elastokines |
ELAVL1 |
Lymphocyte antigen 4 |
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[embryonic lethal abnormal visual system; embryonic lethal abnormal vision] This Drosophila protein, encoded by CG4262, is required for neuronal development and maintenance (Yao et al, 1993). Deficiency in ELAV causes abnormal neural development and leads to embryonic lethality in Drosophila melanogaster (Campos et al, 1985, 1987; Robinow et al, 1988). It is also required for maintenance of the nervous system in adult flies (Robinow and White, 1988; Yao et al, 1993).
Evolutionarily conserved mammalian homologs of this protein exist and have been described as Hu antigens. These constitute a family of RNA-binding proteins that bind to AU-rich elements in manty shortlived RNA
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