PDCD9

[programmed cell death-9] PDCD9 is the mammalian counterpart of the Gallus gallus pro-apoptotic protein p52 (Carim et al, 1999). The protein sequences of chicken, mouse, and human PDCD9 are remarkably conserved. The human cDNA encodes a protein of 438 amino acids. PDCD9 mRNA is expressed ubiquitously in adult tissues.

p52 has been purified from chicken embryos and is expressed in a wide range of embryonic and adult tissues. Expression of p52 in mouse C3H10T1/2 fibroblasts causes cell death by apoptosis, upregulation of transcription factor c-Jun and activation of c-Jun N-terminal kinase 1. Expression of ... ... ... ...
 
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Entry last modified: January 2002