CED4

[Cell death protein 4] CED4 is expressed primarily during embryogenesis of the nematode Caenorhabditis elegans. Mutations in the CED4 gene (549 amino acids) block almost all of the cell deaths by apoptosis that normally occur during development (Yuan and Horvitz, 1992). CED4 and human APAF-1 and Drosophila melanogaster HAC-1 are considered homologous.

The CED4 protein contains a sequence motif at the N-terminus, which resembles the mammalian death effector domain known to function as a protein interaction motif in mammalian such as FLICE, FADD, and ... ... ... ...
 
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Entry last modified: June 2003