Cytokines & Cells Online Pathfinder Encyclopaedia
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Cytokines & Cells Online Pathfinder Encyclopaedia |
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This term has been used in several different ways.
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(-1-) cytotoxic killer T-cell activating factor
This biochemically uncharacterized factor is an acidic protein of 70-100 kDa produced by some macrophage-like cell lines and the human monocytic leukemia cell line THP-1. It activates human cytotoxic killer T-lymphocytes in vitro against autologous tumors.
LAST MODIFIED: January 2002
REFERENCES: Maeda N et al Augmentation of human cytotoxic T lymphocytes against autologous tumor by a factor released from human monocytic leukemia cell line. Japanese Journal of Cancer Research 80: 537-545 (1989)
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(-2-) keratinocyte-derived autocrine factor
The known 20 aminoterminal amino acids of KAF are completely identical with AR (amphiregulin) and the factor is called also, therefore, Keratinocyte-derived amphiregulin. Antibodies directed against KAF also recognise amphiregulin.
KAF is produced by keratinocytes and mammary epithelial cells. It stimulates the growth of human keratinocytes (see also: autocrine) and some murine cell lines. Its mitogenic activity is inhibited by heparin and dextran sulfate (see also: HBGF, heparin binding growth factors). Heparin sulfate also inhibits the competition of KAF for the EGF receptor.
ENTRY COMPLETED
REFERENCES: Cook PW et al A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. Molecular Cellular Biology 11: 2547-2557 (1991); Cook PW et al Inhibition of autonomous human keratinocyte proliferation and amphiregulin mitogenic activity by sulfated polysaccharides. In vitro Cellular and Developmental Biology 28A: 218-222 (1992)
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(-3-) kidney angiogenic factor
This factor was isolated initially from bovine kidney as a mitogenic for endothelial cells (see also: Angiogenesis). It is identical with bFGF.
See also: Angiogenesis Dictionary section of this encyclopedia for other entries directly bearing on factors and processes involved in the generation of new blood vessels.
ENTRY COMPLETED
REFERENCES: Baird A et al Isolation and partial characterization of an endothelial cell growth factor from bovine kidney: homology with basic fibroblast growth factor. Regulatory Peptides 12: 201-203 (1985)
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