hsp70

[heat shock protein 70] hsp70 is one of the heat shock proteins that mediate cellular protection in response to stress signals. For a bioactive cryptic peptide fragment see also: Hsp70(241-258). For a bacterial hsp70 see: Mycobacterium tuberculosis DnaK. See also: HSPA8 [heat shock 70 kDa protein 8; heat shock protein A8].

hsp70 has been shown to interfere directly with the process of cell death by apoptosis. hsp70 has been shown to prevent the activation of caspases. It binds directly to APAF-1, one of the components of the apoptosome and prevents the recruitment of caspases to this complex.

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Entry last modified: December 2014