Kininostatin |
Kinocidins |
transitional type 1 B-cells |
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The term kinin has been used as a collective term to designate polypeptides generated or released from stores in the blood or in tissues that are pharmacologically active on the smooth muscle and alter arterial tension. The term usually pertains to bioactive short peptides encoded by Kininogens. These peptides are short-lived mediators but they have been implicated in numerous physiological and pathophysiological processes (note that the general term kinin or leukokinin is being used also for a larger family of invertebrate peptides with myotropic and diuretic activity that are unrelated to kininogen parent proteins (for overview see: Torfs et al, 1999).
Kinin peptides are liberated from the precursor protein by proteolytic digestion, involving, for example, tissue and plasma
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