AGQAFRKFLPLFDRVLVERS |
AGR3 |
CD141 |
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(approved gene symbol) [Anterior Gradient-2]; also: AG2. The AGR2 protein is a member of the family of protein disulfide isomerases (for overview see Shishkin et al, 2013) and is being referred to in databanks also as PDIA17 [protein disulfide isomerase family A member 17].
AGR2 is highly conserved among vertebrates from amphibians to humans. Mature AGR2 is a small protein of 154 amino acid with a single central Cys residue and a non-conventional endoplasmic reticulum retention motif (KTEL) (Gupta et al, 2012). It is a non-covalent dimer in the endoplasmic reticulum (Patel et al, 2013). Zweitzig et al (2007) and Park et al (2009) have suggested that AGR2 may act as a chaperone
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