BAI-1

[brain-specific angiogenesis inhibitor-1] The approved gene symbol is ADGRB1 [Adhesion G-protein-coupled receptor B1].

The gene encoding BAI-1 is expressed specifically in the brain and has been identified as a gene the expression of which is inducible by p53 (Nishimori et al, 1997). The gene encodes a seven-span transmembrane protein of 1584 amino acids considered to be a member of the secretin receptor family. BAI-1 contains five thrombospondin type 1 repeats. The protein has been identified independently as GD-AIF [glioma-derived angiogenesis inhibitory factor]. Bioactive cleavage products of BAI-1 have been identified as Vasculostatin and Vasculostatin-40.

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Entry last modified: April 2016