TOM |
Tomoregulin-1 |
RING finger protein 23 |
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abbr. TR. The gene is known as TMEFF2 [transmembrane protein with EGF-like and 2 follistatin-like domains 2] (a designation that in some publications is used also for tomoregulin-2) or hyperplastic polyposis gene 1 (HPP1), a gene commonly methylated and silenced in colorectal polyps and cancers (Young et al, 2001; Shibata et al, 2002; Sato et al, 2002; Geddert et al, 2004; Schulmann et al, 2005; Ebert et al, 2005; Brucher et al, 2006). The gene is also being referred to as TPEF [transmembrane protein containing epidermal growth factor and follistatin domain]. For a related gene see: Tomoregulin-1.
Tomoregulin (368 amino acids) contains two follistatin
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