APAEHRFSFGLamide |
APAF-1-ALT |
Down regulatory protein of interleukin-2 receptor |
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[Apoptosis protease activating factor-1; Apoptotic protease-activating factor 1; apoptotic peptidase activating factor 1] A human cytosolic protein of 130 kDa related to Caenorhabditis elegans CED4 (Zou et al, 1997). Both genes are considered homologous. The cDNA has been identified independently as KIAA0413.
APAF-1 protein contains three functional regions: an N-terminal CARD domain that can bind to the zymogen form of caspase-9, a CED4 like region enabling self-oligomerization, and a regulatory C-terminus with WD-40 repeats masking the CARD and CED4 region. During
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