fluorescent granular perithelial cells |
flvi-2 |
Tu-AMP-2 |
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(5-Fluorouracil; abbr. 5-FU).
Fluorouracil is a substrate for thymidylate synthase, an enzyme which catalyses the conversion of deoxyuridine monophosphate (dUMP) to thymidine monophosphate (TMP) and thus plays a key role in the biosynthesis of pyrimidine bases. Thymidylate synthase converts Fluorouracil into 5-fluorodeoxyuridylate in vivo. Fluorouracil is a so-called suicide inhibitor of thymidylate synthase
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