Marchand cells |
Marek disease virus MEQ protein |
Colony inhibitory factor |
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[macrophage receptor with collagenous structure] MARCO (approved gene symbol) is a type II transmembrane protein of the class A scavenger receptor family (Kraal et al, 2000). An alternative designation is SCARA2 [scavenger receptor class A member 2].
MARCO has a short N-terminal cytoplasmic domain, a transmembrane domain, and a large extracellular part composed of a 75-residue long spacer domain, a 270-residue collagenous domain, and a 99-residue long scavenger receptor cysteine-rich (SRCR) domain.
MARCO binds heat-killed and living bacteria, having bacterial lipopolysaccharides as a ligand and thus serves as a pattern recognition receptor
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