stalkokines |
STAM-1 |
Growth-promoting factors |
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[signal-transducing adaptor molecule] This protein of 70 kDa contains an SH3 homology domain and an immunoreceptor tyrosine-based activation motif (ITAM). The protein has been renamed STAM-1 [signal-transducing adaptor molecule-1] following the identification of the structurally and functionally similar protein, STAM-2.
STAM was identified originally as a protein associated directly with and phosphorylated by the signaling Janus kinases JAK3 and JAK2 upon stimulation of cells with IL2
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