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Embryonic stem cell growth factor
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abbr. UF. Uteroferrin is a purple-colored progesterone induced glycoprotein of 35 kDa containing two molecules of iron. It is the major secretory product of the porcine uterus under the influence of progesterone. The protein is secreted by glandular epithelium. As a transplacental iron-transport protein supplies iron to the developing fetuses during pregnancy.
Uteroferrin has been shown to be an intracellular tartrate-resistant acid phosphatase that shares many properties with the type 5 tartrate-resistant acid phosphatase in human placenta, the chondrocytes of osteoclastic bone tumors, and spleens of hairy cell leukemia. Uteroferrin also exists in a heterodimeric form associated with one of three uteroferrin-associated proteins that have high amino acid sequence homology with serine protease inhibitors.
Human and porcine uteroferrin have been shown to function as a hematopoietic growth factor that act on BFU-E, CFU-GM, and CFU-GEMM hematopoietic progenitors (see also: Hematopoietins). One of the functions of uteroferrin may be the initiation of Hematopoiesis and colonization of the hematopoietic organs during the first and second trimesters of gestation.
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ENTRY LAST MODIFIED: January 2002
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