BMPER

[BMP binding endothelial regulator; Bone morphogenetic protein-binding endothelial cell precursor-derived regulator] The protein is being referred to also as CRIM3 [cysteine-rich BMP regulator-3].

This protein is the mammalian homolog of Drosophila melanogaster Crossveinless-2, which is involved in wing morphogenesis (Conley et al, 2000). Serpe et al (2008) have shown that Crossveinless 2 is a secreted BMP binding protein. Its expression is controlled by BMP signaling. Crossveinless-2 enhances or inhibits BMP signaling. The protein promotes signaling in a biphasic manner by binding cell surfaces and heparan sulfate ... ... ... ...
 
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Entry last modified: November 2008