Cytokines & Cells Online Pathfinder Encyclopaedia
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Horst Ibelgaufts' COPE:
Cytokines & Cells Online Pathfinder Encyclopaedia |
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abbr. NMB. Neuromedin B has been identified originally in porcine spinal cord as a novel decapaptide that potently stimulates rat smooth muscle (Minamino et al, 1983). This amidated decapeptide is the mammalian homolog of the amphibian ranatensin (Krane et al, 1988), a peptide belonging to a large family of peptides related to Bombesin (see also: Mammalian Bombesin, Tachykinins). Hoggard et al (2007) have reported that neuromedin B is expressed in both human and rodent adipose tissue and appears to be regulated by changes in energy balance. It may form part of a new adipose tissue-hypothalamic axis regulating food intake.
Human neuromedin B is encoded within a precursor of 76 amino acids. The human gene is expressed widely in the brain and the gastrointestinal tract.
Neuromedin B shows activities like growth factors and cytokines although it is not classified as such due to its small size (see also: regulatory peptide factors). Siegfried et al (1999) have reported that the peptide acts as an autocrine growth factor for non-small cell lung carcinomas.
For other entries pertaining to low molecular weight substances that are not classified as cytokines or growth factors but that possess activities of cytokines see also: regulatory peptide factors.
LAST MODIFIED: August 2008
See REFERENCES for entry Neuromedin B
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