Amylin

This protein is known also as islet amyloid polypeptide or insulinoma amyloid polypeptide (abbr. and approved gene symbol: IAPP). The name amylin has been proposed by Cooper et al (1988) for a factor of 37 amino acids (KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYamide) known previously as diabetes-associated peptide (abbr. DAP), isolated from islets of Langerhans amyloid (an abnormal deposit of extracellular protein complexes) in diabetics with type 2 diabetes, and expressed in islet beta-cells of both normal and type 2 diabetic subjects as well as in insulinomas (Cooper et al, 1987). A synonym for Amylin is IAPP(1-37).

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Entry last modified: September 2006