claw paw |
CLC2 |
BCL2-associated athanogene-5 |
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[cardiotrophin-like cytokine] The gene (approved gene symbol CLCF1 [cardiotrophin-like cytokine factor-1]) has been cloned and found to encode an open reading frame of 225 amino acids. The protein is most homologous to cardiotrophin-1 (Shi et al, 1999). CLC is identical with NNT-1/BSF-3. CLC has been shown to be one subunit of a heterodimeric cytokine. See: CLC/CLF.
The gene is expressed highly in spleen and peripheral leukocytes. The protein causes the activation of NF-kappa-B and SRE reporter constructs in cell lines TF-1, U937, and
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