necrosome

this term - also necroptosome - coined in analogy with inflammasome, pyroptosome, ripoptosome, piddosome, refers to a distinct set of signaling proteins that include RIP1, RIP3, and caspase-8 (for structural considerations see also: Mompeán M et al, 2018). These biochemical complexes are thought to mediate a distinct form of regulated necrosis referred to as necroptosis (Wallach et al, 2011; Galluzzi et al, 2011; Dickens et al, 2012).

TNF-alpha stimulation induces the formation of a necrosome in which RIP3 ... ... ... ...
 
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Entry last modified: March 2018