GICACRRRFCPNSERFSGYCRVNGARYVRCCSRR |
GICRCICGRGICRCICGR |
GLLSGILGAGKHIVCGLSGLC |
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approved gene symbol: MCAM [Melanoma cell adhesion molecule]. Gicerin is an integral membrane glycoprotein of about 82 kDa (584 amino acids) that belongs to the immunoglobulin superfamily and functions as a cell adhesion molecule. It binds neurite outgrowth factor (NOF), an extracellular matrix glycoprotein belonging to the laminin family, which promotes neurite extension from neuronal cells (Taira et al, 1994; Takaha et al, 1995).
1-gicerin and (90 kDa) s-gicerin (82 kDa) are two splice isoforms of Gicerin (Taira et al, 1995).
In the nomenclature of CD antigens this protein has been given the designation CD146.
For additional information on CD antigens
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