NSELINSLLSLPKNMNDAamide |
NSGMINSILGIPRVMTEAamide |
X-linked severe combined immunodeficiency-1 |
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[Nonspecific suppressor factor] Human NSF, designated hNSF, can be isolated from the ascitic fluid of a patient with systemic lupus erythematosus, the conditioned medium of ConA-activated T-cells, but not from CD8 depleted T-cells (Xavier et al, 1994).
NSF inhibits the proliferation and IgG production of mitogen-stimulated human peripheral blood mononuclear cells. It also strongly inhibits the proliferation and Ig secretion by highly purified B-cells induced by SAC plus IL2 and the proliferation of T-cells activated by Con A plus IL2 (Xavier et al, 1995). The factor is probably the counterpart of the murine
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