Lubricating glycoprotein-1 |
LUCA-1 |
Scygonadin 1 |
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Lubricating glycoprotein-1 (LGP-1), renamed Lubricin, was prepared initially from bovine synovial fluid as a mucinous glycoprotein able to lubricate articular cartilage in a manner equivalent to that of whole synovial fluid (Swann et al, 1981). The protein is the product of the Proteoglycan-4 (PRG-4) gene.
Lubricin is secreted by synovial fibroblasts and articular chondrocytes (Jay et al, 2001). Lubricin is a fragment derived from exons 6 through 9 of MSF (megakaryocyte stimulating factor (Jay et al, 2000). Homology also exists between SZP (superficial zone protein,
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