GADS

[GRB2 related adaptor downstream of shc] This protein is identical with Mona, which is an adaptor molecule for the fms M-CSF receptor. It has been isolated independently as GRID [GRB2-related adaptor protein 2] and GRAP2 [GRB2-related adaptor protein 2].

Yoder et al (2001) have identified GADS as a protein adaptor involved in CD3 signaling. It is recruted to other adaptor proteins after activation of the T-cell receptor. Yoder et al (2001) have generated knock-out mice lacking expression of GADS. These animals are healthy but have fewer and severely defective thymocytes ... ... ... ...
 
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Entry last modified: June 2003