIGNIFICANCE Like the other interferons (see: IFN) IFN-gamma can be used as an antiviral and antiparasitic agent. IFN- ...

... doses. In spite of the antiproliferative activities of IFN-gamma hopes that this interferon may be of use in the treatment ...

... also with chemotherapy has been moderately effective only. IFN-gamma may be of value in the treatment of opportunistic ...

... atopic dermatitis. Experiments are in progress to insert IFN-gamma genes into human tumor cells by genetic engineering as a ...

... . The transduction of murine tumor cells with a functional IFN-gamma gene has been shown to lead to the rejection of the ...

... vaccines see also: Cytokine gene transfer). Treatment with IFN-gamma of a subgroup of patients with sepsis (see also: Systemic ...

... IFN-gamma-activated inhibitor of translation complex: see: GAIT ...

... IFN-gamma inducible secretoglobin: see: IIS. Copyright © 1997- ...

... IFN-gamma inducible protein 10: see: IP-10. Copyright © 1997- ...

... IFN-gamma-inducible protein gamma-2: This protein has been ...

... et al, 1991). It is expressed highly in response to IFN-gamma but not IFN-alpha. Sequence comparison shows that the ...

... IFN-gamma inducing factor: see: IGIF. See also: IFN-gamma. Copyright © 1997-2021. All rights reserved by Dr H ...

... IFN-gamma inducing factor binding protein: abbr. IGIFBP. See: IL18BP ...

... IFNgamma-MdC: [IFN-gamma-stimulated monocyte-derived cells] These cells constitute a ...

... the presence of CD4(+) T-cells expressing CD40L, M-CSF, and IFN-gamma. They express markers including F4/80, CD11b/c, CD86, and ...

... IFN-gamma-producing B-cells: see: Be1 cells. See also: IFN-gamma-producing innate B-cells. For related information of ...

... IFN-gamma-producing immature myeloid cells: abbr. gamma-IMCs. These ...

... from myeloid-derived suppressor cells. The cells produce IFN-gamma, depend on GM-CSF, and have been shown to play a protective ...

... of these cells ameliorates infection in wild-type and IFN-gamma deficient mice. The cells are not found in mice infected ...

... IFN-gamma-producing innate B-cells: This cell type, identified by ...

... CD11a and FCGR3 (CD16) and the production of high levels of IFN-gamma. This subpopulation of B-cells can promote macrophage ...

... activation via generating IFN-gamma, thereby facilitating the innate immune response against ...

... CD40 ligation, with the consequent induction of additional IFN-gamma production. For a cell type that may correspond to these ...

... IFN-gamma-R1: [IFN-gamma receptor-1] See: IFNGR1, which is the approved gene symbol ...

... IFN-gamma-R2: [IFN-gamma receptor 2] See: IFNGR2, which is the approved gene symbol ...

... IFN-gamma receptor-1: abbr. IFN-gamma-R1. See: IFNGR1, which is the approved gene symbol. In the ...

... IFN-gamma receptor 2: abbr. IFN-gamma-R2. See: IFNGR2, which is the approved gene symbol. ...

... IFN-gamma regulated human melanoma-associated antigen: This cell ...

... IFN-gamma-stimulated monocyte-derived cells: see: IFNgamma-MdC. For ...

... IFNGR1: [IFN-gamma receptor-1; interferon-gamma receptor 1; IFN-gamma-R1] This ...

... is the approved gene symbol for the type 1 IFN-gamma receptor. It is being referred to also as immune interferon ...

... this protein has been given the designation CD119. The IFN-gamma receptor is a heterodimeric protein consisting of the ...

... IFNGR2: [interferon-gamma receptor 2; IFN-gamma receptor 2; IFN-gamma-R2] This is the approved gene symbol ...

... for the signal transduction subunit of the IFN-gamma receptor. Older designations are IFGR2 and IFNGT1 [ ...

... interferon-gamma transducer 1]. The human IFN-gamma receptor (Novick et al, 1987; Aguet et al, 1988) is a ...

... ] This term has been used to refer to the receptor for IFN-gamma, which has been classified as a type 2 interferon. See ...

... , exposure to double-stranded RNA, or treatment with IFN-gamma or IFN-beta. IFN-kappa mRNA is expressed in resting ...

... cells and monocytes, and its expression is upregulated by IFN-gamma stimulation in monocytes. Administration of recombinant ...

... from monocytes. IFN-kappa does not induce the release of IFN-gamma by peripheral blood leukocytes. Scarponi et al (2006) have ...

... main human interferons are known as IFN-alpha, IFN-beta and IFN-gamma. IFN-alpha and IFN-beta as well as IFN-delta, IFN-omega, ...

... . A unique type 1 interferon is known as IFN-alphaomega. IFN-gamma has been designated Type 2 interferon (abbr. sometimes IFN- ...

... ), fibroblast interferon (IFN-beta) and immune interferon (IFN-gamma) are still in use. These names are derived from the main ...

... of the immune system. The human interferons IFN-beta and IFN-gamma are encoded by two different single genes while human IFN- ...

... surface of target cells. This receptor differs from that of IFN-gamma. Binding of an interferon to its receptor induces the ...

... specifically induced either by IFN-alpha and IFN-beta or by IFN-gamma. Some of the newly formed proteins are nucleases, synthases ...

... kDa] The expression of this protein is strongly induced by IFN-gamma in fibroblasts, macrophages, and epithelial cells. The ...

... peritoneal macrophages with M-CSF (but not IL3, TNF-alpha, IFN-gamma, and bacterial lipopolysaccharides) upregulates the ...

... IL1 receptor antagonist), IL2, IL4, IL6, IL7, TNF-alpha and IFN-gamma. They probably function as physiological regulators of ...

... elevates in uteri the levels of the Th1 cell cytokine IFN-gamma while reducing the Th2 cell cytokines IL4 and IL10. The ...

... IGIF: [IFN-gamma inducing factor] The new term IL18 (Interleukin-18; see ...

... after cell activation. IGIF is an activity that induces IFN-gamma in T-cells in mice treated with Propionibacterium acnes and ...

... IGIFBP: abbr. for IGIF binding protein, IFN-gamma inducing factor binding protein. This is a designation for ...

... proteins the expression of which is upregulated strongly by IFN-gamma in keratinocytes. The protein appears to be a processed ...

... IIF: [immune interferon] This interferon is identical with IFN-gamma. See also: IFN for general information about interferons. ...

... . Its expression in lymphoblast cells is augmented by IFN-gamma treatment. IIS is expressed in virtually all tissues, and ...

... ). IK factor inhibits HLA Class 2 antigen induction by IFN-gamma and also constitutive HLA-DR expression. IK plays a key ...

... cytokines including TNF-alpha, IFN-alpha, IFN-beta and IFN-gamma and also by bacterial endotoxins, viruses, mitogens, and ...

... the inhibition of IL1 synthesis caused by IFN-alpha and IFN-gamma, is mediated by an increase of intracellular cAMP levels. ...

... by treatment with bacterial lipopolysaccharides or IFN-gamma. The enzyme cleaves the 31 kDa precursor of human IL1-beta ...

... . In keratinocytes, its synthesis can be induced by IFN-gamma and TNF-alpha (Kumar et al, 2000). Its synthesis in vivo is ...

... in nude mice and SCID mice and in mice deficient in IL12, IFN-gamma, or FAS ligand. ILF7 confers substantial anti-tumor effects ...

... IL1F7b binds to the IL18 receptor but does not induce IFN-gamma production (Kumar et al, 2002). Sharma et al (2008) have ...

... cells. IL1-L1 also does not influence the production of IFN-gamma in response to IL18 in KG-1 cells. The approved gene ...

... shown to be dependent on cell density (Hattar et al, 2001). IFN-gamma modulates the production of IL1ra in activated human ...

... . The inhibitory effect of glucocorticoids is reversed by IFN-gamma through a mechanism dependent on endogenous IL1 production ...

... et al, 1994). Subcutaneous administration of IFN-alpha or IFN-gamma in humans has been shown to cause increases in circulating ...

... IL1ra and augments IL1ra expression induced by LPS and IL4. IFN-gamma suppresses the expression of IL1ra caused by IFN-beta and ...

... epithelial cells is upregulated in response to IL4, IL13, IFN-gamma. Ohguchi et al (1998) have reported that Activin A ...

... and IL2, PDGF, aFGF, bFGF, EGF, G-CSF, IL3, IL5, IL6, IFN-gamma, TNF-alpha and IL1ra itself have no effect. Sciacca et al ...

... cells. IL2 receptor expression of monocytes is induced by IFN-gamma, so that these cells become tumor-cytotoxic. In T-cells the ...

... and in tumor surveillance. IL2 stimulates the synthesis of IFN-gamma in peripheral leukocytes and also induces the secretion of ...

... other soluble mediators, including TNF-alpha, TNF-beta, and IFN-gamma. These effects may contribute to the antitumor activity of ...

... . It is not identical with TNF-alpha, IFN-alpha, or IFN-gamma. It inhibits the expression of the alpha subunit of the IL2 ...

... the expression of MHC class 2 molecules normally induced by IFN-gamma. IL3 induces the expression of complement factor C3a ...

... receptor antagonist), IL2, IL6, IL7, TNF-alpha, IGF, and IFN-gamma. The mechanisms of IL4 mediated intracellular signal ...

... switching induced by IL4 in B-cells is antagonized by IFN-gamma. The growth of multiple myelomas can be suppressed by IL4 ...

... to activation of the cells by bacterial endotoxins or IFN-gamma. IL4 synergises with Epo and G-CSF/Epo in the generation ...

... . Several cytokine mRNA such as those coding for IL5, IL6, IFN-gamma and also the IL4 receptor are found to be upregulated in ...

... receptor antagonist), IL2, IL4, IL7, TNF-alpha, IGF, and IFN-gamma. Some cells, including hematopoietic progenitor cells and ...

... also: Factor-dependent cell lines) can be inhibited also by IFN-gamma. IL6 may function also as an autocrine growth modulator for ...

... IL1 receptor antagonist), IL2, IL4, IL6, IGF, TNF-alpha and IFN-gamma. They probably function as physiological regulators of ...

... of IL8 is enhanced by Leukoregulin. The interferon IFN-gamma can function as a costimulator. The synthesis of IL8 is ...

... B-cells through a specific mechanism that is different from IFN-gamma, IFN-alpha, or prostaglandin E2 The intravenous ...

... inhibits the synthesis of a number of cytokines such as IFN-gamma, IL2 and TNF-beta in Th1 T-helper cell subpopulations of T- ...

... activity is antagonized by IL4. The inhibitory effect on IFN-gamma production is indirect and appears to be the result of a ...

... an inhibition of antigen presentation. In human monocytes IFN-gamma and IL10 antagonize each other's production and function. ...

... presence of accessory cells and reduces the production of IFN-gamma and IL2. Exogenous IL2 and IL4 inhibit the proliferation- ...

... inhibitory effect but do not influence the production of IFN-gamma. In macrophages stimulated with bacterial ...

... lipopolysaccharides IFN-gamma increases the synthesis of IL6 by inhibiting the production ...

... depletion appears to involve the increased production of IFN-gamma since coadministration of neutralizing anti-IFN-gamma ...

... responses by specifically inhibiting the synthesis of IFN-gamma and other cytokines that would kill the host cell ...

... of enhanced parasite proliferation. Levels of IL12 and IFN-gamma in sera of these animals are four- to sixfold higher than ...

... from control animals and spleen cells secrete more IFN-gamma than normal splenocytes. If lymphocytes expressing CD4, ...

... of the Th1 T-helper cell type IL12 induces the synthesis of IFN-gamma and IL2, and TNF. TNF-alpha also appears to be involved in ...

... against TNF-alpha. IL12 and TNF-alpha are costimulators for IFN-gamma production with IL12 maximizing the IFN-gamma response; the ...

... production of IL12, TNF, and IFN-gamma is inhibited by IL10. In Th2 T-helper cells IL12 reduces ...

... IL4 also in the presence of antibodies directed against IFN-gamma. Murine IL12 has been shown to alter CD4(+) subset ...

... but not completely lacking in the ability to produce IFN-gamma following endotoxin administration and to mount a Th1 T- ...

... leukemia. The ability of IL12 to induce the synthesis of IFN-gamma and to stimulate the proliferation of resting peripheral ...

... effects in vivo, which are, at least in part, mediated by IFN-gamma. IL12 therefore seems to be a potential candidate also for ...

... IL12. The homodimer completely suppresses production of IFN-gamma by T-cells activated with IL12. This may be a mechanism ...

... IL8, IL10, IL12) and chemokines (MIP-1, MCP) in response to IFN-gamma or bacterial lypopolysaccharides. IL13 enhances the ...

... ligand (see: TRAP). IL13 synergizes with IL2 in regulating IFN-gamma synthesis in large granular lymphocytes. IL13 has been ...

... astrocytes and microglial cells in response to IL1-beta, IFN-gamma, or TNF-alpha and may thus play a role in T-cell mediated ...

... , THP-1. It does not induce expression of IL1-alpha, IL6, IFN-gamma, or G-CSF in these cells. Intraperitoneal injection of ...

... , THP-1. It does not induce expression of IL1-alpha, IL6, IFN-gamma, or G-CSF in these cells. Yamaguchi et al (2007) have ...

... protein of 24 kDa has been identified originally as IGIF (IFN-gamma inducing factor). It encodes an inducer of IFN-gamma ...

... . Some of them are inactive dimers while others have weak IFN-gamma inducing activity. IL18 type 2 is a fragment of IL18 that ...

... possesses little activity as an inducer of IFN-gamma. This variant is bound to IgM in plasma and is found at ...

... the receptor for FAS ligand, FAS antigen, is upregulated by IFN-gamma (Watanabe-Fukunaga et al, 1992) that itself is induced by ...

... cytokine. IL18 induces activated B-cells to produce IFN-gamma that inhibits IgE production (Yoshimoto et al, 1997). IL18 ...

... has been shown to strongly augment the production of IFN-gamma by T-cells and NK-cells (Micallef et al, 1996). The ability ...

... of IL18 to enhance IFN-gamma production by NK-cells is dependent on the presence of IL12 ...

... by osteoblastic stromal cells acts via GM-CSF and not via IFN-gamma to inhibit osteoclast formation. Morel et al (2001) have ...

... a variety of pathogens, mainly due to the induction of IFN-gamma expression. IL18 plays a critical role in the defense ...

... , and mononuclear phagocytes, and its ability to induce IFN-gamma expression in smooth muscle cells, suggests a paracrine pro ...

... major. Infected mice produce significantly lower levels of IFN-gamma and larger amounts of IL4 compared with similarly infected ...

... splenic T-cell proliferation, decreased synthesis of IFN-gamma and TNF-alpha, but increased production of IL4. Wei et al ...

... ] Also being referred to as IGIFBP [IGIF binding protein, IFN-gamma inducing factor binding protein]. The international non- ...

... IL18 receptor binding and inhibits the production of IFN-gamma induced by IL18 in KG-1 cells. Novick et al (2001) have ...

... human urine. This glycoprotein blocks the production of IFN-gamma and IL8 induced by IL18. Novick et al (1999) and Kim et al ...

... strongly induced by IL12. The effect is mediated mainly by IFN-gamma derived predominantly from NK-cells. IFN-gamma, IL2, IL15, ...

... no effect. Paulukat et al (2001) have demonstrated that IFN-gamma induces expression and release of IL18BPa from various ...

... in the presence of IL4 or IL13 but is unaffected by IFN-gamma. GM-CSF directly induces IL19 gene expression in monocytes ...

... CD40 and IL4. In the absence of anti-CD40, IL21 induces IFN-gamma production and inhibition of IL4 induced IgE production. ...

... IFN-gamma-mediated inhibition of human IgE synthesis by IL21 is ...

... activated by antibodies against CD3. Both forms upregulate IFN-gamma production in NK-cells and activate the signal transducers ...

... T-cell activation. IL21 enhances the cytotoxic activity and IFN-gamma production by activated murine NK-cells but does not ...

... further innate responses. IL21 enhances the proliferation, IFN-gamma production, and cytotoxic function of CD8(+) effector T- ...

... . Human IL23 has been shown to stimulate the production of IFN-gamma by PHA blast T-cells and memory T-cells. It also induces ...

... IL23 are completely rejected. IL12-p40 also suppresses IFN-gamma production of antigen-stimulated splenocytes and IL23 ...

... induces secretion of high levels of IL6, TNF-alpha, and IFN-gamma and low levels of IL1-beta, IL12, and GM-CSF from human ...

... IL22 receptor, is 10-50 times more potent than endostatin, IFN-gamma, and IP-10. Soluble IL24 inhibits VEGF induced angiogenesis ...

... mononuclear cells to secrete cytokines (IL6, TNF-alpha, and IFN-gamma, inhibits the formation of blood capillaries in a Chicken ...

... IL26 gene maps to chromosome 12q15 in the vicinity of the IFN-gamma gene and the gene encoding IL22 (IL-TIF) (Dumoutier et al, ...

... HCV-infected patients and enhances production of IFN-beta, IFN-gamma, IL1-beta, and TNF-alpha by human NK-cells in a manner ...

... IL27 strongly synergizes with IL12 to trigger production of IFN-gamma by naive CD4(+) T-cells. IL27 has been shown to ...

... immunity, which is mediated mainly through CD8(+) T-cells, IFN-gamma, and T-bet but not through STAT4 (Hisada et al, 2004). ...

... . This protection is associated with reduced levels of IFN-gamma and some of its signaling proteins. In vivo blockade of ...

... after mitogen stimulation, in human epithelial cells by IFN-gamma, and in NK-cells after exposure to the combination of IL12 ...

... is not seen in animals lacking TNF-alpha receptor type 1 or ifn-gamma. Immune inflammatory hypernociception involves a ...

... signaling cascade from IL33 to TNF-alpha to IL1-beta to IFN-gamma to endothelin-1 to prostaglandin. Pushparaj et al (2009) ...

... of anti-osteoclastogenic cytokines (GM-CSF, IL4, and IFN-gamma) in the serum. In vitro IL33 directly inhibits osteoclast ...

... -induced arthritis, as well as reduced production of IL17, IFN-gamma, and TNF-alpha. Administration if IL33 exacerbates collagen ...

... concomitant suppression of IL17 production but enhanced IFN-gamma synthesis. Collison et al (2007) have reported that the two ...

... cells, which can be enhanced upon stimulation with IFN-gamma, LPS, or CD40L. The conditioned medium of these cells has ...

... cell lines compared to normal cell lines. TNF-alpha and IFN-gamma stimulation increases IL35 expression in human cancer cells ...

... apoptosis induced by serum starvation, TNF-alpha, and IFN-gamma stimulation through the up-regulation of FAS and concurrent ...

... by inducing inflammation through the production of IL17 and IFN-gamma and are thought to contribute to chronic inflammatory ...

... factors (T-bet and Eomes) and are incapable of IFN-gamma production or cytotoxic responses. cNK-cells show a CD56 ...

... single-copy gene maps to chromosome 12q15 (90 Kb from the IFN-gamma gene, and 27 Kb from the AK155 gene encoding another IL10- ...

... In mice the gene is located also in the same region as the IFN-gamma gene. In BALB/c and DBA/2 mice the gene is a single copy ...

... -10. The gene maps to human chromosome 6q24, 35 kb from the IFN-gamma R1 gene. It is expressed in various tissues with maximal ...

... reduces the expression of inflammatory mediators such as IFN-gamma. Copyright © 1997-2021. All rights reserved by Dr H ...

... Immune interferon: This interferon is identical with IFN-gamma. See also: IFN for general information about interferons. ...

... receptors: [immune interferon receptor] see: IFNGR1 [IFN-gamma receptor-1], IFNGR2 [IFN-gamma receptor 2]. Copyright © ...

... Immuneron: Recombinant IFN-gamma (Biogen). Copyright © 1997-2021. All rights reserved ...

... ) Immunoregulin TP1 inhibits the secretion of IFN-gamma (IFN-gamma) and the monocyte chemoattractant chemokine CCL2, and ...

... tissues and its expression is upregulated specifically by IFN-gamma in monocytes (THP-1 and U937 cells). INCA has been shown to ...

... INF-gamma: This abbr. is used frequently for IFN-gamma. Copyright © 1997-2021. All rights reserved by Dr H ...

... TNF-alpha. Other pro-inflammatory mediators include LIF, IFN-gamma, OSM, CNTF, TGF-beta, GM-CSF, IL11, IL12, IL17, IL18, IL8 ...

... or the activation of antigen receptors. In this sense, IFN-gamma-producing innate B-cells, Be1 cells [type-1 B-effector ...

... needs the activation of antigen receptors. In this sense, IFN-gamma-producing innate B-cells, Be1 cells [type-1 B-effector ...

... ; IFN-delta-2 • IFN-delta-8 • IFN-epsilon • IFN-gamma • IFN-gamma-inducible protein gamma-2 • IFN- ...

... -epsilon] • IFNE1 [interferon-epsilon 1] • IFNG [IFN-gamma] • IFNK [IFN-kappa] • IFNL1 [IFN-like 1] • ...

... • Tanapoxvirus 38 kDa protein • Tanapoxvirus IFN-gamma/IL2/IL5 binding protein • Tanapoxvirus TNF binding ...

... nucleotidohydrolases • viral dUTPases • viral IFN-gamma/IL2/IL5 binding protein • viral inhibitor peptide of ...

... et al, 2013) are defined by their capability to produce IFN-gamma, and the expression of the T-box transcription factors (TF ...

... ILC1s cells are characterized by their capacity to secrete IFN-gamma responding to IL12, IL15, and IL18 (Gordon et al, 2012, ...

... , 2014). Intraepithelial type 1 ILCs are a unique subset of IFN-gamma-producing cells responding to IL12 and IL15 and also ...

... . group 3 ILCs] (Spits et al, 2013). ILC3s cells produce IFN-gamma, IL17, and IL22 following stimulation with IL1-beta and ...

... et al, 2011). Innate lymphoid cells produce IL17, IL22, and IFN-gamma in response to IL23 and mediate innate colitis. Increased ...

... interferons and individual entries for IFN-beta, IFN-delta, IFN-gamma, IFN-kappa, IFN-omega, IFN-tau (see: TP-1 [trophoblast ...

... and individual entries for IFN-alpha, IFN-delta, IFN-gamma, IFN-kappa, IFN-omega, IFN-tau (see: TP-1 [trophoblast ...

... about interferons and individual entries for IFN-alpha, IFN-gamma, IFN-omega, IFN-tau (see: TP-1 [trophoblast protein-1]). ...

... Interferon-gamma: see: IFN-gamma. See also: IFN for general information about interferons ...

... ). Its expression is inducible by IFN-alpha, IFN-beta, and IFN-gamma (Lewin et al, 1991). Expression of the encoded protein is ...

... highly inducible by IFN-alpha and IFN-gamma. The protein has been shown to be identical with IFI17 [ ...

... interferons and individual entries for IFN-beta, IFN-delta, IFN-gamma, IFN-omega, IFN-tau (see: TP-1 [trophoblast protein-1]). ...

... interferons and individual entries for IFN-alpha, IFN-beta, IFN-gamma, IFN-kappa, IFN-tau (see: TP-1 [trophoblast protein-1]). ...

... substantial amounts of type 1 interferons and IL12 or IFN-gamma, depending on cell activation stimuli. They also express a ...

... entries for IFN-alpha, IFN-beta, IFN-delta, IFN-epsilon, IFN-gamma, IFN-kappa, IFN-lambda-1, IFN-lambda-2, IFN-lambda-3, ...

... interferons and individual entries for IFN-alpha, IFN-beta, IFN-gamma, IFN-omega. See also: hormones/neuropeptide MiniCOPE ...

... to measure in vivo serum concentrations of IL4 and IFN-gamma in mice. These assays have been developed also for mouse ...

... was identified in extracts of keratinocytes stimulated by IFN-gamma by its ability to bind to Chinese hamster ovary cells ...

... from RAW264.7 mouse macrophage-like cells stimulated with IFN-gamma and bacterial lipopolysaccharides shares 63 % identity with ...

... cells, keratinocytes, and fibroblasts, is induced by IFN-gamma and TNF-alpha. Human neutrophils produce IP-10 in response ...

... to IFN-gamma in combination with either TNF-alpha or bacterial ...

... and this response is blocked by IL10 and IL4. IFN-gamma, alone or in association with agonists such as fMLP, IL8, G ...

... Gasperini et al, 1999). Sauty et al (1999) have shown that IFN-gamma strongly induces expression of IP-10, and the two ...

... induction of the synthesis of IP-10 is used as an assay of IFN-gamma activities. IP-10 has been detected in keratinocytes, ...

... inflammatory agents, and in particular after injection of IFN-gamma, and may play an important role in the response of liver ...

... when stimulated by bacterial lipopolysaccharides than by IFN-gamma / IL2. It has been suggested that IP-10 may play an ...

... -gamma), significantly inhibits induction of expression by IFN-gamma of IP-10 and the chemokines mig and I-TAC. Teruya- ...

... dendritic cells, which then generate Th1 cells producing IFN-gamma. This IRA B-cell-dependent Th1 cell skewing manifests in an ...

... of the IRAK gene. These mice display a dramatic decrease of IFN-gamma mRNA expression in Th1 cells. These effects are due to ...

... NF-kappa-B is also not induced. A reduced production of IFN-gamma by natural killer cells, but no loss of cytolytic function ...

... , virus infection, and IFN-alpha but not by IFN-gamma. IRF7 binds to the ISRE [interferon-stimulated response ...

... of MHC class 1 and guanylate-binding protein, two primary IFN-gamma target genes. It also interferes with the induction of the ...

... (see also: gene expression). The different strengths of IFN-gamma induced promoter activities mediated by ISRE are modulated ...

... factor). The expression of ISGF-3 is not induced by IFN-gamma. Its synthesis is enhanced, however if cells treated with ...

... IFN-gamma are subsequently treated with IFN-alpha. IRF1 (interferon ...

... of encephalomyocarditis virus replication by IFN-alpha and IFN-gamma has been found to be impaired in cells from mice carrying a ...

... (Künzi and Pitha, 1996), and significantly less by IFN-gamma (Loeb and Haas, 1992). ISG15 is one of the most robustly ...

... synthesis in response to IFN-alpha or IFN-beta, but not IFN-gamma. ISG15 is released from primary cultures of peripheral ...

... . An antiserum against ISG15 blocks the secretion of IFN-gamma from CD3(+) T-cells. D’Cunha J et al (1996) have ...

... s) are required. ISG15 treatment also induces expression of IFN-gamma in T-cells, but not in NK-cells. Hare et al (2015) have ...

... -stimulated genes. ISG15 is a potent cytokine inducing IFN-gamma production, a function independent of ISGylation. ISG15 ...

... in particular - greatly reduces the production of IFN-gamma by lymphocytes, including natural killer cells, probably ...

... elicit a strong synergistic effect on the secretion of IFN-gamma from peripheral blood mononuclear cells. ISG15 alone ...

... directly to CD11a in vitro, and LFA-1 inhibition blocks IFN-gamma secretion. Splenocytes from CD11a knock-out mice do not ...

... respond to ISG15. ISG15 also enhances secretion of IL10 and IFN-gamma by NK-cells, indicating a broader role for ISG15 in ...

... a consequence of isotype switching. Some cytokines such as IFN-gamma and IFN-alpha can act both as inducers or inhibitors of ...

... isotype switching. IFN-gamma is known to inhibit the ability of IL4 to enhance IgG1 and ...

... IgE synthesis. IFN-gamma also inhibits IgG1, IgG2b, IgG3 secretion but can stimulate ...

... to the Th17 cell lineage in vitro. The presence of IFN-gamma during CD4(+) T-cell polarization inhibits isthmin ...

... by IFN. Human neutrophils produce I-TAC in response to IFN-gamma in combination with either TNF-alpha or bacterial ...

... and this response is blocked by IL10 and IL4. IFN-gamma, alone or in association with agonists such as fMLP, IL8, G ...

... al, 1999). Stimulation of astrocytes with a combination of IFN-gamma and IL1 increases levels of I-TAC mRNA approximately 400, ...

... , thymus, and spleen. Sauty et al (1999) have shown that IFN-gamma strongly induces expression of I-TAC, and the two ...

... of murine I-TAC mRNA is induced in RAW264.7 macrophages by IFN-gamma or bacterial lipopolysaccharides and is weakly induced by ...

... and IFN-beta. Induction of murine I-TAC in these cells by IFN-gamma is enhanced markedly by costimulation with bacterial ...

... -gamma), significantly inhibits induction of expression by IFN-gamma of I-TAC and the chemokines mig and IP-10. Copyright © ...

... produce large amounts of nitric oxide when activated with IFN-gamma and a low concentration of bacterial lipopolysaccharides ( ...

... manner while addition of IL10 at the same time or after IFN-gamma activation is without effect. Treatment of J774 cells with ...

... IFN-gamma induces synthesis of IL12 mRNA expression. J774 is used in ...

... no longer respond to the antiviral effect of IFN-beta and IFN-gamma. M1 leukemic cells stably expressing JAB are also resistant ...

... to growth arrest caused by IFN-gamma and IFN-beta. A similar effect is seen in IFN-resistant ...

... be completely defective in interferon responses (IFN-alpha, IFN-gamma) (Müller et al, 1993). Like other members of the ...

... domain in JAK1, but not the kinase domain is crucial for IFN-gamma induced STAT1 activation (Raivola et al, 2019). Eletto et ...

... kinase activity, is mandatory for JAK2 activation after IFN-gamma stimulation leading to STAT1 phosphorylation. Rodig et ...

... necessary for the interaction with the IFN-alpha receptor, IFN-gamma receptor, IL10RA, IL2RB, and IL4RA. Sakamoto et al (2016 ...

... ; for mechanistic insights see also: Brooks et al, 2014). IFN-gamma: Watling et al (1993) have reported that JAK2 is essential ...

... for signal transduction processes of the IFN-gamma receptor but is not required for responses to IFN-alpha and ...

... completely abolishes the production of Th1 cells expressing IFN-gamma, whereas the percentage of Foxp3(+) regulatory T-cells is ...

... . Impaired Th1 cell development is caused by the attenuated IFN-gamma / STAT1 signalling, IL12 / STAT4 signalling, and repressed ...

... ) have reported that treatment of cells with TNF-alpha and IFN-gamma appears to cause a redistribution of the protein, which may ...

... is induced also by M-CSF, IL1, EGF, bacterial endotoxins, IFN-gamma, and synthetic dsRNA. In Osteoblasts and epithelial cell ...

... factors IL1, IL2, IL4, IL6, TNF-alpha, TNF-beta, IFN-gamma, or to HMW-BCGF (Namalwa), alone or in combination (see ...

... than membrane anchoring has been described for GM-CSF, IL3, IFN-gamma, SCI (stem cell inhibitor), and LIF. Since these specific ...

... do not respond to IL1, IL2, IL3, IL4, IFN-alpha, IFN-beta, IFN-gamma, G-CSF, GM-CSF. The cells have been used in bioassays of ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... IFN-alphaR2, IFNABR) (Kinoshita et al, 2009) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... Watanabe et al, 2009) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) (Muhl et ...

... et al, 2001) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... 2, IFN-alphaR2, IFNABR) (Taylor et al, 1996) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... the human myelomonocytic cell line, KG-1, which produces IFN-gamma in response to human IL18. This response is blocked ...

... concentrations of murine IL18 by assaying the amount of IFN-gamma produced by these cells. For an overview of other cell ...

... et al, 1982). The other KHF activity may be due to IL5 and IFN-gamma (see also: Th1 cytokines, Th1 cytokines) (Takatsu et al, ...

... . KLF4 expression is induced markedly in response to IFN-gamma, LPS, or TNF-alpha and decreased by TGF-beta-1 in ...

... PAI-1. KLF4 knock-down markedly attenuates the ability of IFN-gamma, LPS, or IFN-gamma plus LPS to induce the iNOS promoter, ...

... The receptor mediates cytotoxicity and cytokine secretion (IFN-gamma) in NK-cells via its interaction with CLEC2A, for which ...

... effect is not due to SCF. Antibodies against TGF-beta-1, IFN-gamma, MIP-1-alpha and IL4, which are detectable in the ...

... of KPMM2 cells. Cell growth is inhibited by IFN-alpha and IFN-gamma. KPMM2 cells may be useful to investigate the pathogenesis ...

... It decreases the expression of pro-inflammatory cytokines (IFN-gamma, TNF-alpha, IL6, and IL17A), chemokines (LARC (CCL20), ...

... -beta (see: IL1), IL3, G-CSF, GM-CSF, IFN-alpha, IFN-beta, IFN-gamma, or TNF-alpha. Polyclonal rabbit antibodies against IL6 ...

... , and IL8. Pretreatment with phorbol esters, IL1-beta, or IFN-gamma increases the level of G-CSF, GM-CSF, and M-CSF in the ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... and Cohen, 1991; Werner-Wasik et al, 1989) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... T) (Li et al, 2002) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... method they are negative for the expression of MIP-1-beta, IFN-gamma, IL2, IL3, IL4, IL5, IL9. IL11, and LIF mRNA levels are ...

... of primary rat astrocytes with lipopolysaccharide (LPS) and IFN-gamma increases intracellular lactosylceramide levels and induces ...

... mediator, showing that in astrocytes stimulated by IFN-gamma and TNF-alpha it mediates the expression of adhesion ...

... have reported that most CD8(+) clones producing IL4 but not IFN-gamma (i.e., with a Th2 like profile) also express LAG-3 and ...

... IL7, IL12, but not by IL4, IL6, IL10, TNF-alpha, TNF-beta, IFN-gamma, and correlates with intracellular IFN-gamma production in ...

... -stimulated CD4(+) human T-cells leads to the production of IFN-gamma (Annunziato et al, 1996). LAG-3 has been shown to play a ...

... of dendritic cells to stimulate the proliferation and IFN-gamma response by allogeneic T-cells. Avice et al (1999) have ...

... cells (granulocytes, NK-cells, CD4(+) T-cells, CD8(+) IFN-gamma expressing cells), and the release of immunoregulatory and ...

... cytotoxic mediators by infiltrating leukocytes (IFN-gamma, TNF-alpha, IL1-beta, CXCL5, CXCL9, CXCL10, CXCL11, CCL5, ...

... be enhanced also by in vitro treatment with TNF-alpha or IFN-gamma. TNF-alpha appears to promote the migration of lymphocytes ...

... tumor (see also TIL, tumor infiltrating lymphocytes) while IFN-gamma increases the expression of the major histocompatibility ...

... in monocytes activated by GM-CSF and IL3) but not by IFN-gamma. Several inhibitors of LAK cell activity may play an ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... factor receptor) (Kurz et al, 2002) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... Stoitzner et al, 2001) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... Wang et al, 2002) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... from macrophage fusion induced by T-cell cytokines such as IFN-gamma (Gasser and Most, 1999). These cells are being referred to ...

... interactions with CD40 and its ligand (CD40L) as well as IFN-gamma are essential for the formation of Langhans giant cells. ...

... The combination of exogenous soluble CD40L and IFN-gamma efficiently replaces the role of T-cells in Langhans giant ...

... expression of CTLA-4 and IL10 and decrease expression of IFN-gamma, TNF-alpha, and granzymes. Adoptive transfer of CD103(+) ...

... 52 kDa and is distinct from receptors for IL8 or IFN-gamma. It has been identified as CCR5. The LD78-beta isoform is ...

... SCID mice to produce IL12, IL18, and high levels of IFN-gamma. LeIF also potentiates the cytotoxic activity of natural ...

... . The protein also causes a significant downregulation of IFN-gamma, IL2, and IL12 secretion and thus probably interferes with ...

... not neutralized by antibodies to G-CSF, GM-CSF, IFN-alpha, IFN-gamma, TNF, urokinase, and tissue plasminogen activator. For ...

... -1. Some of the "recruiting activity" can be attributed to IFN-gamma. Copyright © 1997-2021. All rights reserved by Dr H ...

... 2, IFN-alphaR2, IFNABR) (Sanz et al, 2013) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ) (Sanz et al, 2013) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... Sanz et al, 2013) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... antibodies directed against TNF-alpha, TNF-beta, IFN-alpha, IFN-gamma, or IL1-alpha (see: IL1), alone or in combination, do not ...

... of a LT-beta receptor-Fc or a TR2-HVEM-Fc fusion protein. IFN-gamma greatly enhances apoptosis mediated by LIGHT. LIGHT is not ...

... blood lymphocytes with LIGHT causes the release of IFN-gamma. Morel et al (2000) have shown that the expression of LIGHT ...

... zVAD-fmk do not block apoptosis induced by LIGHT and IFN-gamma in MDA-MB-231 cells, showing that the activation of ...

... bacterial lipopolysaccharides, IL1, IL6, but not by IL4 or IFN-gamma (Tsukada et al, 1996). LIL factor binds to an element ...

... beta gene (see: IL1) that resembles the activation site for IFN-gamma. Lemmink et al (2001) have identified LIL factor in ...

... leukemia cells and monocytes after stimulation with IL6 or IFN-gamma and shown that it consists of STAT1 and STAT3 proteins. ...

... cells selectively suppress the expansion of cells producing IFN-gamma and promote the outgrowth of Th2 cells expressing IL4 ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) (Liu J et ...

... preparation used frequently in these studies contained IL2, IFN-gamma, TNF-alpha and GM-CSF. One particular LMW-BCGF produced by ...

... . These cells produce increased concentrations of IFN-gamma and IL4 (Budd et al, 1991). One of the underlying causes of ...

... with a more limited up-regulation of both TNF-alpha and IFN-gamma expression, as prominent features of the autoimmune ...

... . Davidson et al (1991) have reported hypersecretion of IFN-gamma and TNF-alpha by stimulated CD4(+) T-cells of MRL/lpr mice ...

... B-cells and upregulation of LRRK2 after stimulation with IFN-gamma. Examination of lamina propria tissue from Crohn disease ...

... and dexamethasone, upregulated by IL4 or TGF-beta, but not IFN-gamma. High levels of IL4 (100 and 1000 U/mL) inhibit Ltn ...

... through a decreased production of Th1 cytokines (IL2, IFN-gamma) and decreased IL2RA receptor expression. CD4(+) T-cell ...

... T-cell stimulation, the expression of Ly6C correlates with IFN-gamma production (Walunas et al, 1995). Hänninen et al ( ...

... IL3 mRNA. LGF contains no detectable IFN-alpha, IFN-beta, IFN-gamma or GM-CSF activity and purified EGF, TGF-beta, and ...

... 500-fold excess of other cytokines such as IL1-beta, IL18, IFN-gamma, and TNF-alpha. M3 blocks the interaction of chemokines ...

... by gamma-Interferon) (see also: Monokines). See also: IFN-gamma. Copyright © 1997-2021. All rights reserved by Dr H ...

... factor. The main factor responsible for MAF activity is IFN-gamma. Some of the MAF activity is due to GM-CSF or M-CSF, IL3, ...

... reversibly blocks the enhanced oxygen metabolism induced by IFN-gamma, the production of nitrogen oxides, the capacity to kill ...

... TR9, Forssman antigen, MOMA-1, MOMA-2, Monts-4, SER-4), and IFN-gamma-stimulated macrophages (H-2Ia, LFA-1, ICAM-1, 158.2, MBR-2 ...

... having undergone cell activation in response to LPS or IFN-gamma. Classical M1 macrophages have a pro-inflammatory phenotype ...

... activation of macrophages by Th1 cytokines (which includes IFN-gamma and TNF-alpha) is referred to as type 1 activation (Ma et ...

... polarized further by differentiation factors such as LPS, IFN-gamma, which cause M1 polarization, or IL4 and IL13, which cause ...

... overall survival. Duluc D et al (2009) have reported that IFN-gamma reverses the immunosuppressive and protumoral properties ...

... factor; M1 macrophage reprogramming factors], which may be IFN-gamma and low serum concentrations (Rey-Giraud F et al, 2012) ...

... those observed after treatment with lipopolysaccharides and IFN-gamma. Chaussabel et al (2003) have compared gene expression ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... ) (Jiang and Dhib-Jalbut, 1998; Kadl et al, 2010) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Amber et ...

... 2009; Ishida et al, 2008; Yang Z et al, 2013) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ) (Nichols et al, 2009) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) (Corbaz ...

... Kadl et al, 2010) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... 2008) • PUMA-G (protein upregulated in macrophages by IFN-gamma, HM74, HM74B, GPR109B, G-protein-coupled receptor-109B; ...

... produce effector cytokines (IL4, IL5, IL10, TNF-alpha, and IFN-gamma) after activation via MR1 (Kawachi et al, 2006; Croxford et ...

... can represent up to 45 % of liver lymphocytes. They produce IFN-gamma and Granzyme B as well as high levels of IL17 after phorbol ...

... . All MAIT-cell subsets produce comparable levels of IFN-gamma, TNF-alpha, and IL17A; the CD4(+) population produces more ...

... , which begin to produce the cytokines IL4, IL5, and IFN-gamma. Deiters et al (2003) have reported that MALP-2 induces ...

... immune responses, shown by a decrease in the production of IFN-gamma and IL17A, respectively. In the DNBS model of colitis MAM ...

... inhibits production of monocyte chemoattractant protein-1. IFN-gamma increases the concentrations of IL6, MCP-1, and M-CSF and ...

... , which is not observed when the cells are preactivated by IFN-gamma. Adusu et al (1994) have reported that the leukotoxin ...

... 2000). The toxin itself, and also IL1-beta, TNF-alpha, and IFN-gamma have been shown to increase expression of LFA-1 (CD11a) on ...

... by up-regulation of the inflammatory cytokines TNF-alpha or IFN-gamma. Following only CD8(+) T-cell depletion marginal zone ...

... is not identical with IL2, IL3, IL4, IL5, IL6, IL7, IL9, IFN-gamma, TNF-alpha, TNF-beta, GM-CSF, G-CSF, M-CSF, Epo, LIF, or ...

... vitro treatment of peritoneal cell-derived mast cells with IFN-gamma and IL4 induces surface expression of mature MHC class 2 ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... 2011; Inomata N et al, 2005; Johnson M et al, 2018) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Burd et ...

... ; Gupta et al, 1996; Bulanova et al, 2009) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ; Kakeda M et al, 2014) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... Z et al, 2018) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) (Hu Y et ...

... resting T-lymphocytes to proliferate and to produce IFN-gamma. The activity of MBF is not neutralized by antibodies to ...

... , suggesting a role as inhibitors of both IL10 and IFN-gamma signaling. Niki et al (2009) have reported that MC/9 cells ...

... murine IL18 with high affinity and inhibits IL18 mediated IFN-gamma production in a dose-dependent manner. A related protein ...

... IL1, IL2, IL4, GM-CSF, G-CSF, M-CSF, IFN-alpha, IFN-beta, IFN-gamma, NGF, EGF, serum fibronectin, heparin, or a number of ...

... ) and a long-term T-cell clone. MCIF-2 synergizes with IFN-gamma in inducing macrophage tumor cytotoxicity; IFN-gamma and ...

... MCIF-2 alone are ineffective. It appears that IFN-gamma serves as the priming factor and MCIF-2 as the triggering ...

... lipopolysaccharides, and IL1, but not by IL2, TNF, or IFN-gamma. In mesangial cells the synthesis and release of MCP-1 is ...

... in peripheral blood mononuclear cells are increased by IFN-gamma and decreased by IL13. MCP-3 is produced by a variety of ...

... such as bacterial lipopolysaccharides or TNF-alpha. IFN-gamma and IL4 synergize with TNF-alpha and IL1 in inducing MCP-4 ...

... of effector T-cells / memory T-cells and produce IFN-gamma in response to T-cell receptor stimulation. Macrophages ...

... . The synthesis of M-CSF can be induced by IL1, TNF-alpha, IFN-gamma, GM-CSF and PDGF. Prostaglandins, glucocorticoids, TGF-beta ...

... by antibodies directed against TNF-alpha, TNF-beta and IFN-gamma. For other entries pertaining to cell death mechanisms see ...

... possess anti-HIV1 activity, including IL10, IL12, IL16, IFN-gamma, and alpha-defensins (Mikulak et al, 2009). Copyright © ...

... in the affinity of EGF for its receptor. Human IFN-beta and IFN-gamma, which exhibit little antiviral and antiproliferative ...

... name recognizes a cell surface antigen on melanoma cells (IFN-gamma regulated human melanoma-associated antigen). Hayoz et al ( ...

... ). pokeweed mitogen, CSF1, GM-CSF, IL1, IL2, IL5, IL6, IL7, IFN-gamma, TGF-alpha, TNF-alpha, NGF, or Epo do not substitute for ...

... ) responses. To a lesser extent the protein mat also block IFN-gamma (Shaffer et al, 2003). Yokota et al (2003) have reported ...

... suppresses STAT1 dimer formation, which then suppresses the IFN-gamma signaling pathway. For other relevant entries see also the ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... IFN-alphaR2, IFNABR) (Krasagakis et al, 1991) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... et al, 1990; Satomi et al, 2002; Singh et al, 1996) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (La Porta ...

... and Comolli, 2000) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... LCF) (Wang et al, 2002) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... et al, 2008) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... and T-bet but express EOMES. Both cell types can produce IFN-gamma. Virtual memory T-cells are capable of antigen-independent ...

... cytokine production and lytic activity and can produce IFN-gamma when stimulated with a combination of IL12, IL15 and IL18 ( ...

... have reported that human memory-like NK-cells have enhanced IFN-gamma production and cytotoxicity against leukemia cell lines or ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... 2, IFN-alphaR2, IFNABR) (Allam et al, 2009 •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... C) (Iyoda et al, 2010) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... et al, 2010) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) (Muhl et ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... -alpha; HSP89-beta) (Arbeiter et al, 2001) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... et al, 2000, 2007) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... by resting fibroblasts and keratinocytes treated with IFN-gamma. Significant over-expression of meteorin-like is seen in ...

... cytokines (including TNF-alpha, IL17A, IL12, IL4, IL1-beta, IFN-gamma, and TGF-beta). Knock-out mice lacking expression of ...

... IL4. The activity of IL4 is stimulated considerably by IL6, IFN-gamma and GM-CSF. The MFF activity of the conditioned medium of ...

... with a reduction in IL10 in the spleen but an increase in IFN-gamma production in the spleen and atherosclerotic arteries. The ...

... . Its synthesis in macrophages is specifically induced by IFN-gamma. mig in turn is related to a protein called KC the ...

... human IL1 (IL1-alpha and IL1-beta), IL2, IL3, IL4, IFN-gamma, IFN-beta, G-CSF, or recombinant murine IL3, IL4, IL5 do ...

... with IFN-alpha, IFN-beta, TNF, IL2, IL4, IL5 and IL7. IFN-gamma shows significant MHC AF activity and the activity is ...

... partially blocked by antibodies against IFN-gamma. Purified MHC AF preparations do not have any activity in ...

... /encephalomyocarditis virus (EMC) IFN bioassays and anti-IFN-gamma affinity columns do not retain MHC AF activity. Copyright & ...

... by IL1-beta, TNF-alpha, IL2, and M-CSF, but not by IFN-gamma or bacterial lipopolysaccharides. Its expression is ...

... decreases expression of IL1-beta, TNF-alpha, GM-CSF, and IFN-gamma. Lankoff et al (2004) have reported that microcystin-LR ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... et al, 1997; Kim et al, 2002; Lalive et al, 2005) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (De Simone ...

... 2002; Xiao et al, 1997; Dimayuga et al, 2005) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ) (Nichols et al, 2009) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) (Re et al ...

... , 2002) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... have been described to possess MIF activity, including TNF, IFN-gamma, IL1, IL2, GM-CSF (see also: LIF (leukocyte migration ...

... nitric oxide production by macrophages primed with IFN-gamma. Administration of soluble bovine serum albumin or human ...

... specifically induced in macrophages and in other cells by IFN-gamma, but not by IFN-alpha or bacterial lipopolysaccharides. ...

... Human neutrophils produce mig in response to IFN-gamma in combination with either TNF-alpha or bacterial ...

... and this response is blocked by IL10 and IL4. IFN-gamma, alone or in association with agonists such as fMLP, IL8, G ...

... tumor cell lines express mig in response to treatment with IFN-gamma and bacterial lipopolysaccharides (Sun et al, 1999). Horton ...

... extracellular matrix component hyaluronan synergize with IFN-gamma in inducing the expression of mig in mouse macrophages. ...

... inflammatory reactions. Sauty et al (1999) have shown that IFN-gamma strongly induces expression of IP-10, and the two ...

... -gamma), significantly inhibits induction of expression by IFN-gamma of mig and the chemokines IP-10 and I-TAC. mig is highly ...

... also not rejected in knock-out mice lacking expression of IFN-gamma while injection of mig directly into the grafts restores T- ...

... inflammatory stimuli, such as LPS, TNF-alpha, IL6, and IFN-gamma. Wells et al (2008) have reported that MINCLE is an ...

... induced interferon: This interferon is identical with IFN-gamma. See also: IFN for general information about interferons. ...

... cytokines, including TNF-alpha, IL6, IL17, IL1-beta, IFN-gamma and MCP-1 (Zhang et al, 2018). Copyright © 1997-2021 ...

... in vitro production of nitric oxide induced by cytokines (IFN-gamma, TNF-alpha) or PMA in human leukocytes. Utrera-Barillas D ...

... On its own, it induces the production of IL1-beta, IL2, and IFN-gamma, IL5, IL6, and IL10. In combination with phorbol 12- ...

... myristate 13-acetate it inhibits production of IL1-beta, IFN-gamma, IL5 and IL6 but increases production of IL2 and IL10. ...

... cytokines. It induces the over-expression of the ILl-beta, IFN-gamma, IL2, IL4, and IL10 intracellular cytokines. Phorbol 12- ...

... 13-acetate + MLIF inhibits Th1 cytokine production (IFN-gamma) and increases Th2 cytokines (IL4 and IL10) in CD4(+) T- ...

... . The co-expression of the cytokine and chemokine receptors IFN-gamma / CCR5 and IL1-beta / CCR5 is inhibited by Phorbol 12- ...

... . The cytotoxic activity of the pro-inflammatory cytokine IFN-gamma in hepatic inflammation is strongly connected to the ...

... apoptosis in macrophages induced by lipopolysaccharide and IFN-gamma (Watanabe et al, 2013). Kondoh T et al (1999) have ...

... in vivo. Nakamura et al (1992) have reported that IFN-gamma enhances the expression of cell surface receptors for MNSF ...

... cells also respond (slightly) to IL2, IL4, IL6, IL9, and IFN-gamma. The cells also respond to IL4 and TNF-alpha. The cells ...

... colony formation of MO7E cells is enhanced significantly by IFN-gamma (see also: Colony formation assay). TPO (thrombopoietin) ...

... , IL8, IL10, TNF-alpha, TGF-beta, EGF, GM-CSF, IGF-1, PDGF, IFN-gamma. The activity of this factor is not blocked by antibodies ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... 2002; Fantuzzi et al, 2001; Marckmann et al, 2004) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Barcova ...

... et al, 1998; Kim et al, 2005) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... (Li H et al, 2000) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... F et al, 2012) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... upon viral infection has been shown to depend on IFN-gamma derived from CD8(+) cytotoxic T-cells and the release of ...

... Manz, 2016). de Bruin et al (2012) have reported that IFN-gamma induces monocytopoiesis and inhibits neutrophil development ...

... cells in the hematopoietic stem cell niche respond to IFN-gamma derived from cytotoxic T-cells with release of IL6 that ...

... in monocytes by IL1-beta and, to a lesser extent, by IFN-gamma. Transcripts are found in RNA extracted from normal human ...

... express class 1 and class 2 H-2k antigens after exposure to IFN-gamma. MRL104.8a cells can maintain immature double-negative ...

... blocks nitric oxide production induced by endotoxins, and IFN-gamma plus endotoxin, IL2, or TNF-alpha. MSP induces ...

... cytokines, including TNF-alpha, IL6, IL17, IL1-beta, IFN-gamma and MCP-1 (Zhang et al, 2018). Copyright © 1997-2021 ...

... , 2001). The stimulation of neutrophils by IL8 (CXCL8) and IFN-gamma induces MT6-MMP release, whereas stimulation and induction ...

... domain of human and mouse receptors for interferon-gamma (IFN-gamma). M-T7 specifically binds rabbit IFN-gamma and inhibit its ...

... . It also inhibits the biological activity of extracellular IFN-gamma with an affinity that is comparable to the affinity between ...

... cognate ligands. M-T7 does not bind either human or murine IFN-gamma. Since IFN-gamma is one of the key regulatory cytokines in ...

... . Binding of human RANTES to M-T7 can be competed by rabbit IFN-gamma. Heparin effectively competes the interaction of M-T7 with ...

... RANTES but not with rabbit IFN-gamma. M-T7 may function by modulating interactions between ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... , F-IFN, IFF) receptors (De Vos et al, 2001) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... 2010) • PUMA-G (protein upregulated in macrophages by IFN-gamma, HM74, HM74B, GPR109B, G-protein-coupled receptor-109B; ...

... cytokines (IL1-alpha, TNF-alpha, IFN-alpha, IFN-beta, and IFN-gamma). Myeloblastin antibodies bind to protease-activated ...

... by myeloid suppressor cells in response to exogenous IFN-gamma, autocrine production of IFN-gamma. The process also ...

... cells. Their suppressor activity partially depends on IFN-gamma stimulation. Suppressor activity requires cell contact and ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... human emc and Id related) (Izumi et al, 2006) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... the cytotoxicity of NK-cells and induces production of IFN-gamma. For additional information on CD antigens see also: CD ...

... stages of differentiation. Treatment of the cells with IFN-gamma enhances the expression of HLA class 2 and myc without ...

... of IL2, IL4, IL5, IL6, GM-CSF, and a moderate amount of IFN-gamma. The cells support the self-renewal of B1-cells and ...

... marrow largely suppress the production of Th1 cytokines (IFN-gamma, IL2) and Th2 cytokines (IL4). A natural suppressor cell ...

... colonic epithelial cell apoptosis induced by TNF-alpha and IFN-gamma and is also protective in a murine experimental colitis ...

... levels of Growth hormone and Thyrotropin in others. IFN-gamma has been shown to inhibit corticostatin releasing hormone ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... protein p204) (Dawson and Trapani, 1995) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... Ge D and You Z, 2008) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... production of inflammatory cytokines including TNF-alpha, IFN-gamma, IL6, and chemokine MCP-1. It is thought that its presence ...

... blood mononuclear cells does not alter production of IL4 or IFN-gamma, or the expression of the cell activation markers HLA-DR, ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... , IFF) (Tamassia et al, 2008; St-Onge et al, 2009) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Ethuin et ...

... et al, 2002; Adib-Conquy M et al, 2008) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ; Kakeda et al, 2014) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... et al, 2008) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... 2010) • PUMA-G (protein upregulated in macrophages by IFN-gamma, HM74, HM74B, GPR109B, G-protein-coupled receptor-109B; ...

... produce lower amounts of IL3, IL15, GM-CSF, TNF-alpha and IFN-gamma (Kontgen et al, 1995). Knock-out mice lacking expression of ...

... -1 regulates NK-cell function by modulating NKp44-induced IFN-gamma production or cytotoxicity. It also modulates IFN-gamma ...

... blocks signaling of the receptors for IFN-alpha and IFN-gamma. For other relevant entries see also the Pathogenicity/ ...

... blocks signaling of the receptors for IFN-alpha and IFN-gamma. For other relevant entries see also the Pathogenicity/ ...

... in tumor surveillance, immunity against viruses, and IFN-gamma secretion (Colucci et al, 2003). NK-cells are cytotoxic ...

... to be responsible for cytokine production, primarily IFN-gamma and TNF-alpha, in addition to other cytokines and ...

... more of the transcription factors T-BET and EOMES, produce IFN-gamma, and are cytotoxic, whereas stage 4a cells express more ROR ...

... antibodies neutralizing IL4. These cells produce IL10 and IFN-gamma. NK2 cells are obtained when NK-cells are grown in IL4 in ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... 2, IFN-alphaR2, IFNABR) (Hunter et al, 1997) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Arase et ...

... ; Bellora F et al, 2012; Lund H et al, 2012) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... et al, 2013) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... that they are effector-memory cells. The cells also produce IFN-gamma, but not IL2, upon interaction with the specific HCMV UL40- ...

... in vitro than wild-type NK-cells and also secrete less IFN-gamma upon target cell stimulation, NKLAM-deficient mice also ...

... . NKp80 ligation augments CD3-stimulated degranulation and IFN-gamma secretion by Effector Memory T-cells. Engagement of NKp80 ...

... IL1, IL4, IL6, IL7, IL8, IL9, IL10, IL11, IL12, IFN-alpha, IFN-gamma, MIP-1-alpha, TGF-beta, LIF, TNF-alpha, and gp130. ...

... -22. NKR-LTi cells that do not express ROR-gammat-t release IFN-gamma and are potent inducers of inflammatory colitis. NKR-LTi ...

... cells causes the rapid production of cytokines, including IFN-gamma and IL4. The cells can be activated by a number of ...

... of CD4(-) NKT-cells selectively produce the Th1 cytokines IFN-gamma and TNF-alpha, and expressed NKG2d, a marker associated ...

... cells produce high amounts of IL4 and moderate amounts of IFN-gamma. A widely used and most potent agonist for cell activation ...

... high levels of CD49, are CD69(-), are high producers of IFN-gamma after stimulation but do not produce IL4 (Stenström M ...

... produce large quantities of IL4 and substantial amounts of IFN-gamma upon cell activation. Both cell types also differ in the ...

... of NKT1-cells, leading to impaired iNKT-cell derived IFN-gamma in vitro and in vivo. Drees C et al (2017) have reported ...

... , NKT-cells can make typical Th1 cytokines (such as IFN-gamma, TNF-alpha), Th2 cytokines (such as IL4, IL10, and IL13), ...

... profile can be skewed either towards a predominance of IFN-gamma (Wilson et al, 1998; Arase et al, 1996) or towards IL4 ( ...

... production by NKT-cells ceases considerably earlier than IFN-gamma production (Crowe et al, 2003). IFN-gamma production by NKT ...

... human hepatic Valpha24(+) T-cells are potent producers of IFN-gamma and TNF-alpha, but not IL2 or IL4 (Kenna et al, 2003). ...

... CD278) (Kaneda et al, 2005; Buonfiglio et al, 2000) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Chen and ...

... et al, 2007) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... et al (2010) have identified NLRC5 as target gene of IFN-gamma and a mediator of antiviral signaling pathways mediated by ...

... IFN-gamma in an autocrine loop following infection of fibroblasts ...

... in lymphoid as well as epithelial cell lines induced by IFN-gamma requires NLRC5 and knock-down of NLRC5 expression ...

... 2006) have reported that nociceptin enhances TNF-alpha and IFN-gamma transcripts in the spleen when injected prior to challenge ...

... the nociceptin precursor gene show diminished TNF-alpha and IFN-gamma mRNA induction in the spleen following antigen challenge. ...

... express ovalbumin peptide. These cells also show heightened IFN-gamma responses from cocultured ovalbumin-specific CD4(+) T-cells ...

... ) and is able to produce IL4 and IL3, but not IL2 and IFN-gamma, in response to the engagement of Fc receptors by IgE, IgG1 ...

... IL3 is not mimicked by IL1, IL2, IL5, IL6, IL7, GM-CSF, or IFN-gamma (Le Gros et al, 1990). Non-B/non-T-cells identified as ...

... increased by NT-4/5 and slightly by NT-3. bFGF, CNTF, and IFN-gamma have no effect on NPY expression in these cells (Takei et ...

... with the small peptides AcSDKP; pEEDCK and is distinct from IFN-gamma, TNF-alpha, TNF-beta, TGF-beta, MIP-1-alpha, MIP-2-alpha, ...

... , IL2, the expression of IL2 receptor, and the synthesis of IFN-gamma. Addition of IL2 to the culture fully reverses the ...

... from IL1-alpha (see: IL1), IL2, IL3, IL4, IL5, IL6, GM-CSF, IFN-gamma, and TNF-alpha. The factor enhances the maturation and ...

... the highest level of induction by interferons (IFN-alpha, IFN-gamma) (Sanda et al, 2006). Like OAS1, the OAS2 enzyme plays a ...

... and induces differentiation (Suzuki et al, 1990, 1992). IFN-gamma and/or TNF-alpha suppress the primary and secondary colony ...

... cells from lysis by NK-cells, and inhibits production of IFN-gamma. Murine OCIL has been demonstrated to inhibit killing of ...

... precursors, CFU-GM, bone marrow cells, and osteoblasts. IFN-gamma enhances OIP-1 expression in these cells and OIP-1 inhibits ...

... on human keratinocytes in vitro upon stimulation with IFN-gamma. Shen et al (1983) have reported that OKM5 recognizes cell ...

... , hepatotropin) (Thewke DP and Seeds NW) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ;rout N et al, 2010) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... al, 1997, 1998, 1999; Shin et al (2000) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... and Raine, 2004) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... and Raine, 2004) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... M for some cell lines is synergised by TGF-beta and IFN-gamma. It promotes the growth of human fibroblasts, vascular ...

... Th1 cell immune response characterized by the induction of IFN-gamma in a dose depend manner. Co-administration of Oreochromicin ...

... -3. Oreochromicin-2 and Oreochromicin-3 enhance in vitro IFN-gamma production in Concanavalin A primed splenocytes from na& ...

... , peripheral blood monocytes and keratinocytes. IFN-gamma levels in sheep tissues infected with an IL10 deletion ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... 2, IFN-alphaR2, IFNABR) (Grewal et al, 2000) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Yu KJ et ...

... al, 2017) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ; Tokuda et al, 2004) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... a mechanism independent of RANKL and its receptor, RANK. IFN-gamma and IFN-beta are also important negative regulators in ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... 2, IFN-alphaR2, IFNABR) (Fox et al, 2003) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... et al, 1996) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... oxide synthesis induced by the inflammatory mediators IFN-gamma and bacterial lipopolysaccharides in primary mouse kidney ...

... capable of replacing the IL2 requirement for induction of IFN-gamma in mouse spleen cell cultures (Johnson et al, 1985). ...

... and is biologically active on human NK-cells, increasing IFN-gamma production and activation marker expression induced by IL12 ...

... IL12 in murine macrophages. p43 also increases the level of IFN-gamma production in antigen-primed lymph node cells (CD4(+) T- ...

... such as IL4 and IL5 and reduce Th1 type cytokines such as IFN-gamma and IL2. In vivo, administration of PACAP in antigen- ...

... immunized mice reduces the numbers of cells secreting IFN-gamma and enhances the numbers of cells secreting IL4 (Delgado et ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... protein 70) (Velez-Granell et al, 1994) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ) (Ni J et al, 2013) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... receptor 2, IFN-alphaR2, IFNABR) (Baumert JT et al, 2006) IFN-gamma receptors (Baumert JT et al, 2006; Fitzner B et al, 2007; ...

... homeostasis. Expression of PANDER is up-regulated by IFN-gamma, a cytokine implicated in the pathogenesis of type 1 ...

... these knock-out mice produce significantly less IL17 and IFN-gamma in ex vivo recall collagen stimulation assays compared with ...

... virus type A replication through the production of IFN-gamma. Compared with wild-type mice, PAR2 knock-out mice are more ...

... and increased CCL5 levels concentration but decreased IFN-gamma levels in the bronchoalveolar lavages. Holzhausen et al ...

... expression. These animals also have reduced expression of IFN-gamma, IL2, IL3, IL17), GM-CSF, and TNF-alpha. Maharshak et al ( ...

... -out animals together with reduced T-cell proliferation and IFN-gamma production. Demyelination and axonal injury in response to ...

... • Tanapoxvirus 38 kDa protein • Tanapoxvirus IFN-gamma/IL2/IL5 binding protein • Tanapoxvirus TNF binding ...

... ] • viral Golgi anti-apoptotic protein • viral IFN-gamma/IL2/IL5 binding protein • viral IL1-beta binding ...

... ) in these cells. The factor also induces production of IFN-gamma, TNF-alpha, and IL6 in natural killer cells or T-cells. ...

... not seem to be identical with IL1, IL2, IL4, IL6, IL12, IFN-gamma, TNF-alpha, GM-CSF. Copyright © 1997-2021. All rights ...

... -2 [B-cell growth factor-2], EGF, TGF-beta, IFN-beta, or IFN-gamma. The factor is identical with murine IL6 (Nordan et al, ...

... display enhanced proliferation and production of IL10 and IFN-gamma (Dong et al, 1999). Human CD4(+) T-cells express PD-1, ...

... immunosuppression, inhibiting T-cell proliferation and IFN-gamma production in vitro. The secPDL1 variant is expressed by ...

... , and thymus. Monocytes express the ligand in response to IFN-gamma. Mouse T-cells stimulated with antibodies against CD3 and ...

... CD4(+) Th1 T-cell proliferation and production of IFN-gamma. For other entries pertaining to cell death mechanisms see ...

... -alpha but not in response to IL6, MCP-1, M-CSF, GM-CSF, or IFN-gamma (Alles et al, 1994). Pentraxin is expressed in stimulated ...

... and murine cumulus oophorus cells (Salustri et al, 2004). IFN-gamma inhibits the expression of the protein in monocytes ( ...

... and dendritic cells. These mice also have reduced levels of IFN-gamma, IL12, and increased levels of IL4, which can be normalized ...

... derived from these animals appear to be more responsive to IFN-gamma and produce higher amounts of nitric oxide in response to ...

... IFN-gamma, TNF-alpha, and LPS. Rovere et al (2000) have reported ...

... , the disorder is associated with increased production of IFN-gamma and TNF-alpha, proliferation and hyperactivation of T-cells ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... -loop-helix protein 24) (Song W et al, 2005) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... that the murine Period2 regulates the daily rhythm of IFN-gamma. Fu et al (2002) have reported that mice deficient in the ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... Y et al, 2010; Mitsuhashi M et al, 2011) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... pH2-labile interferon: This interferon is identical with IFN-gamma. See also: IFN for general information about interferons. ...

... Th1 cells and Th2 cells and downregulates the production of IFN-gamma in stimulated Th1 cells. Ph8 peptide does not induce any ...

... ). It is a factor of 20-30 kDa that is not identical with IFN-gamma. Copyright © 1997-2021. All rights reserved by Dr H ...

... 1988, 1986). The factor is not identical with IFN-alpha and IFN-gamma. Copyright © 1997-2021. All rights reserved by Dr H ...

... . In response to inflammatory cytokines such as IL6, M-CSF, IFN-gamma or TNF-alpha, normal CD34(+) CD38(-) hematopoietic stem ...

... T-cells to express higher levels of Th1 cytokines (IFN-gamma) and lower levels of IL10 in comparison with parental LLC-1 ...

... Liu F et al, 2001; Arimura et al, 2009) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... in vivo or exposure of cells to IFN-alpha, IFN-beta, or IFN-gamma induces PI9 expression in murine hepatocytes. In human ...

... expression becomes upregulated in response to IFN-alpha, IFN-gamma, and TNF-alpha. Medema et al (2001) have reported that the ...

... of STAT1. PIAS-1 selectively regulates a subset of IFN-gamma or IFN-beta inducible genes by interfering with the ...

... populations (Wong et al, 2004). Signaling in response to IFN-gamma and Wnt family agonists is modestly subnormal (Roth et al, ...

... cytokines and growth factors (IL2, IL3, IL4, IL6, IL7, IFN-gamma) (Bachmann and Moroy, 2005; Allen et al, 1997). In human T- ...

... emc and Id related) (Kofler et al, 2002) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... binding protein-1) (Wang H et al, 1999) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... overexpressed in preeclampsia. Its secretion is induced by IFN-gamma and EGF. The introduction of antisense oligonucleotides ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... 2, Ly60, CD102) (Diacovo et al, 1994) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... A effectively suppresses the ability of NK-cells to produce IFN-gamma. Placental PLP-A expression is reciprocal to mesometrial ...

... decidua expression of IFN-gamma. Increased expression of PLP-A by the placenta coincides ...

... with the decline of IFN-gamma content in the mesometrial decidua adjacent to the placenta ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... helix-loop-helix protein 24) (Keating et al, 2006) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Wallace ...

... and Howie, 1999) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... -2, Anti-death protein) (Shi S et al, 2008) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... **-6 M). ACTH has been shown also to inhibit production of IFN-gamma by interfering with T-helper cell functions. Corticotropin ...

... enhance proliferation of T-cells and production of IL2 and IFN-gamma. Beta-Endorphin also inhibits expression of the IL2 ...

... of T-cell chemotactic factors, inhibit production of IFN-gamma by cultured human peripheral blood mononuclear cells, and ...

... and immunomodulating cytokines (IL1, IL6, TNF-alpha, IL2, IFN-gamma, IL4, IL13) as well as the expression of costimulatory ...

... CD4(+) T-cells proliferate more and produce excess IL2 and IFN-gamma but reduce IL10 after T-cell receptor stimulation. Gong ...

... in Th2 cells compared with Th1 cells, and PRDM1 attenuates IFN-gamma production in CD4 cells activated under nonpolarizing ...

... ) immunization. Lack of PRDM1 in CD4 T-cells increases IFN-gamma, T-bet, and BCL6 mRNA. Shapiro-Shelef M et al (2003) ...

... resembling Tr1 cells in that they produce IL10 and IFN-gamma. PRDM1-deficient effector T-cells fail to produce IL10, and ...

... activation. PRDM1 coordinately suppresses the release of IFN-gamma, TNF-alpha, and TNF-beta through direct binding to multiple ...

... of PRDM1 expression leads to enhanced production of IFN-gamma and TNF-alpha but does not alter cytotoxicity, whereas ...

... , the peptide increases IL4, IL5, IL10, and IL2, TNF-alpha, IFN-gamma, and GM-CSF. Thus, physiologic concentrations of the ...

... with deceased cytotoxicity of the cells induced by LPS and IFN-gamma. The effects of Dynorphin A(1-17) cannot be prevented with ...

... G-CSF treated mice were deficient in the ability to make IFN-gamma, and the CD8(+) cells produced with pGM-CSF treatment had ...

... mediators include members of the IL20 family, IL33 LIF, IFN-gamma, OSM, CNTF, TGF-beta, GM-CSF, IL11, IL12, IL17, IL18, IL8 ...

... and demyelination, and decreases the production of IFN-gamma and IL17A cytokines in lymph node cells while increasing ...

... IL10. In vitro, prokineticin-2 increases IFN-gamma and IL17A and reduces IL10 in splenocytes activated against ...

... by macrophages. Knock-out animals show expression levels if IFN-gamma receptor and TLR4 comparable to those found in wild-type ...

... . Levels of SOCS11 and SOCS3 proteins, known to suppress IFN-gamma and LPS signaling, are higher in macrophages from knock-out ...

... calcium levels, TNF-alpha, UV, Gamma-irradiation, or IFN-gamma (Berra et al, 1997; Shareef et al, 2007; Affar et al, 2006 ...

... protein upregulated in macrophages by IFN-gamma: see: PUMA-G. Copyright © 1997-2021. All rights ...

... -1. Pseudo-ICE blocks secretion of IL1-beta induced by IFN-gamma or bacterial lipopolysaccharides in a monocytic cell line. ...

... in plasma transaminase activities, and the release of TNF, IFN-gamma, IL2, and IL6 into the circulation. Cell death in the liver ...

... NK-cell activation in a feedback manner. PTAG inhibits IFN-gamma and granzyme B expression of NK-cells in cell-cell contact ...

... PUMA-G: [protein upregulated in macrophages by IFN-gamma] This murine protein has been identified by Schaub et al ( ...

... this protein is upregulated in macrophages in response to IFN-gamma. PUMA-G protein is most similar to the human orphan G- ...

... PYNOD. Dendritic cells from these mice elicit sub-optimal IFN-gamma production by antigen-specific CD4(+) T-cells compared to ...

... IL12 production is also evident in vivo and affects IFN-gamma production by T-cells. Upon Mycobacterium tuberculosis ...

... mediated IL12 production by dendritic cells is critical for IFN-gamma induction in T-cells and promotes the host defense against ...

... the elimination of PYPAF1 reduces IL18 and adipose tissue IFN-gamma expression. Jha et al (2010) have show that the ...

... encephalomyelitis produce less IL18 and also show reduced IFN-gamma and IL17 production. The resistance of PYPAF1 knock-out ...

... regulated by lipopolysaccharides and interferons (IFN-beta, IFN-gamma) in THP-1 macrophage cells. The protein inhibits NF-kappa-B ...

... . Centola et al (2000) have identified the gene as an IFN-gamma immediate-early response gene. Tidow et al (2000) have ...

... reduces QRFP expression in macrophages and adipocytes. IFN-gamma downregulates QRFP expression in macrophages only. Both ...

... by TNF-alpha and IL1-alpha (see: IL1) but not by TGF-beta, IFN-gamma and IL6. RANTES is produced by circulating T-cells and T- ...

... RAW264.7: a murine macrophage-like cell line. An assay for IFN-gamma, which measures the concentration of nitric oxide ( ...

... culture medium) generated by RAW264.7 cells stimulated with IFN-gamma has been developed. Following the incubation of cells with ...

... murine IFN-gamma, NO production is found to be linear at IFN-gamma concentrations between 0 and 10 U/mL and logarithmically ...

... under hypoxic conditions or after cell activation with IFN-gamma and bacterial lipopolysaccharides. IFN-alpha, IFN-beta, ...

... NO2-, NO3- or NO2- plus NO3- do not interfere with the IFN-gamma induced NO formation or nitrite measurement. Jenkins et al ...

... . Strong specific cytotoxic T-cell activity and enhanced IFN-gamma and IL2 productions is induced in mice that receive RCAS1 ...

... induces cell death by apoptosis of T-cells and inhibits IFN-gamma production by T-cells when they are cocultured with 4T1 ...

... and chemoattraction-related genes, including IL10 receptor, IFN-gamma, granzyme A, granzyme B and chemokine receptor CXCR3 ...

... , TNF-alpha (see also: TNF-BF, TNF blocking factor) CNTF, IFN-gamma, VEGF, growth hormone, transferrin. The presence of such ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... , Fi-IFN, F-IFN, IFF) (Karube et al, 2006) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Fiumara ...

... et al, 2001; Naumovski et al, 1989) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... Hinz et al, 2002) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... with hyperactive T-cells, with increased production of IFN-gamma and elevated serum levels of Ig and autoantibodies. However ...

... (bright) NK-cells produce significantly greater levels of IFN-gamma, TNF-beta, GM-CSF, IL10, and IL13 in response to monokine ...

... from T-cells costimulates CD56(bright) NK-cells to secrete IFN-gamma. Laroni et al (2011) have reported that the heterodimeric ...

... dim) NK-cells. IL27 treatment results in increased IL10 and IFN-gamma expression, increases viability, and decreases the ...

... ], but as non-regulatory, cytokine-secreting (IL2, IL17, IFN-gamma), activated T-cells a more appropriate term appears to be ...

... human T-cells into Th1 like effectors. and enhances IFN-gamma production by established human T-cell clones. Therefore, ...

... infection. RELM-beta augments CD4(+) T-cell production of IFN-gamma and intestinal inflammation induced by helminth Trichuris ...

... the production of IL23 and IL6 in the lung and raising IFN-gamma levels in the lung. Jo et al (2016) have reported that ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... , 1994; Kumar et al, 2004; Qiao et al, 2001) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... specific genes. Mukhopadhyay et al (2008) have shown that IFN-gamma activates a kinase cascade in which DAPK1 [death-associated ...

... in human monocytic U937 cells after activation with IFN-gamma (Mazumder et al, 2003; Vyas et al, 2009; Kapasi et al, 2007 ...

... cells have been shown to express RIG-I in response to IFN-gamma (Imaizumi et al, 2004). RIG-I plays a role during innate ...

... both type 1 interferon (IFN-alpha) and type 2 interferon (IFN-gamma) (Nanda and Baron, 2006). For other relevant entries see ...

... both type 1 interferon (IFN-alpha) and type 2 interferon (IFN-gamma) (Nanda and Baron, 2006). For other relevant entries see ...

... cell morphology is found also in a cell type described as IFN-gamma-producing immature myeloid cells (gamma-IMCs). For related ...

... not induced by IL2, IL4, IL6, IL9, IL11, IL15, TNF-alpha, IFN-gamma, and bacterial lipopolysaccharides either alone or in ...

... . Combinations of IL1-beta (100 pM), TNF-alpha (100 pM) and IFN-gamma (100 pM) reduce cell viability. Pretreatment of RINm5F ...

... cells. Th1 cells and also NK-cells show reduced levels of IFN-gamma production in response to IL12 and/or IL18. Knock-out ...

... is constitutive but can be induced further by IL1-beta, IFN-gamma, and bacterial challenge. RNASE7 has been shown to ...

... promotes homotypic T-cell aggregation and augmentation of IFN-gamma production. RNASET2 has been implicated also in the ...

... the expression of which can be induced by IFN-alpha, IFN-gamma, and synthetic dsRNA. RNF114 over-expression enhances NF- ...

... production and decreases the numbers of Th1 cells producing IFN-gamma in the colon. Dendritic cells isolated from the colon of ...

... the ability to differentiate naïve CD4(+) T-cells to IFN-gamma producing CD4(+) Th1 cells. In vitro, Wnt-5a - ROR2 ...

... cytokines, including TNF-alpha, IL1-alpha, IL6, IFN-gamma, and GM-CSF in an experimental colitis mouse model. The ...

... proliferation and also decreases the generatil of IL6 and IFN-gamma, without affecting IL2 production. Jin Y et al (2003) have ...

... enhances rather than decreases the secretion of IL2 and IFN-gamma by T-cells stimulated with a combination of antibodies ...

... is similarly susceptible to immune-specific suppression by IFN-gamma and IL4 and by IL27. Role in angiogenesis, ...

... in human rheumatic synovial fluids, induce the secretion of IFN-gamma by human CD4(+) T-lymphocytes. Migita et al (1998) have ...

... host CD4(+) T-cell expression of the signature Th1 cytokine IFN-gamma and simultaneously increases expression of IL4. For other ...

... to a phenotype of M2 macrophages. The expression of IFN-gamma and TNF-alpha is inhibited, while the expression of ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... 2, IFN-alphaR2, IFNABR) (Bilbe et al, 1996) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ; Cherel et al, 1995) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... downregulation of T-cell replication in response to IFN-gamma and IFN-alpha. Sarcolectin has affinity for negatively ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... A member 2b) (Guerreiro et al, 2013) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... by bacterial lipopolysaccharides and IL1, IL2, IL6 while IFN-gamma decreases the expression of SCI. SCI is an inhibitor of ...

... gene expressed in response to IFN-alpha, IFN-beta, and IFN-gamma. LPS negatively regulates the expression of SECTM1 in ...

... of SECTM1 in thymic epithelial cells is upregulated by IFN-gamma. The human genome contains only SECTM1. The mouse genome ...

... that micromolar amounts of SV-IV induce the expression of IFN-gamma, TNF-alpha, IL6, and GM-CSF from human resting peripheral ...

... , IL4). Upon T-cell receptor stimulation, the cells secrete IFN-gamma, abundant atypical pro-inflammatory cytokines such as ...

... of endotoxin shock, which is paralleled with modulated IFN-gamma, IL10 and coagulation responses. For other proteins/ ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... , IFF) (Dejucq et al, 1995; Wu et al, 2008) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... forms of FAS, IGF-1, IGF-2, PDGF, IL2, IL3, IL4, IL5, IL6, IFN-gamma, erythropoietin, colony stimulating factors, and kit ligand ...

... , IL5, IL6, IL7, GM-CSF, TNF-alpha, TNF-beta, ADF, EGF, and IFN-gamma. Abrams et al (1999) have demonstrated that the SAF ...

... ;zary syndrome, and a switch from a Th1 cytokine (IL2 and IFN-gamma) to a Th2 cytokine (IL4) production profile occurs (Rook et ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... protein) (Akilov et al, 2012; Marzec et al, 2008) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Yagi et ...

... al, 1996) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... three days. The cells increase IL8, IL1-alpha, IL1-beta, IFN-gamma, NKEF protein production in response to viral hemorrhagic ...

... disease symptoms, which is associated with impaired IFN-gamma and IL17 production and specific T-cell proliferation. For ...

... freshly isolated rat macrophages. The cytokines IFN-beta, IFN-gamma, IL4, and LPS, although unable to induce SIGLEC-1 ...

... in the pathogenesis of collagen-induced arthritis, such as IFN-gamma, TNF-alpha, IL6, IL17, and IL22 and up-regulation of the ...

... 2, IFN-alphaR2, IFNABR) (Deshmukh et al, 2015) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Schmidt ...

... et al, 2008; Peterson and Pizza, 2009) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... 2002; Ge and You, 2008) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) ( ...

... production. Strong upregulation of the expression of IFN-gamma is seen also in Th2 cells, whereas IL4 or IL5 expression is ...

... of NTB-A enhances NK-cell activity and synthesis of IFN-gamma and contributes to the inability of NK-cells to kill ...

... cytotoxic activity and, in cooperation with neutrophils, IFN-gamma production by NK-cells (Schäkel K et al, 1998; Schmitz ...

... protein is produced by macrophages (Jin et al, 1997), and IFN-gamma suppresses its expression. Jacobsen et al (2008) have ...

... cytokines, including TNF-alpha, IL6, IL17, IL1-beta, IFN-gamma and MCP-1 (Zhang et al, 2018). Copyright © 1997-2021 ...

... B mRNA expression is regulated by retinoic acid, EGF and IFN-gamma (Mastrangeli et al, 2003). ARS Component B gene mutations ...

... caspase-3. Yoshikawa et al (2001) have demonstrated that IFN-gamma induces cell death by apoptosis in WEHI 279 mouse B-cells ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... 2, IFN-alphaR2, IFNABR) (Chevillard G et al, 2007) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Gerdes et ...

... al, 2002) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... C) (Chang et al, 2011) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... et al, 2002) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... (1999) have reported that SOCS1 is a critical inhibitor of IFN-gamma signaling and prevents the potentially fatal neonatal ...

... to kill Leishmania major parasites, which depends on IFN-gamma. Administration of antibodies directed against IFN-gamma ...

... of colorectal carcinoma. Treatment with antibodies against IFN-gamma can prevent tumor development. Yasukawa et al (2003) have ...

... also inhibits other immune responses, including IFN-gamma secretion (which affects IgG2a production in murine ...

... include aFGF, BDNF, EGF, G-CSF, GDNF, GM-CSF, IFN-alpha, IFN-gamma, IGF-1, IL10, IL13, IL15, IL18, IL1-alpha, IL1-beta, IL1ra ...

... genes that regulate sensitization to cell death induced by IFN-gamma in neuroblastoma cells. Sequence analysis shows that SOXN ...

... SOXN expression confers resistance to apoptosis induced by IFN-gamma, but has no effect on suppression of cell growth induced by ...

... IFN-gamma. Ectopic overexpression of SOXN sensitizes cells to induced ...

... SP stimulates the synthesis of IL1, IL6 and TNF-alpha and IFN-gamma in monocytes and cultured lymphocytes and could therefore ...

... in increased macrophage production of IL10, IL12, and IFN-gamma and reduced goblet cell hyperplasia. Olde Nordkamp et ...

... ST2L is co-expressed with intracellular IL4, but not with IFN-gamma. An antibody against a peptide derived from ST2L ...

... . In vivo, it enhances Th1 cell responses by increasing IFN-gamma production and decreasing IL4 and IL5 synthesis. It induces ...

... addition to its central role in the IFN-alpha, IFN-beta and IFN-gamma responses also appears to be activated by IL10, the CNTF ...

... human neutrophils and also reverses the negative effects of IFN-gamma on IL8 production. IL2-driven mitogenesis in IL2 dependent ...

... by concanavalin A. STIF is not identical with IL2 or IFN-gamma. It inhibits the DNA synthesis of mouse bone marrow and ...

... lacking either STIM1 or STIM2 produce less cytokines (IL2, IFN-gamma, IL4) in response to T-cell receptor stimulation owing to ...

... cells. STIM1 knock-out T-cells exhibit markedly reduced IFN-gamma production during the early phase of infection, but ...

... . During the chronic phase, these T-cells display enhanced IFN-gamma production in response to elevated levels of IL12 and IL18 ...

... STIM1 in iTreg differentiation and excessive production of IFN-gamma and IL12, which suppress differentiation and maintenance of ...

... responses but that neutrophil cytokine (TNF-alpha IL10, and IFN-gamma) production requires STIM2, but not STIM1, at least in part ...

... responses but that neutrophil cytokine (TNF-alpha IL10, and IFN-gamma) production requires STIM2, but not STIM1, at least in part ...

... signalling in response to the pro-inflammatory cytokine IFN-gamma. Cheung et al (2003) have identified a 34 kDa ...

... neu oncogene (Kalra J et al, 2010); inhibition of hsp70 by IFN-gamma and TNF-alpha under conditions of stress (Hu et al, 2010), ...

... of IFN-alpha and IFN-beta. Suppressin also potentiates IFN-gamma augmentation of NK-cell activity. In vivo, Suppressin ...

... is seen with NK-cells (reduced expression of TNF-alpha, IFN-gamma), T-cells (reduced IFN-gamma production by CD8(+) T-cells; ...

... . Factors possessing suppressor activity include IFN-gamma and IFN-alpha, and a number of biochemically ...

... -O-tetradecanoyl-phorbol-13-acetate (Park et al, 2002) and IFN-gamma (Hubackova et al, 2019). Aoshima M et al (2019) have ...

... this production is upregulated significantly by TNF-alpha. IFN-gamma only upregulates production of endothelin-1 and treatment ...

... capacity on CD3 activated T-cells for proliferation, IFN-gamma and TNF-alpha production. Copyright © 1997-2021. All ...

... ). Th1 cytokines such as IL1-beta or TNF-alpha (but not IFN-gamma or Th2 cytokines such as IL4 or IL13) induce shedding in ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... , Fi-IFN, F-IFN, IFF) (Brentano et al, 2005) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... SY and Kim HY, 2005) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) (Moller ...

... et al, 2003) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... with TNF the activity of which is also potentiated by IFN-gamma. TNF mainly acts on endothelial cells and increases their ...

... and decreasing the secretion of pro-inflammatory IFN-gamma in response to LPS. The peptides are thought to inhibit ...

... , enhance the mitogen induced release of cytokines such as IFN-gamma, TNF-alpha, IL1 and IL6 by granulocytes and macrophages, ...

... enhanced significantly by addition of either IL4, IL6, or IFN-gamma. For an overview of other cell lines used in research on ...

... infected with Tanapoxvirus. The protein binds to human IFN-gamma, IL2 and IL5 and inhibits their bioactivity (viral IFN- ...

... Tanapoxvirus IFN-gamma/IL2/IL5 binding protein: see: Tanapoxvirus 38 kDa protein ...

... these macrophages with Phorbol 12-myristate 13-acetate or IFN-gamma enhances superoxide formation in peritoneal macrophages. ...

... in response to stimulation with lipopolysaccharide and IFN-gamma is also increased. The secretion of the pro-inflammatory ...

... with LPS, with or without addition of either TNF-alpha or IFN-gamma. In vivo, knock-out mice devoid of Tartrate-resistant acid ...

... anti-CD3, T-cells from these knock-out mice produce less IFN-gamma, but there is no difference in IL4 production. These knock- ...

... lymphocytes reactions, inducing a concomitant increase in IFN-gamma production by T-cells. Secretion of IL10, an antagonist of ...

... and activity of these receptors can be upregulated by IFN-gamma. Through this mechanism tat protein can mediate vascular ...

... the expression of some integrins. IL1-beta, TNF-alpha, and IFN-gamma, synergize with tat to promote in nude mice the development ...

... pattern of secreted factors and express both IL4 and IFN-gamma (Vukmanovic-Stejic et al, 2000). For other subpopulations ...

... of secreted factors. Like Th1 cells, Tc1 cells secrete IFN-gamma but no IL4, which distinguishes them from another ...

... . Like Th2 cells, Tc2 cells secrete IL4 but don't produce IFN-gamma, which distinguishes them from another subpopulation, Tc1 ...

... into transient IL9 producers characterized by specific IFN-gamma and IL10 expression patterns as well as by low cytotoxic ...

... CCR6 and a high level of CCR5. Most Tc17 cells produce IFN-gamma, but a small fraction of these cells are IFN-gamma negative ...

... cells (T-box transcription factor Eomesodermin, granzyme B, IFN-gamma). These cells express hallmark molecules of the Th17 cell ...

... are mainly double-producing cells that secrete IL17 and IFN-gamma and have been termed Tc17/IFN-gamma cells. These converted ...

... the conversion of mouse Tc17 cells producing IL17 to Tc17/IFN-gamma cells that produce IL17 and IFN-gamma. This conversion is ...

... expand 20-fold and a majority secretes IL17, but little IFN-gamma. Many of the IL17 secreting cells also secrete TNF-alpha, ...

... their ability to produce IL17, but a subset secretes IFN-gamma or both IFN-gamma and IL17. After adoptive cell transfer ...

... . Unlike most circulating Tc17 cells, which do not express IFN-gamma, >80 % of Tc17 cells in tumor tissues express IFN-gamma. ...

... Tc17 cells that express IFN-gamma have significantly higher expression of pro-inflammatory ...

... Tc17/IFN-gamma cells: [Tc17/IFN-gamma cell] see: Tc17 cells. For related information of ...

... T-cells that produce IL22 but lack expression of IL17A and IFN-gamma. Res et al (2010) have suggested a relationship between ...

... induces the production of IL17. Both IL15 and IL2 induce IFN-gamma production but do not induce differentiation of Tc22 cells ...

... gene has been deleted by targeted disruption do not produce IFN-gamma, which is one of the characteristic features of Th1 T- ...

... distinguishable from IL1, IL2, IL3, IL4, IL5, IL6, IFN-gamma, and TNF-alpha. The factor is also not identical with GM- ...

... have TRF activities (for example, a combination of IL2, IFN-gamma, and TNF-alpha). Factors present in the conditioned medium ...

... in humans. In humans IL2 possesses TRF activity. Likewise, IFN-gamma functions as a TRF in mice but not in humans. Even simple ...

... . RA-SF is biologically distinct from IL2, IL4, IL5 or IFN-gamma. It has been observed that concanavalin A, used frequently ...

... activity may be identical with murine (but not human) IFN-gamma (Brunswick and Lake, 1985). See also: TRF-2 [T-cell ...

... that most Gamma-Delta T-cells express CD27 and secrete IFN-gamma, whereas IL17 production is restricted to CD27(-) Gamma- ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... receptor 2, IFN-alphaR2, IFNABR) (Rep et al, 1996) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Ausiello ...

... ; Wright et al, 2007) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... et al, 2009) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... synthesis by Th1 T-helper cells and natural killer cells of IFN-gamma in combination with IL2. Production of IFN-gamma is ...

... or a mixture of soluble factors. TDRF synergizes with IFN-gamma and bacterial lipopolysaccharides, IL2, or TNF-alpha to ...

... induce specific cytotoxic T-cells that can secrete IFN-gamma and lyse hepatocellular carcinoma cells. Furthermore, the ...

... differentiated effector cells as judged by low IL2 and high IFN-gamma secretion (Sallusto et al, 1999), high cytotoxicity (Hamann ...

... cells proliferate poorly and lose the ability to produce IFN-gamma over time after TCR stimulation. TEMRA cells show impaired ...

... which induces a unique transcriptional signature, promotes IFN-gamma production and cell cycle entry, and reduces chemotaxis ...

... telomeres and show significantly more BrdU uptake and IFN-gamma release upon stimulation compared to the CD57(+) ...

... higher CMV peptide sensitivity in BrdU uptake and IFN-gamma release assays compared to CD57(+) TEMRA cells, but CD57 ...

... significantly inhibits stimulus-induced proliferation and IFN-gamma and TNF-alpha production in human peripheral blood ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... IFF) Bhushan et al, 2008; Dejucq et al, 1995 •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... ;nkorva et al, 2002) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) (Abu ...

... antibodies against TGF-beta. Cytokines such as IFN-beta, IFN-gamma, and TNF-alpha have been shown to be approximately 100-fold ...

... . This induction is enhanced further in the presence of IFN-gamma. Yang et al (2018) have reported that the release of ...

... the expression of MHC class 2 antigens induced by IFN-gamma and the production of IL1, IL6, and TNF-alpha by these ...

... and inhibits the synthesis of TNF-alpha, TNF-beta and IFN-gamma in adherent human monocytes and murine macrophages. TGF- ...

... considered a subpopulation of Th1 cells that produce both IFN-gamma and IL17 and, therefore, also resemble Th17 cells (Mangan ...

... of IL17A than classical Th17 cells but high levels of IFN-gamma (Annunziato et al, 2012). It is thought that these cells ...

... a subset of Th1-like Th17 cells expressing high levels of IFN-gamma, GM-CSF, very late antigen 4 (VLA-4; CD49d / CD29), and low ...

... augments Th9 differentiation, whereas the Th1 cytokines IFN-gamma and IL27 partially suppress IL9 production (Murugaiyan et ...

... also favours Th9 cell induction (Xiao et al, 2012). IFN-gamma limits autoimmune inflammation mediated by Th9 cells ...

... SEA challenge with impaired production of IL2 , TNF-alpha, IFN-gamma, and IL4. The IL10 production is sustained after a third ...

... and a fourth SEA challenge in the complete absence of IL2, IFN-gamma, and IL4. Pretreatment of mice with neutralizing anti-lL10 ...

... mAb before the SEA challenges substantially enhances IFN-gamma and TNF-alpha serum levels, but fails to rescue IL2 ...

... effector molecules of Th1 cells and Th2 cells such as IFN-gamma and IL4, have each been found to negatively regulate the ...

... dendritic cells are polyfunctional and co-express IL17 and IFN-gamma. These cells have been termed Th17-1 cells [Th17-1 helper ...

... subpopulation of Th17 cells that express not only IL17 and IFN-gamma, but also GM-CSF and IL22. These cells may be CCR6(+) CCR4 ...

... from patients with Crohn's disease readily produce IL17 and IFN-gamma upon stimulation with IL23. Yu et al (2009) have reported ...

... by the secretion of IL22 and TNF-alpha, but not IFN-gamma, IL4, or IL17 (Eyerich et al, 2009). These cells have been ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... as Th1 cytokines or Type 1 cytokines and including IL2, IFN-gamma, IL12 and TNF-beta. Immune responses in which Th1 cells and ...

... of IL17. Th1 cells, but not Th2 cells, secrete IL2, IFN-gamma, and TNF-beta, whereas Th2 cells, but not Th1 cells, ...

... as IL13. A novel cytokine inducing the synthesis of IFN-gamma in Th1 cells has been identified recently as IGIF (and ...

... each other by the cytokines they secrete. For example, IFN-gamma, secreted by Th1 cells, can inhibit the proliferation of ...

... histiocytic lymphoma differentiated and growth-arrested by IFN-gamma restores the cells to a highly proliferative state. ...

... factor in keratinocytes has been shown to be decreased by IFN-gamma. A combination of IFN-gamma and TNF-alpha inhibits ...

... suppresses the production of the pro-inflammatory cytokines IFN-gamma and TNF-alpha, and induces the depletion of tissue-residing ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... 2, IFN-alphaR2, IFNABR) (Cufi P et al, 2014) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... T) (Cui G et al, 2014) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... cytokines) induces thymic epithelial cell proliferation and IFN-gamma and TNF-alpha enhance the effects of IL1. Thymic epithelial ...

... also enhances IL2 production, IL2 receptor expression, and IFN-gamma production in mitogen-stimulated large granular lymphocytes ...

... and has been shown to enhance the production of IL2 and IFN-gamma in cord blood lymphocytes. A study of immunocompromised ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... , 1990; You et al, 1999; Selzer et al, 1994) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... appear to regulate the production of IL1-beta, GM-CSF, or IFN-gamma, indicating that its effects are, at least partially, ...

... interact with the signal transducer JAK2 and with the human IFN-gamma receptor subunit R2 and can modulate transcriptional ...

... activity mediated by IFN-gamma. Trentin et al (2001) have reported that murine TID1 binds ...

... and hemolytic activities but inhibit production of IFN-gamma by peritoneal cells from C57BL/6 mice without affecting ...

... , tigerinin-1M and tigerinin-1V suppress the production of IFN-gamma with no effect on IL17 production, and also enhance IL10 ...

... c) with inhibition of cytokine production, predominantly IFN-gamma. Knock-down of TIGIT expression increases both T-bet and ...

... IFN-gamma expression with concomitant decrease in IL10 expression. ...

... down-regulates the expressions of IL6, IL8, IL12, IL15, IFN-gamma, cathepsin G, caspase-7, and BCL2, and upregulates IL2 and ...

... and greatly enhanced synthesis of IL4 (but not IFN-gamma) in Th2 cells. In vivo, Tim-1 antibody plus antigen ...

... treatment substantially increases the production of IL4 and IFN-gamma in unpolarized T-cells, prevents the development of ...

... with hyperactive T-cells, with increased production of IFN-gamma and elevated serum levels of Ig and autoantibodies. However ...

... . They are unable to secrete effector cytokines, such as IFN-gamma and TNF-alpha (Jones et al, 2008; Golden-Mason et al, 2009 ...

... by Th1 cells and Th17 cells because the secretion of IFN-gamma, IL2, IL17 and IL6 by human CD4(+) T-cells is increased in ...

... through CD3 and CD28 and the production of IL2 and IFN-gamma in vitro. In a tumor rejection model, soluble Tim-3 ...

... as a human NK-cell co-receptor to enhance production of IFN-gamma in response to the Tim-3 ligand galectin-9. Antibody ...

... blockade of Tim-3 significantly decreases IFN-gamma production. HBV infection can up-regulate Tim-3 expression ...

... PDCD1 and Tim-3 are deficient in their ability to produce IFN-gamma, TNF-alpha, and IL2 in response to PDCD1 ligand (PDL1) and ...

... defined by failure to proliferate and produce IL2, TNF, and IFN-gamma. • hepatocellular carcinoma: Li H et al(2012) ...

... T interferon: An alternative older name for IFN-gamma. Copyright © 1997-2021. All rights reserved by Dr H ...

... cells have been primed previously for tumor cell killing by IFN-gamma (Fletcher et al, 1992; Kujubu et al, 1991). TIS11 [TPA ...

... of TL1A is inducible by TNF and IL1-alpha but not by IFN-gamma. TL1 is expressed in various tissues but at high levels in ...

... in response to IL2. It also induces secretion of IFN-gamma and GM-CSF. Treatment of mice with TL1A strongly enhances ...

... jejuni. Cytokine responses to the two pathogens (IL6, IFN-gamma, IL8, K60) also differ. Michailidis et al (2010 have ...

... of primary head kidney cells with IFN-alpha, IFN-beta, or IFN-gamma or IL1-beta does not seem to affect receptor expression. ...

... mammalian TLTF-like gene has been identified as gas-11. IFN-gamma induces the production of TLTF in CD8(+) T-cells infected ...

... with the parasite and TLTF induces the production of IFN-gamma, which in turn stimulates parasite growth (Hamadien et al, ...

... for human first trimester forebrain cells and induces IFN-gamma production, with astrocytes being the major producers of ...

... IFN-gamma. IFN-gamma is produced also by rat dorsal root ganglia in response to ...

... production. This activity is enhanced in the presence of IFN-gamma (Kim et al, 2003). Choi et al (2003) have reported that ...

... proliferative and rapidly secrete multiple cytokines (IFN-gamma, Granzyme B, IL1-beta, CXCL3, but not IL22, in response to ...

... TGF-beta, soluble immune-response suppressor (see: SIRS), IFN-gamma, or JE. Copyright © 1997-2021. All rights reserved by ...

... non-cytotoxic, produce IL17, and do not produce granzyme B, IFN-gamma, or IL10. Others have referred to these cells as Tc17 cells ...

... receptor density is induced by IFN-alpha, IFN-beta, and IFN-gamma. For signal transducers that associate with the ...

... angiogenic activity of TNF is significantly inhibited by IFN-gamma. TNF-alpha is a growth factor for normal human diploid ...

... production of IL1, colony stimulating factors (see: CSF), IFN-gamma, arachidonic acid metabolism. It also stimulates the ...

... with either TNF-alpha or TNF-beta. IFN-alpha, IFN-beta, IFN-gamma, TGF-beta, IL4, LIF and GM-CSF have been shown not to ...

... TNF and cytotoxic or immune modulatory agents, particularly IFN-gamma and possibly IL2, may be of advantage in the treatment of ...

... are modulated by crude LPS, peptidoglycan, poly(I:C), and IFN-gamma in cell lines and primary macrophages, as well as by ...

... -alpha synergism with HLA-DR antigen expression induced by IFN-gamma but has no effect on IFN-gamma activity. The NH2-terminal ...

... with either TNF-alpha or TNF-beta. IFN-alpha, IFN-beta, IFN-gamma, TGF-beta, IL4, LIF and GM-CSF have been shown not to ...

... T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2. Activation of T-cells in the absence ...

... on murine CD4(+) T-helper cells and T-cells is inhibited by IFN-gamma. It is inhibited by TGF-beta only on T-helper type 2 cells ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... -inducible protein 1-8U) (Rozsa et al, 2006) • IFN-gamma receptor 2 (interferon-gamma transducer-1) (Luna et al, ...

... , IL18BPb, IL18BPc, IL18BPd, IGIFBP, IGIF binding protein, IFN-gamma inducing factor binding protein, Tadekinig-alpha) (Porter ...

... with its receptor. Takayanagi et al (2000) have shown that IFN-gamma strongly suppresses osteoclastogenesis by interfering with ...

... . Expression is upregulated by LPS and downregulated by IFN-gamma. Chen et al (2008) have reported expression of TREM2 on ...

... B7-H3 preferentially up-regulates the proliferation and IFN-gamma production of CD8(+) T-cells. Transduction of REML2 into T- ...

... cells results in enhanced IL2 and IFN-gamma production via interactions with B7-H3. Blockade of the ...

... of the receptor on cytokine and chemokine production (IL8, IFN-gamma, CCLe (MIP-1-alpha)), whereas its silencing reverses the ...

... enhanced IL12-p40 expression in macrophages stimulated by IFN-gamma / TLR receptor engagement in an IRF8-dependent manner (Kong ...

... -alpha and IFN-beta are the most potent inducers of TRIM21. IFN-gamma also induces TRIM21 expression. IRF1 and IRF2 strongly ...

... Sjögren's syndrome compared with healthy controls. IFN-gamma induces TRIM21 indirectly via IRF1 and not directly via ...

... ), IER3 [immediate-early response-3] (Lai et al, 2006) IFN-gamma (Ogilvie et al, 2009), IL1-beta (Chen et al, 2006; Bros et ...

... Stoecklin et al, 2004). Sauer et al (2006) have shown that IFN-gamma and IFN-beta induce expression of TTP in macrophages. This ...

... class 2 and downregulates MHC class 2 expression induced by IFN-gamma in mouse cerebrovascular endothelial cells. Trophoblast ...

... seem to affect levels of IL10, it promotes enhanced IL4 and IFN-gamma responses by effector T-cells (Tuo et al, 1999). ...

... receptor, ICAM-1, intercellular adhesion molecule 1, IFN-gamma regulated human melanoma-associated antigen, Ly47, MALA-2, ...

... receptor 2, IFN-alphaR2, IFNABR) (Hunt et al, 1990) • IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) (Bulmer et ...

... al, 1990) •• IFN-gamma (IFNG, interferon-gamma, Gamma-Interferon, gIFN) receptors ...

... (IFNGR1, IFN-gamma receptor-1, IFN-gamma-R1, interferon-gamma receptor 1, immune interferon receptor ...

... protein type 2, CD119, IFNGR2, interferon-gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, IFGR2, IFNGT1, interferon-gamma ...

... S et al, 2007) • IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... et al, 2015) •• IL18 (interleukin-18, IGIF, IFN-gamma inducing factor, IL1-gamma, IL1F4, IL1 family member 4, ...

... blood mononuclear cells from chagasic individuals produce IFN-gamma but only minimal amounts of IL4 or IL10 on stimulation with ...

... protein 53 kDa], the expression of which is induced by IFN-gamma. The protein shows significant sequence homology to rabbit ...

... tRNA. The gene has been identified independently as IFN-gamma-inducible protein gamma-2. IGUP 1-3524 [interferon-gamma ...

... of DNA-dependent protein kinase in a manner dependent on IFN-gamma and this process ultimately leads to the phosphorylation ...

... Role in angiogenesis The anti-proliferative cytokine IFN-gamma has been shown to be a strong inducer of mini-TrpRS ...

... the infection. Jobin et al (2019) have reported that IFN-gamma induces the secretion of Tryptophanyl-tRNA synthetase from ...

... in bone marrow-derived dendritic cells induced by IFN-gamma, thereby regulating CD8(+) T-cell polarization. Wang et ...

... cord blood-derived mesenchymal stem cells in response to IFN-gamma. This plays a suppressive role in limiting excessive ...

... (mouse fibroblast L929) cells upon treatment with IFN-gamma, resulting in their sensitization to virus infection. ...

... uncharacterized factor is not identical with IL2, IL3, IFN-gamma, or IL1. It is a protein of approximately 14.5 kDa that ...

... cycle. Cell growth is suppressed also by IFN-alpha and IFN-gamma, causing cell cycle arrest. IFN-gamma also increases cell ...

... potent cytolytic activity and the ability to produce IFN-gamma in addition to IL5 and IL13 in response to CD40 ligand. ...

... ] have been show to increasee levels of the Th1 cytokine (IFN-gamma), to increase T-cell cytotoxicity, and to decrease worm ...

... combination of suboptimal concentrations of this factor and IFN-gamma also inhibit the growth of these cells. The activity of ...

... . The cytotoxic activities of TILs are enhanced by IFN-gamma. The antitumor activity of TILs in vivo is blocked by TGF- ...

... defects in the ability to activate degranulation and IFN-gamma production. Platonova et al (2011) have reported also that ...

... the human adenocarcinoma cell line HT29 in the presence of IFN-gamma (Chicheportiche et al, 1997) and appears to control ...

... ] this designation refers to cytokines such as IL2 and IFN-gamma produced by Th1 T-helper cells. Note: don't confuse with ...

... abbr. sometimes IFN-II. This interferon is identical with IFN-gamma. See also: IFN for general information about interferons. ...

... (Key et al, 1988). However, the cells respond to IFN-gamma with rapid accumulation of HLA class 2 mRNA and de novo ...

... produced constitutively and IL1-beta, IL6, IL8, TNF-alpha, IFN-gamma, and MIP-1-alpha are upregulated upon stimulation. The ...

... and IL2, PDGF, aFGF, bFGF, EGF, G-CSF, IL3, IL5, IL6, IFN-gamma, TNF-alpha and IL1ra itself have no effect. The cells also ...

... production of TGF-beta. Zella et al (1998) have shown that IFN-gamma increases the expression of chemokine receptors CCR1, CCR3 ...

... D3, IL6 (see: DIF, differentiation inducing factor), IFN-gamma, and TNF-alpha induce the differentiation of U937 cells ...

... cells resembling monocytes and macrophages secreting M-CSF. IFN-gamma also upregulates the expression of TRAIL, and the cells ...

... by U937 cells if the cells are activated by treatment with IFN-gamma, which induces the production of nuclear receptors for ...

... is a strong inducer of IL8 expression in U937 cells. IFN-gamma enhances thrombin induced IL8 production and prostaglandin ...

... E2 acts as a negative regulator. TNF-alpha and IFN-gamma increase the amount of cellular mRNA for H-Ferritin, but ...

... factor for monocytes of 45-55 kDa, distinct from IFN-gamma, TNF-alpha, or GM-CSF, produced by CD4(+) CD8(+) T-cells ...

... RAW264.7 cells (derived from macrophages) activated with IFN-gamma. The sequence of the first 16 amino acids of Ubiquicidin ( ...

... response, i.e., producing abundant CCL2, IL6, TNF-alpha and IFN-gamma. The protective role mediated by UNC93B1 to T. gondii ...

... is associated with impaired IL12 responses and delayed IFN-gamma production by spleen cells. In macrophages infected with T ...

... -2 in response to treatment with lipopolysaccharides or IFN-gamma. For other entries pertaining to cell death mechanisms see ...

... affinity for IL8, and low binding affinity for IL6 and IFN-gamma. They suggest that the intact protein core structure rather ...

... cytokines such as IL1-beta, TNF-alpha, and Th1 cytokine IFN-gamma, whereas Uromodulin only induces IL1-beta and suppresses ...

... both Th1 cytokine IFN-gamma and Th2 cytokine IL10 (Hong CY et al, 2015). Darisipudi et ...

... with the wild-type virus. In addition, levels of IL12 and IFN-gamma are higher than those found in wild-type-infected animals ...

... inflammatory activity by interfering with the activities of IFN-gamma. It inhibits production of IFN-gamma by stimulated human ...

... cells and also diminishes the biologic activity of IFN-gamma (antiviral activity, stimulation of phagocytosis). Hay et ...

... eotaxin, but not RANTES, were also seen, whereas levels of IFN-gamma were comparable to levels observed in wild-type mice. The ...

... -kappa-B increases CD8(+) memory T-cell function, with more IFN-gamma production and greater protection against virus infection ...

... . Najarro et al (2001) have reported that VH1 blocks IFN-gamma signal transduction (JAK-STAT pathway) by dephosphorylating ...

... presence of IFN-alpha. The mutant is not hypersensitive to IFN-gamma. IFN-alpha stimulates gene products that can phosphorylate ...

... by acting on the type 2 VEGF receptor. TNF-alpha, IL1 and IFN-gamma decrease VEGF-stimulated vasohibin expression. Yamashita ...

... ). AVP also plays an important role in the regulation of IFN-gamma production by providing a helper signal (induction of IL2 ...

... given in newer publications to the Myxoma virus-encoded IFN-gamma receptor MT-7. See also: viroceptor. For other entries ...

... breast cancer cells correspond with low VCAM-1, ICAM-1, and IFN-gamma in the tumors. When expressed by tumor cells, VE-statin ...

... peripheral sites where they secrete Th1 cytokines such as IFN-gamma and TNF-alpha, inflammatory chemokines, and growth factors ...

... to as E19) blocks NF-kappa-B activation and induction of IFN-gamma in response to IL18 (Smith et al, 2000). The vaccinia virus ...

... . VIP has been shown to inhibit the generation of IL2 and IFN-gamma from mitogen-stimulated human and murine lymphocytes. ...

... . Its expression is induced by IFN-alpha, IFN-beta, and IFN-gamma, (Chin and Cresswell, 2001), poly(I:C) (Helbig et al, 2005 ...

... CD30 ligand. The protein blocks the generation of IFN-gamma producing cells in vitro and is a potent inhibitor of T- ...

... cytokines IL1-beta, IL6, IL8, IL12, TNF-alpha, IL10, and IFN-gamma. Antibodies against TLR2 significantly reduce the secretion ...

... downregulation of IFN-alpha receptors, gp130, IL23R, and IFN-gamma receptor. Leang et al (2011) have reported that MHV-68 ...

... viral IFN-gamma/IL2/IL5 binding protein: see: Tanapoxvirus 38 kDa protein ...

... Factor SourceFunction B8R vaccinia virus receptor for IFN-gamma B15R vaccinia virus binding to IL1-beta B18R ...

... of chemokines, RANTES M-T7 Myxoma virus binding to IFN-gamma orf74 Herpesvirus KSHV IL8 receptor p13 ectromelia ...

... Tanapoxvirus 38 kDa protein Tanapoxvirus binding to IFN-gamma, IL2, IL5 T2 Myxoma virus binging to TNF-alpha, TNF- ...

... -inflammatory cytokine genes IL1-beta, IL6, TNF-alpha, and IFN-gamma in the spleen and head kidney of A. hydrophila-infected ...

... is stimulated by TGF-beta and inhibited by TNF-alpha and IFN-gamma. Vitronectin also competes with fibronectin for binding to ...

... two functions of cognate antigen-specific T-cell clones: IFN-gamma production and mobilization of CD107a, a cytolytic granule ...

... construct has been shown to elicit significantly higher IFN-gamma responses upon antigen stimulation of splenocytes from ...

... inhibits signaling downstream of IFN-alpha, IFN-beta, and IFN-gamma by sequestering karyopherin-alpha proteins (Reid et al, ...

... transcriptional responses to IFN-alpha, IFN-beta, and IFN-gamma and also interferes with signaling by IL6 and the non- ...

... that are involved in activating IFN-alpha IFN-beta- and IFN-gamma responsive genes by specifically targeting STAT1 for ...

... and chemokine production by human T-cells including IFN-gamma, IL2, IL17, CCL5, CCL3, and CXCL1. Copyright © 1997- ...

... 1961). This cell line is used to assay human IFN-alpha and IFN-gamma. The interferons (see: IFN) are quantified by performing a ...

... are significantly more sensitive for both IFN-alpha and IFN-gamma when EMCV (encephalomyocarditis virus) is used instead of ...

... enhanced in the presence of mixtures of human interferons. IFN-gamma inhibits the rise in Transferrin receptor mRNA level which ...

... production induced by EGF. Pretreatment of WISH cells with IFN-gamma in the presence of 12-O-tetradecanoyl-phorbol-13-acetate ...

... of Wnt-5a is most highly induced by a combination of LPS andIFN-gamma and suppressed by activated protein C and IL10. A ...

... induced IL12 response of antigen-presenting cells and IFN-gamma production by mycobacterial antigen-stimulated T-cells. ...

... pancreatic cancer. Wnt-14 mRNA expression is upregulated by IFN-gamma, but not by TNF-alpha in MKN45 cells derived from gastric ...

... induces expression of Ym1 (Nair et al, 2003). In vitro, IFN-gamma antagonizes the effect of IL4. Expression of Ym1 by ...

... also by ADF and TNF-alpha. IL2, IFN-alpha, IFN-beta, IFN-gamma, or lectins such as concanavalin A and phytohemagglutinin-P ...

... cause IL2 receptor expression. IL2, IL12 or IL15 but not IFN-gamma induce expression of CD26. For an overview of other cell ...

... ascites tumors. Mouse peritoneal macrophages, stimulated by IFN-gamma or LPS, also express significant amounts of DLM-1. The ...

... recognition receptor. The expression of DAI is inducible by IFN-gamma. The artificial expression of DAI in mouse fibroblasts ...

... MLIF has been shown to inhibit the expression of IL1-beta, IFN-gamma, IL5, and IL6 and to increase the expression of IL10 in ...

... of CCL3, CCL8, and CXCL10. Blocking antibodies to IFN-gamma and TNF-alpha inhibited CCL8 and CXCL10 but not CCL3 ...

... Using these kits, the minimum detectable concentrations of IFN-gamma, IL1-beta, IL2, IL4, IL5, IL6, IL9, IL10, IL12-p70, IL13, ...