Viroceptors

A term proposed to describe a virus-encoded homolog of cellular receptors of cytokines (cytokine receptor mimics). These homologous proteins are found in a number of viruses, particularly in members of the poxvirus, herpesvirus and retrovirus families and are thought to derive from captured and modified cellular genes. Some of the factors listed here appear to be proteins unrelated to known cellular proteins.

Most of these receptor homologous proteins are either secreted glycoproteins or are located at the infected cell surface. It is believed that the function of these viral receptor mimics is to intercept the activity of the cognate cytokine, thus effectively short-circuiting host immune responses to the viral infection.

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Entry last modified: March 2019