tax-transcriptionally activated glycoprotein 1 ligand |
T-BAM |
SP-A1 |
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abbr. TIG2. The expression of this gene is upregulated by the treatment of skin raft cultures with the synthetic retinoid tazarotene. The TIG2 cDNA encodes a protein of 164 amino acids. TIG2 is not expressed in primary keratinocytes and fibroblasts. TIG2 is expressed and induced by tazarotene only when keratinocytes and fibroblasts form a tissue-like 3-dimensional structure. TIG2 is expressed at high levels in nonlesional psoriatic skin but at lower levels in psoriatic lesions (Nagpal et al, 1997). The TIG2 protein is identical with Chemerin, and the receptor has been identified as ChemR23.
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