AGCUS |
age-associated B-cells |
family with sequence similarity 3 member A |
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[advanced glycosylation end product; advanced glycation end product] AGEs are a complex and heterogeneous group of compounds that are obtained as end products of a series of reactions involving the nonenzymatic glycosylation in vivo of cellular proteins, lipoproteins, or nucleic acids.
AGE modifications begin with a condensation reaction between reducing sugars (aldoses) an free amino groups. The initial Schiff base aldimine adduct undergoes rearrangement to a ketoamine, designated
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