CXCR3A |
CXCR4 |
Ferroportin-1 |
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[CXC-Chemokine receptor 3B] CXCR3B is an alternative splice form of CXCR3. Engagement of this receptor by IP-10, Mig, and I-TAC inhibits growth of endothelial cells. CXCR3B also acts as functional high-affinity receptor for PF4 (platelet factor-4), as shown by specific binding of PF4 to the human microvascular endothelial cell line HMEC-1 engineered to express CXCR3 or CXCR3B.
Overexpression of CXCR3B dramatically reduces DNA synthesis and upregulates cell death by apoptosis in HMEC-1 cells. Primary cultures of human microvascular endothelial cells
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