SCAN domain
[SCAN domains]
also: SCAN box. The SCAN domain is a highly conserved leucine-rich motif of 84 residues found at the N-terminal end of a subfamily of zinc finger transcription factors. It is named after the first letters of some previously discovered family members [SREZBP, Ctfin51, AW-1 (ZNF174), and Number 18 cDNA (Williams et al, 1995; Pengue et al, 1994).
The domain is not found outside the mammalian lineage (Edelstein and Collins, 2005). The SCAN domain has no proven transcriptional activation or repression activity and its sole function appears to be that of a protein-protein interaction domain
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