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AMSH

[associated molecule with the SH3 domain of STAM] The approved gene symbol for ASMH is STAMBP [STAM binding protein]. In databanks the term Endosome-associated ubiquitin isopeptidase is used as a synonym.

This signaling protein has been shown to associate with other signal transducers, STAM and STAM-2. The AMSH protein also contains a putative bipartite nuclear localization signal and a homologous region of a jun activation domain-binding protein 1 (JAB1) subdomain (Tanaka et al, 1999). Ito et al (2001) have identified AMSH as a protein that binds directly to the signaling molecule SMAD6.

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