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Adoptive immunotherapy

abbr. AIT. Name given to a form of therapy in which immune cells are transferred to tumor-bearing hosts. The immune cells have antitumor reactivity and can mediate direct or indirect antitumor effects.

In human patients the treatment protocol involves the intravenous injection of IL2 for several days, followed by leukopheresis (collection of leukocytes), cultivation of isolated leukocytes in vitro in the presence of high concentrations of IL2, and subsequent re-infusion of the leukocytes. This in vitro treatment leads to the proliferation and expansion of a subpopulation of peripheral mononuclear blood cells known as LAK cells ( ... ... ... ...
 
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Entry last modified: April 2002



 
 
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