Astacin

The astacin protein family is a family of zinc endopeptidases, characterized by highly conserved regions containing the zinc binding motif, and another conserved region, SxMHY (so-called Met-turn) (Bond and Beynon, 1995). The name is derived from astacin, a digestive enzyme isolated from the freshwater crayfish Astacus astacus. This protein family is member of a larger family named metzincins. Guevara et al (2010) have reported the mechanism by which astacin proenzymes are activated from inactive (latent) zymogen forms.

The Astacin family members include meprins, BMP1, tolloid. Some of the members of the Astacin family of endopeptidases ... ... ... ...
 
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Entry last modified: March 2012