TMEM158 |
TMEM173 |
5S,12R,18R)-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid |
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[transmembrane protein 166] The approved gene symbol for this protein is FAM176A [family with sequence similarity 176 member A].
TMEM166 is a membrane protein found in lysosomes and endoplasmic reticulum. Overexpression of TMEM166 markedly inhibits colony formation in HeLa cells in a colony formation assay and causes autophagy or cell death by apoptosis. Suppression of TMEM166 expression inhibits starvation-induced autophagy in HeLa cells.
He et al (2009) have identified TMEM166 as one of several genes the overexpression of which induces high levels of autophagosome formation (see also: autophagy).
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