maize basic peptide-1 |
major basic protein |
Ma-type bipolar cells |
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[molecule associated with Jak3 N-terminal] This protein has been identified in a screen for proteins interacting with the signal transducer JAK3. Interaction of MAJN and JAK3 does not depend on tyrosine phosphorylation of JAK3. Overexpression of MAJN can partially inhibit cell death by apoptosis induced by withdrawal of IL2 (Ji et al, 2000).
MAJN has been identified independently as TIAF-1 [TGF-beta-1 induced anti-apoptotic factor-1], MYSPDZ [myosin-containing PDZ domain] (with a role in hematopoiesis) and KIAA0216.
For other entries pertaining to cell death mechanisms see also the
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