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Kappa-Interferon. IFN-kappa (207 amino acids, including a signal peptide of 27 amino acids) is a subclass of Type 1 interferon that displays approximately 30 % homology to other members of the interferon family (LaFleur et al, 2001). The protein binds strongly to heparin (Nardelli et al, 2002). Huang et al (2007) have reported that IFN-kappa signals through the canonical type 1 interferon receptor complex (consisting of the two subunits IFN-alphaR1 and IFN-alphaR2).

The gene encoding IFN-kappa is expressed in epidermal keratinocytes. Its expression is enhanced significantly upon viral infection, exposure to double-stranded RNA, or treatment with IFN-gamma or IFN-beta. IFN-kappa mRNA is expressed in resting dendritic cells and monocytes, and its expression is upregulated by IFN-gamma stimulation in monocytes.

Administration of recombinant IFN-kappa protects cells against viral infection in a species-specific manner. IFN-kappa utilizes the same receptor as IFN-alpha and IFN-beta.

IFN-kappa induces the release of several cytokines from monocytes and dendritic cells without the requirement of a costimulatory signal. IFN-kappa is particularly effective in inhibiting inducible IL12 release from monocytes. IFN-kappa does not induce the release of IFN-gamma by peripheral blood leukocytes.

Copyright 2012 by H IBELGAUFTS. All rights reserved.


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