Methuosis |
methyl 2,5-dihydroxycinnamate |
MjALF2 |
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abbr. Mth. This Drosophila melanogaster protein is a G-protein-coupled receptor encoded by gene CG6936.
Methuselah has been implicated in aging and extended life-span (Lin et al, 1998; Petrosyan et al, 2014) and stress resistance (Lin et al, 1998).
Song W et al (2002) have reported that Methuselah is required in the presynaptic motor neuron to acutely upregulate neurotransmitter exocytosis at larval Drosophila neuromuscular junctions. This function of Methuselah appears to be distinct from its effects on longevity
Shukla et al (2014) have reported that Methuselah plays a role in preventing dopaminergic neuron cell death as a consequence of exposure to Paraquat. Mutant flies
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