SLAM

[signaling lymphocyte activation molecule] This is the same as SLAMF1 [signaling lymphocyte activation molecule family member 1].

This protein of 70 kDa has been identified by Cocks et al (1995). It is involved in cell activation of T-cells. SLAM is expressed constitutively on peripheral blood memory T-cells expressing high levels of CD45RO, T-cell clones, immature thymocytes, and a subpopulation of B-cells. Its expression is induced rapidly rapidlky on naive T-cells after cell activation. Engagement of SLAM on CD4(+) T-cells enhances antigen-specific T-cell proliferation and ... ... ... ...
 
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