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PCF

This term has been used in several different ways.

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(-1-) peritoneal cytotoxic factor

A cytotoxic factor released by macrophages into the peritoneal fluid following treatment of tumor-bearing mice with the streptococcal preparation OK-432. The factor is most likely identical with TNF.

REFERENCES: Nagamuta M et al [Induction of a cytotoxic factor into the peritoneal fluid (PCF) by OK-432. II. Physicochemical and immunological characteristics of PCF] Gan To Kagaku Ryoho 13: 2358-2362 (1986); Watanabe N et al Therapeutic effect of endogenous tumor necrosis factor on ascites Meth A sarcoma. Journal of Immunopharmacology 8: 271-283 (1986); Yamamoto A et al Release of tumor necrosis factor (TNF) into mouse peritoneal fluids by OK-432, a streptococcal preparation. Immunopharmacology 11: 79-86 (1986)

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(-2-) plasmacytoma cytotoxic factor

This biochemically uncharacterized factor is secreted by P388D1 murine macrophage-like cells. PCF selectively kills certain tumor cell lines, including MOPC-315 plasmacytoma in vitro, by inducing cell death by apoptosis. This is accompanied by an increase of FAS antigen, FAS ligand, and Caspase-3 in PC-treated cells

LAST MODIFIED: July 2004

REFERENCES: Chu CY and Tseng J Induction of Fas and Fas-ligand expression in plasmacytoma cells by a cytotoxic factor secreted by murine macrophages. Journal of Biomedical Science 7(1): 58-63 (2000)

PCF

The following COPE entries contain this entry term or one of its hypertext synonyms:

adipocytes, astrocytes, B-cells, Beta-cells, cardiomyocytes, chief cells, cholangiocytes, chondrocytes, chromaffin cells, Clara cells, colonocytes, cumulus cells, Cytokine Inter-species Reactivities, dendritic cells, ECL cells, endometrial cells, endothelial cells, enterocytes, eosinophils, ependymal cells, erythrocytes, fibroblasts, Folliculo-stellate cells, G cells, goblet cells, granulosa cells, hepatic stellate cells, hepatocellular carcinoma, hepatocytes, Hofbauer cells, juxtaglomerular cells, keratinocytes, keratocytes, Kupffer cells, Langerhans cells, Leydig cells, Liver sinusoidal endothelial cells, macrophages, mast cells, megakaryocytes, melanocytes, melanoma cells, mesangial cells, mesothelial cells, microglial cells, monocytes, multiple myeloma cells, Müller cells, myofibroblasts, neurons, neutrophils, NK-cells, NKT-cells, oligodendrocytes, osteoblasts, osteoclasts, pancreatic acinar cells, Paneth cells, parietal cells, pericytes, Peritoneal cytotoxic factor, pinealocytes, pneumocytes, Purkinje cells, Reed-Sternberg cells, Retinal pigment epithelium cells, SaOS-2, Schwann cells, sebocytes, Sertoli cells, Sezary cells, smooth muscle cells, spermatocytes, synoviocytes, T-cells, tendon cells, Theca cells, thymic epithelial cells, thyrocytes, TNF-alpha, trabecular meshwork cells, trophoblasts, Uncharacterized factors.

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