YVAD

The synthetic tetrapeptide YVAD (Tyr-Val-Ala-Asp) conjugated to p-nitroanilide (YVAD-pNA) is a colorimetric substrate for caspase-1 enzyme activity. YVAD-AFC (YVAD conjugated to 7-amino-4-trifluoromethyl coumarin) and YVAD-AMC (YVAD conjugated to Amino-4-methyl coumarin) are fluorogenic substrates for the caspase which is detectable following cleavage of the substituted coumarin moiety from the peptide.

The tetrapeptide coupled to fluoromethylketone (YVAD-fmk) is a synthetic inhibitor of caspases. The aldehyde derivative (YVAD-CHO) is another inhibitor.

The N-Acetyl-derivatives of these compounds (Ac-YVAD-AFC, ... ... ... ...
 
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Entry last modified: March 2003