Cop-1 |
COPA |
RRRRRRRR |
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Rat COP-1 has been identified by Zhang et al (1998) as a gene expressed by untransformed Rat-1 embryonic fibroblasts. Its expression is lost after cell transformation caused by a variety of mechanisms. Ectopic expression of the protein causes cell death in a transformation-specific manner.
COP-1 is a member of family of cysteine-rich growth regulators (CCN family). Sequence analysis shows that the protein is identical with CCN5 (which is identical with WISP-2).
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