IFN-kappa

[interferon-kappa] also: Kappa-Interferon; approved gene symbol: IFNK. IFN-kappa (207 amino acids, including a signal peptide of 27 amino acids) is a subclass of Type 1 interferon that displays approximately 30 % homology to other members of the interferon family (LaFleur et al, 2001). The protein binds strongly to heparin (Nardelli et al, 2002). Huang et al (2007) have reported that IFN-kappa signals through the canonical type 1 interferon receptor complex (consisting of the two subunits IFN-alphaR1 and IFN-alphaR2).

The gene encoding IFN-kappa is expressed in epidermal keratinocytes. Its expression is enhanced significantly upon viral infection, exposure to double-stranded RNA, or treatment with ... ... ... ...
 
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Entry last modified: August 2014