A224L |
A375 |
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[African swine fever virus A238L] This protein is encoded by African swine fever virus (ASFV). The protein has been described also as 5EL. The protein shows homology to I-kappa-B, the inhibitor of transcription factor NF-kappa-B.
A238L has been shown to inhibit binding of NF-kappa-B to DNA thus effectively blocking transcription of genes depending upon this transcription factor (Powell et al, 1996; Tait et al, 2000).
ASFV effectively inhibits synthesis of antiviral, pro-inflammatory cytokines IFN-alpha, TNF-alpha, and IL8 in infected macrophages. Levels TGF-beta, one of the anti
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