XAF1

[X-linked inhibitor of apoptosis-associated factor-1; XIAP associated factor-1] XAF1 is the approved gene symbol. The protein is known also as BIRC4BP [BIRC4 binding protein], referring to BIRC4 = XIAP.

XAF1 is a protein that promotes cell death by apoptosis by interacting with XIAP and blocking the anti-apoptotic activity of XIAP, which is due to XIAP mediated inhibition of caspase-3 (Liston et al, 2001). Splice variants of XAF1 have been reported. Their ratio differs amongst cell lines but their functions remain to be elucidated (Yin et al, 2006).

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Entry last modified: August 2012